Zobrazeno 1 - 10
of 165
pro vyhledávání: '"HaiHua Liang"'
Autor:
Feifei Chen, Qingmin Zhao, Ziqiong Yang, Rongrong Chen, Huiwen Pan, Yanhui Wang, Huan Liu, Qiao Cao, Jianhua Gan, Xia Liu, Naixia Zhang, Cai-Guang Yang, Haihua Liang, Lefu Lan
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012425 (2024)
Pathogenic bacteria's metabolic adaptation for survival and proliferation within hosts is a crucial aspect of bacterial pathogenesis. Here, we demonstrate that citrate, the first intermediate of the tricarboxylic acid (TCA) cycle, plays a key role as
Externí odkaz:
https://doaj.org/article/16b9afae0c2d4701a460bcd0522b4aef
Autor:
Xueliang Zhan, Kuo Zhang, Chenchen Wang, Qiao Fan, Xiujia Tang, Xi Zhang, Ke Wang, Yang Fu, Haihua Liang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Cyclic dimeric guanosine monophosphate (c-di-GMP) serves as a bacterial second messenger that modulates various processes including biofilm formation, motility, and host-microbe symbiosis. Numerous studies have conducted comprehensive analys
Externí odkaz:
https://doaj.org/article/20dec57180944230978704fc94b00983
Autor:
Xueliang Zhan, Kuo Zhang, Chenchen Wang, Qiao Fan, Xiujia Tang, Xi Zhang, Ke Wang, Yang Fu, Haihua Liang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/300a87a8e7cf4a639076685bb478bd8d
Autor:
Feifei Chen, Hongxia Di, Yanhui Wang, Chao Peng, Rongrong Chen, Huiwen Pan, Cai-Guang Yang, Haihua Liang, Lefu Lan
Publikováno v:
Virulence, Vol 14, Iss 1 (2023)
ABSTRACTIn many Gram-positive bacteria, the transpeptidase enzyme sortase A (SrtA) anchors surface proteins to cell wall and plays a critical role in the bacterial pathogenesis. Here, we show that in Staphylococcus aureus, an important human pathogen
Externí odkaz:
https://doaj.org/article/4e9609ff32474408999f647ca6ed988a
Autor:
Yunfu Lu, Feifei Chen, Qingmin Zhao, Qiao Cao, Rongrong Chen, Huiwen Pan, Yanhui Wang, Haixin Huang, Ruimin Huang, Qian Liu, Min Li, Taeok Bae, Haihua Liang, Lefu Lan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
The two-component regulatory system VraRS regulates transcription of penicillin-binding protein 2 in response to cell wall antimicrobials. Here, Lu et al. show that an enzyme from the wall teichoic acid biosynthetic pathway of MRSA can also modulate
Externí odkaz:
https://doaj.org/article/2484c106ae744239a0436ab30d0817fb
Publikováno v:
Cancer Medicine, Vol 11, Iss 21, Pp 4053-4069 (2022)
Abstract Background Mutational signatures are somatic mutation patterns enriching operational mutational processes, which can provide abundant information about the mechanism of cancer. However, understanding of the pathogenic biological processes is
Externí odkaz:
https://doaj.org/article/4897b899e2994d00921699c1519a2af5
Autor:
Shugang Qin, Wen Xiao, Chuanmin Zhou, Qinqin Pu, Xin Deng, Lefu Lan, Haihua Liang, Xiangrong Song, Min Wu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-27 (2022)
Abstract Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive pulmonary disorder (COPD), cancer, and severe infection requiring
Externí odkaz:
https://doaj.org/article/4182bfefaa424d4ea830077145317bea
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT The type VI secretion system (T6SS) is capable of secreting a variety of metal-binding proteins involved in metal ion uptake, and it mediates an active metal ion transport system that contributes to competition between bacteria. Pseudomonas
Externí odkaz:
https://doaj.org/article/af5bda805bc04500ba3de865945fb78e
Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa
Autor:
Gukui Chen, Jiashen Zhou, Yili Zuo, Weiping Huo, Juan Peng, Meng Li, Yani Zhang, Tietao Wang, Lin Zhang, Liang Zhang, Haihua Liang
Publikováno v:
eLife, Vol 10 (2021)
Cyclic-di-guanosine monophosphate (c-di-GMP) is an important effector associated with acute-chronic infection transition in Pseudomonas aeruginosa. Previously, we reported a signaling network SiaABCD, which regulates biofilm formation by modulating c
Externí odkaz:
https://doaj.org/article/f32e19be3f794ab58be95c41b882741a
Publikováno v:
Bio-Protocol, Vol 11, Iss 16 (2021)
Characterization of biofilm formation and metabolic activities is critical to investigating biofilm interactions with environmental factors and illustrating biofilm regulatory mechanisms. An appropriate in vitro model that mimics biofilm in vivo habi
Externí odkaz:
https://doaj.org/article/c0496fd5f7214de797f0cd5679a943f7