Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Hai-Kui Yang"'
Autor:
Rui-Qi Wang, Wei Zhao, Hai-Kui Yang, Jia-Mei Dong, Wei-Jie Lin, Fa-Zhong He, Min Cui, Zhi-Ling Zhou
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Colorectal cancer (CRC) manifests as gastrointestinal tumors with high intratumoral heterogeneity. Recent studies have demonstrated that CRC may consist of tumor cells with different consensus molecular subtypes (CMS). The advancements in single-cell
Externí odkaz:
https://doaj.org/article/c3fee79df1a54903a73211536d0a71db
Autor:
Hai-Kui Yang, Wei Zhao, Fazhong He, Rui-Qi Wang, Weijie Lin, Min Cui, Jia-Mei Dong, Zhiling Zhou
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
Colorectal cancer (CRC) manifests as gastrointestinal tumors with high intratumoral heterogeneity. Recent studies have demonstrated that CRC may consist of tumor cells with different consensus molecular subtypes (CMS). The advancements in single-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7cc6876e995e8a4cbd33d29e7f68101
https://doi.org/10.3389/fcell.2021.765578
https://doi.org/10.3389/fcell.2021.765578
Autor:
Rui-Qi, Wang, Fa-Zhong, He, Qian, Meng, Wei-Jie, Lin, Jia-Mei, Dong, Hai-Kui, Yang, Yang, Yang, Min, Zhao, Wen-Tao, Qiu, Yong-Jie, Xin, Zhi-Ling, Zhou
Publikováno v:
Ann Transl Med
BACKGROUND: Tribble pseudokinase 3 (TRIB3) plays a key role in regulating the malignancy of many tumors. This study examined its function in cancer cells and explored the potential mechanisms of action. METHODS: The expression of TRIB3 was examined i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56afb47aaa4cc80f217c6a376899bb38
https://pubmed.ncbi.nlm.nih.gov/34532390
https://pubmed.ncbi.nlm.nih.gov/34532390
Autor:
Lishun Zhang, Jiajie Zhang, Zhonghuang Li, Tingting Zhang, Xuan Xu, Shaoyu Wu, Zichao Yang, Shanhe Wan, Huiwu Zhang, Hai-Kui Yang, Yangcheng Ai
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 152
In this paper, we designed and synthesized two analog compounds M1 and T1 that have a Michael acceptor warhead. Although only slightly diversity existed in the structures of M1 and T1, their inhibitory activities against wild type epidermal growth fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6b21b9e817055787cf41d55e0aaacb
https://pubmed.ncbi.nlm.nih.gov/32668314
https://pubmed.ncbi.nlm.nih.gov/32668314
Publikováno v:
Future Medicinal Chemistry. 10:1705-1720
The abnormal expression of c-ros oncogene1 receptor tyrosine kinase (ROS1) has been identified as clinically actionable oncogenic driver in non-small-cell lung cancer. Since crizotinib was approved by the US FDA for the treatment of advanced ROS1-pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c19d38aa31f412e03a18e9b7e9fc71
https://doi.org/10.4155/fmc-2018-0033
https://doi.org/10.4155/fmc-2018-0033
Publikováno v:
ChemistryOpen. 7:447-456
The peptide segment of prostatic acid phosphatase (PAP248-286) aggregates to form SEVI (semen-derived enhancer of virus infection) amyloid fibrils. These are characteristic seminal amyloids that have the ability to promote the effect of HIV infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01c285d9756ff16f712bd48d5f13ae35
https://doi.org/10.1002/open.201800041
https://doi.org/10.1002/open.201800041
Autor:
Wentao Qiu, Fazhong He, Qian Meng, Zhiling Zhou, Jia-Mei Dong, Hai-Kui Yang, Rui-Qi Wang, Yong-Jie Xin, Yang Yang, Min Zhao, Weijie Lin
Publikováno v:
Annals of Translational Medicine. 9:1253-1253
Background Tribble pseudokinase 3 (TRIB3) plays a key role in regulating the malignancy of many tumors. This study examined its function in cancer cells and explored the potential mechanisms of action. Methods The expression of TRIB3 was examined in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b040cf992520105c1cc90d9ddf6808d
https://doi.org/10.21037/atm-21-2820
https://doi.org/10.21037/atm-21-2820
Publikováno v:
Chemical Papers. 72:651-659
As an aspect of our ongoing research on developing novel antiproliferative agents, 31 new triazole–isoindoline hybrids bearing 3,4,5-trimethoxyphenyl moiety were synthesized and evaluated for their antiproliferative activity against four cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344997af9358f0a69c3001fc825e4692
https://doi.org/10.1007/s11696-017-0311-8
https://doi.org/10.1007/s11696-017-0311-8
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3954-3958
Based on our previous work, a series of novel 2-amino-7,8-dihydropteridin-6(5H)-one derivatives were designed and synthesized via a ring-closing strategy. Biological evaluation with four human cancer cell lines (BT549, T47D, MDA-MB-468, and MDA-MB-23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c891a962d6fcd678a7d47f24cfbe7922
https://doi.org/10.1016/j.bmcl.2017.07.076
https://doi.org/10.1016/j.bmcl.2017.07.076
Publikováno v:
European Journal of Medicinal Chemistry. 125:1098-1106
Thirty-two novel 3-alkylsulfanyl-1,2,4-triazole derivatives, designed as cis-restricted combretastatin A-4 analogues, were synthesized and evaluated for their antiproliferative activities. The results indicated that analogue 20 showed more potent ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62cb29110456c6597314821dd8a5268
https://doi.org/10.1016/j.ejmech.2016.10.051
https://doi.org/10.1016/j.ejmech.2016.10.051