Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Hai-Xue Pan"'
Autor:
Wenli Guo, Zhihong Xiao, Tingting Huang, Kai Zhang, Hai-Xue Pan, Gong-Li Tang, Zixin Deng, Rubing Liang, Shuangjun Lin
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-14 (2023)
Abstract Background Streptomyces are well known for their potential to produce various pharmaceutically active compounds, the commercial development of which is often limited by the low productivity and purity of the desired compounds expressed by na
Externí odkaz:
https://doaj.org/article/3401ff666a1b4f9a8992ee0bdf1f3874
Publikováno v:
Antibiotics, Vol 12, Iss 1, p 35 (2022)
Self-resistance determinants are essential for the biosynthesis of bioactive natural products and are closely related to drug resistance in clinical settings. The study of self-resistance mechanisms has long moved forward on the discovery of new resi
Externí odkaz:
https://doaj.org/article/a24d6fd5a8644e208817ed7a6f6a9633
Publikováno v:
F1000Research, Vol 6 (2017)
Bacterial aromatic polyketides, exemplified by anthracyclines, angucyclines, tetracyclines, and pentangular polyphenols, are a large family of natural products with diverse structures and biological activities and are usually biosynthesized by type I
Externí odkaz:
https://doaj.org/article/d2bb60671419458cbfe18df144f821f2
Autor:
Yu Hu, Qiang Zhou, Hai-Xue Pan, Zhuan Zhang, Gong-Li Tang, Yulia Ilina, Yasuhiro Igarashi, Mikko Metsä-Ketelä
Publikováno v:
Chinese Journal of Chemistry. 39:3329-3333
Publikováno v:
Chinese Journal of Chemistry. 38:1607-1611
Autor:
Biao Yu, Wen-He Zhang, Gong-Li Tang, Juan Zhao, Wen-Jia Kang, Fei Wang, Shengyang Wang, Hai-Xue Pan
Publikováno v:
Journal of the American Chemical Society. 142:5996-6000
Miharamycins are peptidyl nucleoside antibiotics with a unique branched C9 pyranosyl amino acid core and a rare 2-aminopurine moiety. Inactivation of 19 genes in the biosynthetic gene cluster and identification of several unexpected intermediates sug
Publikováno v:
Organic letters. 23(22)
The biochemical elucidation of the early biosynthetic pathways of miharamycins and amipurimycin revealed the roles of several enzymes, which include GMP hydrolase, represented by MihD/ApmD, and hypothetical proteins, MihI/ApmI, unexpectedly exhibitin
Autor:
Yachen Zhao, Wen-Jia Kang, Jian-Song Sun, Fei Wang, Gong-Li Tang, Shengyang Wang, Qingju Zhang, Biao Yu, Hai-Xue Pan
Publikováno v:
Angewandte Chemie International Edition. 58:10558-10562
The structural puzzle of amipurimycin, a peptidyl nucleoside antibiotic, is solved by total synthesis and X-ray diffraction analysis, with the originally proposed configurations at C3' and C8' inverted and those at C6', C2'', and C3'' corrected. A si
Bacterial type II polyketides, an important class of natural products biosynthesized by type II polyketide synthases, are rich in chemical scaffolds and biological activities. In the past three decades, the relative biosynthesis has resulted in signi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::173f64b61bac28cd298b7bb39b22d7a6
https://doi.org/10.1016/b978-0-12-409547-2.14626-8
https://doi.org/10.1016/b978-0-12-409547-2.14626-8
Publikováno v:
ChemBioChem. 19:2002-2022
Oxygen-containing heterocycles are widely encountered in natural products that display diverse pharmacological properties and have potential benefits to human health. The formation of O-heterocycles catalyzed by different types of enzymes in the bios