Dose finding, bioavailability, and PK-PD of oral triapine with concurrent chemoradiation for locally advanced cervical cancer and vaginal cancer (ETCTN 9892).

Autor: Taylor SE; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. taylorse2@upmc.edu.; Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. taylorse2@upmc.edu., Behr S; Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Cooper KL; Biostatistics Facility, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Mahdi H; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Cancer Immunology Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Fabian D; Markey Cancer Center, Lexington, KY, USA., Gallion H; Markey Cancer Center, Lexington, KY, USA., Ueland F; Markey Cancer Center, Lexington, KY, USA., Vargo J; Department of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Orr B; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Girda E; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA., Courtney-Brooks M; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Olawaiye AB; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Randall LM; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology and Massey Comprehensive Cancer Center, Virginia Commonwealth University Health, Richmond, VA, USA., Richardson DL; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Sullivan SA; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology and Massey Comprehensive Cancer Center, Virginia Commonwealth University Health, Richmond, VA, USA., Huang M; Division of Gynecologic Oncology, University of Virginia, Charlottesville, VA, USA., Christner SM; Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Beriwal S; Department of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Lin Y; Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Biostatistics Facility, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Chauhan A; Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA., Chu E; Montefiore Einstein Cancer Canter, Bronx, NY, USA., Kohn EC; Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, USA., Kunos C; Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA., Ivy SP; Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, USA., Beumer JH; Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. beumerj@gmail.com.; Department of Pharmaceutical Sciences, School of Pharmacy, Pittsburgh, PA, USA. beumerj@gmail.com.; Division of Hematology/Oncology, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. beumerj@gmail.com.

Publikováno v: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2024 Dec 14; Vol. 95 (1), pp. 4. Date of Electronic Publication: 2024 Dec 14.

Computational pathology identifies immune-mediated collagen disruption to predict clinical outcomes in gynecologic malignancies.

Autor: Aggarwal A; Georgia Tech, Georgia, GA, USA.; Emory University, Georgia, GA, USA., Khalighi S; Emory University, Georgia, GA, USA., Babu D; Case Western Reserve University, Ohio, OH, USA., Li H; Case Western Reserve University, Ohio, OH, USA., Azarianpour-Esfahani S; Case Western Reserve University, Ohio, OH, USA., Corredor G; Emory University, Georgia, GA, USA.; Louis Stokes Cleveland Veterans Administration Medical Center, Ohio, OH, USA., Fu P; Case Western Reserve University, Ohio, OH, USA., Mokhtari M; Isfahan University of Medical Sciences, Isfahan, Iran., Pathak T; Emory University, Georgia, GA, USA., Thayer E; Emory University School of Medicine, Georgia, GA, USA., Modesitt S; Emory University School of Medicine, Georgia, GA, USA., Mahdi H; University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Avril S; Case Western Reserve University, Ohio, OH, USA., Madabhushi A; Georgia Tech, Georgia, GA, USA. anantm@emory.edu.; Emory University, Georgia, GA, USA. anantm@emory.edu.; Atlanta Veterans Administration Medical Center, Georgia, GA, USA. anantm@emory.edu.

Publikováno v: Communications medicine [Commun Med (Lond)] 2024 Jan 03; Vol. 4 (1), pp. 2. Date of Electronic Publication: 2024 Jan 03.

The promise of combining CDK4/6 inhibition with hormonal therapy in the first-line treatment setting for metastatic or recurrent endometrial adenocarcinoma.

Autor: Ray-Coquard I; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire (GINECO), Centre Leon Bèrard, Lyon, France., Monk BJ; Honor Health Research Institute, University of Arizona, Creighton University, Phoenix, Arizona, USA., Lorusso D; Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Catholic University of Sacred Heart, Rome, Italy., Mahdi H; Department of Obstetrics and Gynecology, Women's Health Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA., Upadhyay V; EQRx Inc, Cambridge, Massachusetts, USA., Graul R; EQRx Inc, Cambridge, Massachusetts, USA., Husain A; EQRx Inc, Cambridge, Massachusetts, USA., Mirza MR; Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Slomovitz B; Gynecologic Oncology, Mount Sinai Medical Center, Miami, Florida, USA bslomovitz@gog.org.

Publikováno v: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [Int J Gynecol Cancer] 2023 Dec 04; Vol. 33 (12), pp. 1943-1949. Date of Electronic Publication: 2023 Dec 04.

Targeting CD47-SIRPa axis shows potent preclinical anti-tumor activity as monotherapy and synergizes with PARP inhibition.

Autor: Al-Sudani H; Internal Medicine Department, Einstein Medical Center Montgomery, Philadelphia, PA, USA., Ni Y; Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA., Jones P; Magee Women's Research Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Karakilic H; Magee Women's Research Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Cui L; Trillium Therapeutics Inc, 2488 Dunwin Dr., Mississauga, ON, L5L 1J9, Canada., Johnson LDS; Trillium Therapeutics Inc, 2488 Dunwin Dr., Mississauga, ON, L5L 1J9, Canada., Rose PG; Section of Gynecologic Oncology, Women's Health Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, USA., Olawaiye A; Magee Women's Research Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Magee Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA.; Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Edwards RP; Magee Women's Research Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Magee Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA.; Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Uger RA; Trillium Therapeutics Inc, 2488 Dunwin Dr., Mississauga, ON, L5L 1J9, Canada., Lin GHY; Trillium Therapeutics Inc, 2488 Dunwin Dr., Mississauga, ON, L5L 1J9, Canada., Mahdi H; Magee Women's Research Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA. mahdihs@upmc.edu.; Magee Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA. mahdihs@upmc.edu.; Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA. mahdihs@upmc.edu.

Publikováno v: NPJ precision oncology [NPJ Precis Oncol] 2023 Jul 19; Vol. 7 (1), pp. 69. Date of Electronic Publication: 2023 Jul 19.

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gynecologic cancer.

Autor: Disis ML; Cancer Vaccine Institute, University of Washington, Seattle, Washington, USA., Adams SF; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, USA., Bajpai J; Medical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India.; Homi Bhabha National Institute, Mumbai, Maharashtra, India., Butler MO; Department of Medical Oncology and Hematology, Princess Margaret Hospital Cancer Centre, Toronto, Ontario, Canada., Curiel T; Dartmouth-Hitchcock's Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire, USA., Dodt SA; A Cottage for Counseling, Palm City, Florida, USA., Doherty L; Program in Women's Oncology, Women and Infants Hospital of Rhode Island, Providence, Rhode Island, USA., Emens LA; Department of Medicine, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA., Friedman CF; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Department of Medicine, Weill Cornell Medical College, New York, New York, USA., Gatti-Mays M; Pelotonia Institute for Immuno-Oncology, Division of Medical Oncology, The Ohio State University, Columbus, Ohio, USA., Geller MA; Department of Obstetrics, Gynecology & Women's Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, Minnesota, USA., Jazaeri A; Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., John VS; Department of Medical Oncology & Hematology, Northwell Health Cancer Institute, Lake Success, New York, USA., Kurnit KC; University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, USA., Liao JB; University of Washington School of Medicine, Seattle, Washington, USA., Mahdi H; Department of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA., Mills A; Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA., Zsiros E; Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA., Odunsi K; The University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois, USA odunsia@bsd.uchicago.edu.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2023 Jun; Vol. 11 (6).