Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Hai-Young Kim"'
Autor:
Mingyue Li, Victor A. Beaumont, Shahajahan Akbar, Hannah Duncan, Arch Creasy, Wenge Wang, Kelly Sackett, Lisa Marzilli, Jason C. Rouse, Hai-Young Kim
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTThe higher order structure (HOS) of monoclonal antibodies (mAbs) is an important quality attribute with strong contribution to clinically relevant biological functions and drug safety. Due to the multi-faceted nature of HOS, the synergy of mu
Externí odkaz:
https://doaj.org/article/c60148f3693e491c9f2b5b111def14a8
Autor:
Andrea Casasola-LaMacchia, Robert Joseph Seward, Sophie Tourdot, Matthew Willetts, Gary Kruppa, Michael J. Agostino, Gabrielle Bergeron, Nathalie Ahyi-Amendah, Andrew Ciarla, Zhaojiang Lu, Hai-Young Kim, Timothy P. Hickling, Hendrik Neubert
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
CD4+ T-cell activation through recognition of Human Leukocyte Antigen II (HLAII)-presented peptides is a key step in the development of unwanted immune response against biotherapeutics, such as the generation of anti-drug antibodies (ADA). Therefore,
Externí odkaz:
https://doaj.org/article/1c443f281a734bfbb34a8294b97006f5
Autor:
Jongwon Lim, Hai-Young Kim
Publikováno v:
ACS Omega, Vol 5, Iss 23, Pp 14173-14179 (2020)
Externí odkaz:
https://doaj.org/article/ad818575df9d43a1b4e170ff14bb33f6
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37270 (2012)
Conformational changes are essential for protein-protein and protein-ligand recognition. Here we probed changes in the structure of the protein ubiquitin at low temperatures in supercooled water using NMR spectroscopy. We demonstrate that ubiquitin i
Externí odkaz:
https://doaj.org/article/5a35701d93b249068b18300eed85be55
Autor:
Mihirbaran Mandal, Li Xiao, Weidong Pan, Giovanna Scapin, Guoqing Li, Haiqun Tang, Shu-Wei Yang, Jianping Pan, Yuriko Root, Reynalda Keh de Jesus, Christine Yang, Winnie Prosise, Priya Dayananth, Asra Mirza, Alex G. Therien, Katherine Young, Amy Flattery, Charles Garlisi, Rumin Zhang, Donald Chu, Payal Sheth, Inhou Chu, Jin Wu, Carrie Markgraf, Hai-Young Kim, Ronald Painter, Todd W. Mayhood, Edward DiNunzio, Daniel F. Wyss, Alexei V. Buevich, Thierry Fischmann, Alexander Pasternak, Shuzhi Dong, Jacqueline D. Hicks, Artjohn Villafania, Lianzhu Liang, Nicholas Murgolo, Todd Black, William K. Hagmann, Jim Tata, Emma R. Parmee, Ann E. Weber, Jing Su, Haifeng Tang
Publikováno v:
Journal of Medicinal Chemistry. 65:16234-16251
With the emergence and rapid spreading of NDM-1 and existence of clinically relevant VIM-1 and IMP-1, discovery of pan inhibitors targeting metallo-beta-lactamases (MBLs) became critical in our battle against bacterial infection. Concurrent with our
Autor:
Anandan Palani, Matthew Lloyd Childers, Qinglin Pu, Matthew J. Mitcheltree, Symon Gathiaka, Christian Fischer, Lisa Nogle, Rachel L. Palte, Jared N. Cumming, J. Richard Miller, Spencer McMinn, Hai-Young Kim, Hongjun Zhang, Charles A. Lesburg, Adam Beard, Donovon A. Adpressa, Josep Saurí, Derun Li, Theodore A. Martinot, Thomas W. Lyons, David L. Sloman, Jialiang Wang, Peter Spacciapoli, Min Lu, Abdelghani Achab
Publikováno v:
ACS Med Chem Lett
[Image: see text] Comprehensive synthetic strategies afforded a diverse set of structurally unique bicyclic proline-containing arginase inhibitors with a high degree of three-dimensionality. The analogs that favored the Cγ-exo conformation of the pr
Autor:
Shuhei Kawamura, Rachel L. Palte, Hai-Young Kim, Josep Saurí, Christopher Sondey, My S. Mansueto, Michael D. Altman, Michelle R. Machacek
Publikováno v:
Bioorganicmedicinal chemistry. 66
Synthesis of medium-sized rings is known to be challenging due to high transannular strain especially for 9- and 10-membered rings. Herein we report design and synthesis of unprecedented 9- and 10-membered purine 8,5'-cyclonucleosides as the first cy
Publikováno v:
Journal of Pharmaceutical Sciences. 109:3223-3230
Protein higher order structure (HOS) is an important product quality attribute that governs the structure-function characteristics, safety, and efficacy of therapeutic proteins. Infrared (IR) spectroscopy has long been recognized as a powerful biophy
Autor:
Hai-Young Kim, Jongwon Lim
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 23, Pp 14173-14179 (2020)
ACS Omega, Vol 5, Iss 23, Pp 14173-14179 (2020)
The metazoan second messenger 2'3'-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) is a cyclic dinucleotide (CDN) that induces secretion of type I interferons and activates the immune system and has thus attracted significant interest
Autor:
Matthew J. Mitcheltree, Theodore A. Martinot, Thomas W. Lyons, Spencer McMinn, Peter W. Fan, Hyelim Cho, Christian Fischer, Kalyan Chakravarthy, David L. Sloman, Padmanabhan Eangoor, Jared N. Cumming, Charles A. Lesburg, Mangeng Cheng, Adam Beard, Derun Li, Hongjun Zhang, Jennifer O'Neil, Abdelghani Achab, Rachel L. Palte, Anandan Palani, J. Richard Miller, Josep Saurí, Symon Gathiaka, Hai-Young Kim
Publikováno v:
ACS Med Chem Lett
[Image: see text] The action of arginase, a metalloenzyme responsible for the hydrolysis of arginine to urea and ornithine, is hypothesized to suppress immune-cell activity within the tumor microenvironment, and thus its inhibition may constitute a m