Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Hai-Yan Zhou"'
Autor:
Lin-Yun Chen, Li-Wen Wang, Jie Wen, Jing-Dong Cao, Rui Zhou, Jin-Lin Yang, Ye Xiao, Tian Su, Yan Huang, Qi Guo, Hai-Yan Zhou, Xiang-Hang Luo, Xu Feng
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102053- (2024)
Objective: Activating brown adipose tissue (BAT) thermogenesis is a promising approach to combat obesity and metabolic disorders. The post-transcriptional regulation of BAT thermogenesis mediated by RNA-binding proteins (RBPs) is still not fully unde
Externí odkaz:
https://doaj.org/article/f5bc6524cc5543cb81d3702b2e6fe23b
Autor:
Lin‐Lin Song, Hai‐Yan Zhou, Pan‐Pan Ye, Qian Li, Ke‐Guang Chen, Ye‐Hui Zhang, Fu‐Rong Zhao, Jin‐Yi Shi, Yuan Luo, Min Zhu, Jian‐Jun Zhang, Xin‐Mei Yang, Wei Zhao
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 12, Pp 2604-2613 (2023)
Abstract New therapeutic targets and drugs are urgently needed to halt the fibrosing process in idiopathic pulmonary fibrosis (IPF). SHR‐1906 is a novel fully humanized monoclonal antibody against the connective tissue growth factor, which plays an
Externí odkaz:
https://doaj.org/article/1b7ece73a7064c25973c015cf3780020
Autor:
Ke-Guang Chen, Ye-Hui Zhang, Pan-Pan Ye, Xue-Hu Gao, Lin-Lin Song, Hai-Yan Zhou, Qian Li, Fu-Rong Zhao, Jin-Yi Shi, Xin-Mei Yang, Kai Shen, Sheng Feng, Wei Zhao
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Objectives: INS068 is a novel, soluble, and long-acting insulin analog. In this study, we evaluated the pharmacokinetics and relative bioavailability of two formulations of INS068 in healthy Chinese subjects: a reference formulation packaged in vials
Externí odkaz:
https://doaj.org/article/f45dc0a27fd447838e79e84cb91c38fc
Publikováno v:
Pediatrics and Neonatology, Vol 64, Iss 6, Pp 692- (2023)
Externí odkaz:
https://doaj.org/article/839dbd949eb040b4b0def5d8d86f97a1
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Hereditary spastic paraplegia (HSP) is a group of neurodegenerative diseases with genetic and clinical heterogeneity characterized by spasticity and weakness of the lower limbs. It includes four genetic inheritance forms: autosomal dominant inheritan
Externí odkaz:
https://doaj.org/article/337daccfdf8c41e5a11655221a12a1ab
Autor:
Cheng-cheng Yao, Rui-ming Sun, Yi Yang, Hai-yan Zhou, Zhou-wenli Meng, Rui Chi, Li-liang Xia, Ping Ji, Ying-ying Chen, Guo-qing Zhang, Hai-peng Sun, Shun Lu, Chen Yang, Ying Wang
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112186- (2023)
Summary: Branched-chain amino acids (BCAAs) provide nutrient signals for cell survival and growth. How BCAAs affect CD8+ T cell functions remains unexplored. Herein, we report that accumulation of BCAAs in CD8+ T cells due to the impairment of BCAA d
Externí odkaz:
https://doaj.org/article/9a67120eec8440ea890f0817fd804bcf
Autor:
Jing Li, Jie Li, Pei Huang, Li-Na Huang, Qing-Guo Ding, Linlin Zhan, Mengting Li, Jiaxi Zhang, Hongqiang Zhang, Lulu Cheng, Huayun Li, Dong-Qiang Liu, Hai-Yan Zhou, Xi-Ze Jia
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
BackgroundMyotonic dystrophy type 1 (DM1) is the most common and dominant inherited neuromuscular dystrophy disease in adults, involving multiple organs, including the brain. Although structural measurements showed that DM1 is predominantly associate
Externí odkaz:
https://doaj.org/article/bb03918864ae4cc9865d29058b7ce737
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Non-alcoholic fatty liver disease (NAFLD), hallmarked by liver steatosis, is becoming a global concern, but effective and safe drugs for NAFLD are still lacking at present. Parathyroid hormone (PTH), the only FDA-approved anabolic treatment for osteo
Externí odkaz:
https://doaj.org/article/32c87eaad2b14e00ad9edcb2f4f117f4
Autor:
Shi-Shuang Cui, Rao Fu, Juan-Juan Du, Yi-Qi Lin, Pei Huang, Chao Gao, Hai-Yan Zhou, Sheng-Di Chen
Publikováno v:
BMC Neuroscience, Vol 22, Iss 1, Pp 1-7 (2021)
Abstract Background Differences of genotypes between male and female have been studied in Parkinson’s disease (PD), but limited research has focused on the comparison between sexes with LRRK2 G2385 variant. Objective The aim of this study was to ex
Externí odkaz:
https://doaj.org/article/0c61dcf27df545b69171a798aeb6f79b
Publikováno v:
International Journal of Ophthalmology, Vol 14, Iss 2, Pp 240-244 (2021)
AIM: To investigate the significance of ultrasound elastography for evaluating stiffness of the human lens nucleus in volunteers with different ages. METHODS: A total of 90 volunteers (lens transparency, uncorrected visual acuity ≥0.5, intraocular
Externí odkaz:
https://doaj.org/article/fd6cfba8aade4acfbaa10880a70f860d