Shiga Toxin Induces Lipid Compression: A Mechanism for Generating Membrane Curvature

Autor: Haifei Gao, Ludger Johannes, Jean-Claude Florent, Eva Y. Chi, Jaroslaw Majewski, Erik B. Watkins

Publikováno v: Nano letters. 19(10)

Biomembranes are hard to compress laterally, and membrane area compressibility has not been associated with biological processes. Using X-ray surface scattering, we observed that bacterial Shiga toxin compresses lipid packing in a gel phase monolayer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c259ae8c0e5fe5e12e2ab3273b52a771
https://pubmed.ncbi.nlm.nih.gov/31538793

Mechanism of Shiga Toxin Clustering on Membranes

Autor: Weria Pezeshkian, Senthil Arumugam, John Hjort Ipsen, Ludger Johannes, Ulrike Becken, Patricia Bassereau, Julian C. Shillcock, Haifei Gao, Jean-Claude Florent

Publikováno v: ACS Nano
Pezeshkian, W, Gao, H, Arumugam, S, Becken, U, Bassereau, P, Florent, J C, Ipsen, J H, Johannes, L & Shillcock, J C 2017, ' Mechanism of Shiga Toxin Clustering on Membranes ', ACS Nano, vol. 11, no. 1, pp. 314-324 . https://doi.org/10.1021/acsnano.6b05706

The bacterial Shiga toxin interacts with its cellular receptor, the glycosphingolipid globotriaosylceramide (Gb3 or CD77), as a first step to entering target cells. Previous studies have shown that toxin molecules cluster on the plasma membrane, desp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363a058165f2d71a05f93121d2375cd2
http://europepmc.org/articles/PMC5348102

Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes

Autor: Paul-Alain Jaffrès, Loïc Lemiègre, Virginie Malard, Cristine Gonçalves, Julie Barbeau, Thierry Benvegnu, Haifei Gao, Allan Quelen, Chantal Pichon, Patrick Midoux, Mathieu Berchel

Publikováno v: Carbohydrate Research
Carbohydrate Research, Elsevier, 2016, 435, pp.142--148. ⟨10.1016/j.carres.2016.10.003⟩
Carbohydrate Research, 2016, 435, pp.142--148. ⟨10.1016/j.carres.2016.10.003⟩

International audience; An archaeal diether lipid possessing a tri-antenna of α-D-mannopyranoside linked via an oligoethylene spacer to a (2S)-2-(phytanyloxy)-3-(hexadecyloxy)propanoic acid backbone (TriMan-Diether) was designed and synthesized. Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323ad6e37d8c5fda837d9b8f4353e32c
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01398046

The Discovery of Novel β-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies

Autor: Chao Ma, Guanyu Yang, Hongwei Jin, Haifei Gao, Fengrong Xu, Peng Liu, Yongjian Li, Yan Niu, Chao Wang, Ping Xu

Publikováno v: Chemical Biology & Drug Design. 79:972-980

This article describes the identification of two small molecular inhibitors for β-secretase by integrating virtual screening with fluorescence resonance energy transfer bioassay. A ligand-based pharmacophore model was developed, and the sequential v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41e2e5b2a6ab3c3857a6229ed497b99e
https://doi.org/10.1111/j.1747-0285.2012.01367.x

Carbohydrate conformation and lipid condensation in monolayers containing glycosphingolipid Gb3: influence of acyl chain structure

Autor: Ludger Johannes, Thomas Arnold, Jean-Claude Florent, Nathalie Chopin, Haifei Gao, Bernd Struth, Erik B. Watkins, Andrew J. C. Dennison

Publikováno v: Biophysical journal 107(5), 1146-1155 (2014). doi:10.1016/j.bpj.2014.07.023

Globotriaosylceramide (Gb3), a glycosphingolipid found in the plasma membrane of animal cells, is the endocytic receptor of the bacterial Shiga toxin. Using x-ray reflectivity (XR) and grazing incidence x-ray diffraction (GIXD), lipid monolayers cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37efc3da635af78e0e904ec5ad74254b
https://pubmed.ncbi.nlm.nih.gov/25185550