Ultrasmall TPGS-PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into Pseudomonas aeruginosa Biofilms in Lungs

Autor: Knud J. Jensen, Mikkel B. Thygesen, Claus Sternberg, Hanne Mørck Nielsen, Søren S.-R. Bohr, Kasper K. Sørensen, Tommy Nylander, Zheng Huang, Nikos S. Hatzakis, Haidar Jumaa, Feng Wan, Sylvia Natalie Kłodzińska

Publikováno v: Wan, F, Bohr, S S-R, Kłodzińska, S N, Jumaa, H, Huang, Z, Nylander, T, Thygesen, M B, Sørensen, K K, Jensen, K J, Sternberg, C, Hatzakis, N & Mørck Nielsen, H 2020, ' Ultrasmall TPGS-PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into Pseudomonas aeruginosa Biofilms in Lungs ', ACS Applied Materials and Interfaces, vol. 12, no. 1, pp. 380-389 . https://doi.org/10.1021/acsami.9b19644

Inhaled antibiotic treatment of cystic fibrosis-related bacterial biofilm infections is challenging due to the pathological environment of the lungs. Here, we present an "environment adaptive" nanoparticle composed of a solid poly lactic-co-glycolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39136087b21688538ca2913c27ca4dc4
https://orbit.dtu.dk/en/publications/43b7c99f-73d4-44e6-b9de-9d9f4afc1963

Utilizing nanoparticles for improving anti-biofilm effects of azithromycin: A head-to-head comparison of modified hyaluronic acid nanogels and coated poly (lactic-co-glycolic acid) nanoparticles

Autor: Haidar Jumaa, Thomas Rades, Hanne Mørck Nielsen, Feng Wan, Sylvia Natalie Kłodzińska, Claus Sternberg

Publikováno v: Journal of colloid and interface science. 555

Hypothesis The widespread resistance of bacteria to traditional antibiotic treatments has expedited the search for novel therapies against these pathogens. The hypothesis of this work is that two distinctively different polymeric delivery systems, sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52270d16eeaee9bc7032d7f85f1f0ed4
https://pubmed.ncbi.nlm.nih.gov/31404843