Zobrazeno 1 - 10
of 133
pro vyhledávání: '"HaiHai Liang"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Hypertension is a disease associated with epigenetic aging. However, the pathogenic mechanism underlying this relationship remains unclear. We aimed to characterize the shared genetic architecture of hypertension and epigenetic aging, and id
Externí odkaz:
https://doaj.org/article/4c486fdbeb674321806a1fd1b315a4ad
Autor:
Wei Su, Yingying Guo, Qianqian Wang, Lu Ma, Qing Zhang, Yuhan Zhang, Yiding Geng, Tongzhu Jin, Jiayu Guo, Ruoxuan Yang, Zhihui Niu, Lingxue Ren, Yan Wang, Zhiwei Ning, Wenyue Li, Wenxin He, Jian Sun, Tianyu Li, Zhixin Li, Hongli Shan, Haihai Liang
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 7, Pp 1643-1654 (2024)
Abstract The senescence of alveolar type II (AT2) cells impedes self-repair of the lung epithelium and contributes to lung injury in the setting of idiopathic pulmonary fibrosis (IPF). Yes-associated protein 1 (YAP1) is essential for cell growth and
Externí odkaz:
https://doaj.org/article/7170954fd93944ebad50c0bb3fd57d64
Autor:
Zhenbo Yang, Yilin Xie, Mengyang Li, Wenxian Chen, Changsheng Zhong, Jin Ju, Qin Deng, Huifang Wang, Ting Cheng, Lei Zhang, Weijie Du, Haihai Liang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 172, Iss , Pp 116229- (2024)
Reperfusion stands as a pivotal intervention for ischemic heart disease. However, the restoration of blood flow to ischemic tissue always lead to further damage, which is known as myocardial ischemia/reperfusion injury (MIRI). Ramelteon is an orally
Externí odkaz:
https://doaj.org/article/af517331712d432399481326b7b05006
Autor:
Rui Yang, Liangliang Li, Yumeng Hou, Yingnan Li, Jing Zhang, Na Yang, Yuhan Zhang, Weihang Ji, Tong Yu, Lifang Lv, Haihai Liang, Xuelian Li, Tianyu Li, Hongli Shan
Publikováno v:
Cell Death and Disease, Vol 14, Iss 5, Pp 1-11 (2023)
Abstract Cardiac hypertrophy is a common structural remodeling in many cardiovascular diseases. Recently, long non-coding RNAs (LncRNAs) were found to be involved in the physiological and pathological processes of cardiac hypertrophy. In this study,
Externí odkaz:
https://doaj.org/article/c164eb44a5f74b08bc9b7af93717252f
Autor:
Qi Dong, Tong Yu, Bo Chen, Mingyue Liu, Xiang Sun, Huiying Cao, Kaidong Liu, Huanhuan Xu, Yuquan Wang, Shuping Zhuang, Zixin Jin, Haihai Liang, Yang Hui, Yunyan Gu
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Poly (ADP-ribose) polymerase inhibitors (PARPis) are approved for cancer therapy according to their synthetic lethal interactions, and clinical trials have been applied in non–small cell lung cancer. However, the therapeutic efficacy of PARPis in l
Externí odkaz:
https://doaj.org/article/5c8e0bea0f8346e0ab867c5047a1766b
Autor:
Tianyu Li, Zhihui Niu, Tong Yu, Jinrui Li, Xin Lu, Mengqin Huang, Qianqian Wang, Xiaojiang Yu, Jiayue Feng, Bingqian Xu, Danyang Bing, Xuelian Li, Lifang Lu, Haihai Liang, Rui Yang, Bin Wang, Hongli Shan
Publikováno v:
MedComm, Vol 4, Iss 5, Pp n/a-n/a (2023)
Abstract Myocardial fibrosis post myocardial infarction (MI) is characterized by abnormal extracellular matrix (ECM) deposition and cardiac dysfunction could finally develop into serious heart disease, like heart failure. Lots of regulating factors i
Externí odkaz:
https://doaj.org/article/a7aada44e5844566bd6c56d02b33eda8
Autor:
Tianyu Li, Xue Xiong, Yujing Wang, Yue Li, Yao Liu, Mingxiu Zhang, Chao Li, Tong Yu, Wei Cao, Shuangshuang Chen, Huizhen Zhang, Xiaona Wang, Lifang Lv, Yuhong Zhou, Haihai Liang, Xuelian Li, Hongli Shan
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107888- (2023)
Summary: This study found that the level of neuroepithelial cell-transforming gene 1 protein (NET1) was significantly increased in a mouse cardiac fibrosis model. Moreover, the expression level of NET1 was increased in cardiac fibrosis induced by TGF
Externí odkaz:
https://doaj.org/article/f288bb519999461d870559fb502d0734
Autor:
Tingting Chen, Jiayu Guo, Liqiang Ai, Yuquan Wang, Yan Wang, Bo Chen, Mingyue Liu, Shuping Zhuang, Kaidong Liu, Zhangxiang Zhao, Haihai Liang, Yunyan Gu
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 5751-5764 (2023)
The incidence of lung cancer (LC) in Idiopathic Pulmonary Fibrosis (IPF) patients is more than twice that in non-IPF. This study aims to investigate IPF-to-LC pathogenesis and to develop a predictor for detecting IPF predisposing patients to LC. We c
Externí odkaz:
https://doaj.org/article/6580b6f319314e7a84dc55f05551bc3d
LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation
Autor:
Jian Sun, Tongzhu Jin, Zhihui Niu, Jiayu Guo, Yingying Guo, Ruoxuan Yang, Qianqian Wang, Huiying Gao, Yuhan Zhang, Tianyu Li, Wenxin He, Zhixin Li, Wenchao Ma, Wei Su, Liangliang Li, Xingxing Fan, Hongli Shan, Haihai Liang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 9, Pp 3602-3617 (2022)
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with unknown etiology and limited therapeutic options. Activation of fibroblasts is a prominent feature of pulmonary fibrosis. Here we report that lncRNA DACH1 (dachshund homolog 1) is down
Externí odkaz:
https://doaj.org/article/63a39103f757419bb443df957ccc550d
Autor:
Tong Yu, Yanyan Liu, Junwen Xue, Xiang Sun, Di Zhu, Lu Ma, Yingying Guo, Tongzhu Jin, Huiying Cao, Yingzhun Chen, Tong Zhu, Xuelian Li, Haihai Liang, Zhimin Du, Hongli Shan
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-14 (2022)
Abstract Non-small cell lung cancer (NSCLC) is highly malignant and heterogeneous form of lung cancer and involves various oncogene alterations. Glycolysis, an important step in tumor metabolism, is closely related to cancer progression. In this stud
Externí odkaz:
https://doaj.org/article/963aa111c5f64dad9019ab959a315b41