Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Hai-Ning Chen"'
Autor:
Tao Zhou, Huayun Yan, Yiqi Deng, Yunfeng Zhu, Xuyang Xia, Wanchun Wu, Wei‐Han Zhang, Hai‐Ning Chen, Jian‐Kun Hu, Zong‐Guang Zhou, Yang Shu, Yuan Li, Heng Xu
Publikováno v:
Interdisciplinary Medicine, Vol 2, Iss 4, Pp n/a-n/a (2024)
Abstract Long non‐coding RNAs (lncRNAs) can crucially regulate activation and transformation of cancer‐associated fibroblasts (CAFs) but have not been systematically investigated at single cell resolution. Here, by utilizing integrated single‐c
Externí odkaz:
https://doaj.org/article/4759bc0b0d53405685bf084193915cdc
Autor:
Kai He, Zhihan Wang, Maochao Luo, Bowen Li, Ning Ding, Lei Li, Bo He, Han Wang, Jiangjun Cao, Canhua Huang, Jun Yang, Hai-Ning Chen
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-23 (2023)
Abstract Distant metastasis remains a leading cause of mortality among patients with colorectal cancer (CRC). Organotropism, referring to the propensity of metastasis to target specific organs, is a well-documented phenomenon in CRC, with the liver,
Externí odkaz:
https://doaj.org/article/372c395c8634439fbd05f463d195fc98
Autor:
Kui Wang, Li Luo, Shuyue Fu, Mao Wang, Zihao Wang, Lixia Dong, Xingyun Wu, Lunzhi Dai, Yong Peng, Guobo Shen, Hai-Ning Chen, Edouard Collins Nice, Xiawei Wei, Canhua Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
The role of protein arginine methylation in serine metabolism of cancer cells in hepatocellular carcinoma (HCC) remains to be explored. Here, the authors show that phosphoglycerate dehydrogenase (PHGDH) is activated by PRMT1-mediated R236 methylation
Externí odkaz:
https://doaj.org/article/a8cf977e10a64602a434646123cf3d01
Autor:
Jingwen Jiang, Hai-Ning Chen, Ping Jin, Li Zhou, Liyuan Peng, Zhao Huang, Siyuan Qin, Bowen Li, Hui Ming, Maochao Luo, Na Xie, Wei Gao, Edouard C. Nice, Qiang Yu, Canhua Huang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract The single-nucleotide polymorphism (SNP) of p53, in particular the codon 72 variants, has recently been implicated as a critical regulator in tumor progression. However, the underlying mechanism remains elusive. Here we found that cancer cel
Externí odkaz:
https://doaj.org/article/a063a38a90044b598f89e07c240a37cd
Autor:
Ping Jin, Jingwen Jiang, Li Zhou, Zhao Huang, Siyuan Qin, Hai‐Ning Chen, Liyuan Peng, Zhe Zhang, Bowen Li, Maochao Luo, Tingting Zhang, Hui Ming, Ning Ding, Lei Li, Na Xie, Wei Gao, Wei Zhang, Edouard C Nice, Yuquan Wei, Canhua Huang
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 12, Pp 1-19 (2022)
Abstract Metformin, a well‐known antidiabetic drug, has been repurposed for cancer treatment; however, recently observed drug resistance and tumor metastasis have questioned its further application. Here, we found that long‐term metformin exposur
Externí odkaz:
https://doaj.org/article/21de7353346a45f899760eb85b44cfa8
Autor:
Han Luo, Xuyang Xia, Li-Bin Huang, Hyunsu An, Minyuan Cao, Gyeong Dae Kim, Hai-Ning Chen, Wei-Han Zhang, Yang Shu, Xiangyu Kong, Zhixiang Ren, Pei-Heng Li, Yang Liu, Huairong Tang, Ronghao Sun, Chao Li, Bing Bai, Weiguo Jia, Yi Liu, Wei Zhang, Li Yang, Yong Peng, Lunzhi Dai, Hongbo Hu, Yong Jiang, Yiguo Hu, Jingqiang Zhu, Hong Jiang, Zhihui Li, Carlos Caulin, Jihwan Park, Heng Xu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Cancer-associated fibroblasts (CAFs) are a predominant and critical component of the tumour microenvironment. Here, the authors integrate and analyse single-cell RNA-seq data of CAFs across 10 common solid cancer types, identifying their plasticity a
Externí odkaz:
https://doaj.org/article/67012cdd629648449d41549883cb9581
Autor:
Li Zhou, Jingwen Jiang, Zhao Huang, Ping Jin, Liyuan Peng, Maochao Luo, Zhe Zhang, Yan Chen, Na Xie, Wei Gao, Edouard C. Nice, Jing-Quan Li, Hai-Ning Chen, Canhua Huang
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-22 (2022)
Abstract Background Hypoxia, a typical hallmark of solid tumors, exhibits an essential role in the progression of colorectal cancer (CRC), in which the dysregulation of long non-coding RNAs (lncRNAs) is frequently observed. However, the underlying me
Externí odkaz:
https://doaj.org/article/44281bdaed5b4e568a7195b302e3f17b
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Metastasis is considered as the major cause of cancer death. Cancer cells can be released from primary tumors into the circulation and then colonize in distant organs. How cancer cells acquire the ability to colonize in distant organs has always been
Externí odkaz:
https://doaj.org/article/7cd198a87f4b4361a4f8b4be8a1d8dde
Autor:
Zhe Zhang, Siyuan Qin, Yan Chen, Li Zhou, Mei Yang, Yongquan Tang, Jing Zuo, Jian Zhang, Atsushi Mizokami, Edouard C Nice, Hai‐Ning Chen, Canhua Huang, Xiawei Wei
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 2, Pp 1-20 (2022)
Abstract Entering a drug‐tolerant persister (DTP) state of cancer cells is a transient self‐adaptive mechanism by which a residual cell subpopulation accelerates tumor progression. Here, we identified the acquisition of a DTP phenotype in multidr
Externí odkaz:
https://doaj.org/article/fba468bc75374ae3a4016b9dc92a4961
Autor:
Maochao Luo, Zhao Huang, Xingyue Yang, Yan Chen, Jingwen Jiang, Lu Zhang, Li Zhou, Siyuan Qin, Ping Jin, Shuyue Fu, Liyuan Peng, Bowen Li, Yongting Fang, Wenchen Pu, Yanqiu Gong, Yu Liu, Zhixiang Ren, Qiu-Luo Liu, Cun Wang, Fangqiong Xiao, Du He, Hongying Zhang, Changlong Li, Heng Xu, Lunzhi Dai, Yong Peng, Zong-Gung Zhou, Canhua Huang, Hai-Ning Chen
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 4, Pp 1223-1242 (2022)
Background & Aims: Latent metastasis of colorectal cancer (CRC) frequently develops months or years after primary surgery, followed by adjuvant therapies, and may progress rapidly even with targeted therapy administered, but the underlying mechanism
Externí odkaz:
https://doaj.org/article/a1daa589f2864ead9925abd441059ce7