Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Hai-Yang Law"'
Autor:
Ning Yuan Lee, Melissa Hum, Guek Peng Tan, Ai Choo Seah, Pei-Yi Ong, Patricia T. Kin, Chia Wei Lim, Jens Samol, Ngiap Chuan Tan, Hai-Yang Law, Min-Han Tan, Soo-Chin Lee, Peter Ang, Ann S. G. Lee
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background There is an unmet need for precise biomarkers for early non-invasive breast cancer detection. Here, we aimed to identify blood-based DNA methylation biomarkers that are associated with breast cancer. Methods DNA methylation profil
Externí odkaz:
https://doaj.org/article/d172b376676d4fff8bb751ff838dda6c
Autor:
Ning Yuan Lee, Melissa Hum, Guek Peng Tan, Ai Choo Seah, Patricia T. Kin, Ngiap Chuan Tan, Hai-Yang Law, Ann S. G. Lee
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-10 (2023)
Abstract Background Blood-based DNA methylation has shown great promise as a biomarker in a wide variety of diseases. Studies of DNA methylation in blood often utilize samples which have been cryopreserved for years or even decades. Therefore, change
Externí odkaz:
https://doaj.org/article/e9954d81753d423bb5f23e820cd2fa2d
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180984 (2017)
Molecular diagnosis of Huntington disease (HD) is currently performed by fluorescent repeat-flanking or triplet-primed PCR (TP-PCR) with capillary electrophoresis (CE). However, CE requires multiple post-PCR steps and may result in high cost in high-
Externí odkaz:
https://doaj.org/article/153914eea7724dd8aa2e44114a9685dd
Autor:
Valeh Hadavi, Amir Hossein Taromchi, Mahdi Malekpour, Behjat Gholami, Hai-Yang Law, Navid Almadani, Fariba Afroozan, Farhad Sahebjam, Parisa Pajouh, Roxana Kariminejad, Mohammad Hassan Kariminejad, Azita Azarkeivan, Maryam Jafroodi, Ahmad Tamaddoni, Helene Puehringer, Christian Oberkanins, Hossein Najmabadi
Publikováno v:
Haematologica, Vol 92, Iss 7 (2007)
α thalassemia (α-thal) is one of the most common hemoglobin (Hb) disorders in the world.1 α-globin genes are located on chromosome 16. The majority of α-thal mutations are deletions but point mutations are found as well.2 Since the Iranian popula
Externí odkaz:
https://doaj.org/article/64ed1525950d4e388d0afc15137a83a6
Autor:
Ann Siew Gek Lee, Peter Ang, Yoon Sim Yap, Min-Han Tan, Chui Sheun Yoon, Hai Yang Law, Edward Sern Yuen Wong, Geok Ling Koh, Sau Yeen Loke, Prabhakaran Munusamy, Claire Hian Tzer Chan
Supplementary data contains list of genes and SNP details
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c469b70c2af930856de0a2519b6027
https://doi.org/10.1158/0008-5472.22414409.v1
https://doi.org/10.1158/0008-5472.22414409.v1
Autor:
Ann Siew Gek Lee, Peter Ang, Yoon Sim Yap, Min-Han Tan, Chui Sheun Yoon, Hai Yang Law, Edward Sern Yuen Wong, Geok Ling Koh, Sau Yeen Loke, Prabhakaran Munusamy, Claire Hian Tzer Chan
It has been estimated that >1,000 genetic loci have yet to be identified for breast cancer risk. Here we report the first study utilizing targeted next-generation sequencing to identify single-nucleotide polymorphisms (SNP) associated with breast can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::340547b99988bf8e5dda0b302da2abd2
https://doi.org/10.1158/0008-5472.c.6508967.v1
https://doi.org/10.1158/0008-5472.c.6508967.v1
Publikováno v:
Clinical Chemistry. 68:794-802
Background The autosomal dominantly inherited and genetically heterogeneous spinocerebellar ataxias (SCAs) exhibit highly similar clinical presentations. Many are caused by repeat expansions, of which at least 8 involve CAG repeats. Repeat expansion
Publikováno v:
The Journal of Molecular Diagnostics. 24:241-252
Methylated FMR1 full-mutation expansions cause fragile X syndrome. FMR1 premutation carriers are susceptible to other late-onset conditions, and women with premutation are at risk of transmitting a fully expanded FMR1 allele to offspring. Identificat
Autor:
Nikki Fong, Jiin Ying Lim, Breana Cham, Sylvia Kam, Chew Yin Goh, Heming Wei, Yuen Ming Tan, Hai Yang Law, Weng Khong Lim, Ee Shien Tan, Ene Choo Tan, Saumya Shekhar Jamuar
Publikováno v:
Annals of the Academy of Medicine, Singapore. 51(12)
Autor:
Furene S. Wang, Caroline G.L. Lee, Samuel S. Chong, Yanghong Gu, Jozef Gecz, Hai-Yang Law, David L. Nelson, Timing Liu, Marie Shaw, Felicia S.H. Cheah, Stacey K.H. Tay
Publikováno v:
The Journal of Molecular Diagnostics. 23:941-951
Moderate to hyper-expansion of trinucleotide repeats at the FRAXA and FRAXE fragile sites, with or without concurrent hypermethylation, has been associated with intellectual disability and other conditions. Unlike molecular diagnosis of FMR1 CGG repe