Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Hai-Kun Liu"'
Autor:
Changwen Wang, Meng Sun, Chunxuan Shao, Lisa Schlicker, Yue Zhuo, Yassin Harim, Tianping Peng, Weili Tian, Nadja Stöffler, Martin Schneider, Dominic Helm, Youjun Chu, Beibei Fu, Xiaoliang Jin, Jan-Philipp Mallm, Moritz Mall, Yonghe Wu, Almut Schulze, Hai-Kun Liu
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-21 (2024)
Abstract Recent advances in the genomics of glioblastoma (GBM) led to the introduction of molecular neuropathology but failed to translate into treatment improvement. This is largely attributed to the genetic and phenotypic heterogeneity of GBM, whic
Externí odkaz:
https://doaj.org/article/d63afc60087d40eba8fc806d9ff1af6b
Autor:
Naveen C. Reddy, Shahriyar P. Majidi, Lingchun Kong, Mati Nemera, Cole J. Ferguson, Michael Moore, Tassia M. Goncalves, Hai-Kun Liu, James A. J. Fitzpatrick, Guoyan Zhao, Tomoko Yamada, Azad Bonni, Harrison W. Gabel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
CHARGE syndrome that affects cerebellar development can be caused by haploinsufficiency of the chromatin remodeling enzyme CHD7; however the precise role of CHD7 remains unknown. Here the authors show CHD7 promotes chromatin accessibility and enhance
Externí odkaz:
https://doaj.org/article/6b65df7f5b89436183b44caa5fad1079
Autor:
Kristian W. Pajtler, Yiju Wei, Konstantin Okonechnikov, Patricia B. G. Silva, Mikaella Vouri, Lei Zhang, Sebastian Brabetz, Laura Sieber, Melissa Gulley, Monika Mauermann, Tatjana Wedig, Norman Mack, Yuka Imamura Kawasawa, Tanvi Sharma, Marc Zuckermann, Felipe Andreiuolo, Eric Holland, Kendra Maass, Huiqin Körkel-Qu, Hai-Kun Liu, Felix Sahm, David Capper, Jens Bunt, Linda J. Richards, David T. W. Jones, Andrey Korshunov, Lukas Chavez, Peter Lichter, Mikio Hoshino, Stefan M. Pfister, Marcel Kool, Wei Li, Daisuke Kawauchi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The molecular mechanisms driving proliferation in the pediatric brain cancer epdendymoma are poorly understood. Here the authors show that a YAP1- MAMLD1 fusion drives tumor formation in mice and show that the fusion protein can collaborate with the
Externí odkaz:
https://doaj.org/article/adf1b461d84d45cc809ee416ce32b241
Autor:
Weijun Feng, Daisuke Kawauchi, Huiqin Körkel-Qu, Huan Deng, Elisabeth Serger, Laura Sieber, Jenna Ariel Lieberman, Silvia Jimeno-González, Sander Lambo, Bola S. Hanna, Yassin Harim, Malin Jansen, Anna Neuerburg, Olga Friesen, Marc Zuckermann, Vijayanad Rajendran, Jan Gronych, Olivier Ayrault, Andrey Korshunov, David T. W. Jones, Marcel Kool, Paul A. Northcott, Peter Lichter, Felipe Cortés-Ledesma, Stefan M. Pfister, Hai-Kun Liu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Mutations in the chromatin modifier Chd7 have been associated with CHARGE syndrome and other developmental disorders. Here the authors show that Chd7 is required for the activation of genes essential for cerebellar granule cell differentiation, and t
Externí odkaz:
https://doaj.org/article/a402443280f6419d867e3b5b78b484b1
Autor:
Barbara Costa, Michael N. C. Fletcher, Pavle Boskovic, Ekaterina L. Ivanova, Tanja Eisemann, Sabrina Lohr, Lukas Bunse, Martin Löwer, Stefanie Burchard, Andrey Korshunov, Nadia Coltella, Melania Cusimano, Luigi Naldini, Hai-Kun Liu, Michael Platten, Bernhard Radlwimmer, Peter Angel, Heike Peterziel
Publikováno v:
Cancers, Vol 13, Iss 2, p 230 (2021)
Glioblastomas (GBM) are the most aggressive tumors affecting the central nervous system in adults, causing death within, on average, 15 months after diagnosis. Immunocompetent in-vivo models that closely mirror human GBM are urgently needed for decip
Externí odkaz:
https://doaj.org/article/b57bd8c18c9341fb80e356429b46f2b5
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
CHD7 (Chromo-Helicase-DNA binding protein 7) protein is an ATP-dependent chromatin remodeler. Heterozygous mutation of the CHD7 gene causes a severe congenital disease known as CHARGE syndrome. Most CHARGE syndrome patients have brain structural anom
Externí odkaz:
https://doaj.org/article/5069763311a94f03be77c8ab5fcfa54a
Autor:
Hai-Kun Liu
Publikováno v:
Cell research. 32(9)
Autor:
Hui Yu, Xin-Yu Jiang, Jin Zhao, Hao Qi, Yu Zhang, Xiao-Fei Liao, Hai-Kun Liu, Fu-Bing Mao, Hai Jin
Publikováno v:
Journal of Computer Science and Technology. 37:797-813
Autor:
Changwen Wang, Meng Sun, Chunxuan Shao, Lisa Schlicker, Yue Zhuo, Yassin Harim, Tianping Peng, Weili Tian, Nadja Stöffler, Martin Schneider, Dominic Helm, Jan-Philipp Mallm, Yonghe Wu, Almut Schulze, Hai-Kun Liu
Recent advances in the genomics of glioblastoma (GBM) led to the introduction of molecular neuropathology but failed to translate into treatment improvement. This is largely attributed to the genetic and phenotypic heterogeneity of GBM, which are con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b3ee9c69783e22c4450a50222b77f27
https://doi.org/10.1101/2023.01.24.525374
https://doi.org/10.1101/2023.01.24.525374
Autor:
Hai-Kun Liu, Michael P. Moore, Tassia Mangetti Gonçalves, Naveen C. Reddy, James A. J. Fitzpatrick, Azad Bonni, Cole J. Ferguson, Mati Nemera, Harrison W. Gabel, Shahriyar P. Majidi, Lingchun Kong, Tomoko Yamada, Guoyan Zhao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Regulation of chromatin plays fundamental roles in the development of the brain. Haploinsufficiency of the chromatin remodeling enzyme CHD7 causes CHARGE syndrome, a genetic disorder that affects the development of the cerebellum. However, how CHD7 c