Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Hai Yun Xiao"'
Autor:
Aberra Fura, Shiuhang Yip, Georgia Cornelius, Hai-Yun Xiao, Qingjie Liu, Sha Li, Ning Li, Nicholas A. Meanwell, Shailesh Dudhgaonkar, Max Ruzanov, Jenny Xie, Zili Xiao, Purnima Khandelwal, Carolyn A. Weigelt, David J. Shuster, Dauh-Rurng Wu, T. G. Murali Dhar, Tara Sherry, Yang Michael G, Kevin Stefanski, Jignesh Nagar, Rex Denton, Qihong Zhao, Peng Li, Silvi A. Chacko, Arun Govindarajan, Robert M. Borzilleri, John S. Sack, Yeheng Zhu, Yunling Song, Dawn Sun, Anjuman Rudra, Mary T. Obermeier, Jinhong Wang, Douglas G. Batt, Venkata Murali
Publikováno v:
ACS Med Chem Lett
[Image: see text] Structure–activity relationship studies directed toward the replacement of the fused phenyl ring of the lead hexahydrobenzoindole RORγt inverse agonist series represented by 1 with heterocyclic moieties led to the identification
Autor:
Alaric J. Dyckman, Lois D. Lehman-McKeeman, Huadong Sun, Hong Shi, Mary Ellen Cvijic, Ding Ren Shen, Xiaoxia Yang, Michael Yang, Tracy L. Taylor, Hai-Yun Xiao, Zili Xiao, Luisa Salter-Cid, Jian Pang, Percy H. Carter, Paul Levesque, Arvind Mathur, John L. Gilmore, Jenny Xie, T. G. Murali Dhar, Georgia Cornelius, Anthony M. Marino, Kim W. McIntyre, Bethanne M. Warrack
Publikováno v:
Journal of Medicinal Chemistry. 64:1454-1480
Sphingosine-1-phosphate (S1P) binds to a family of sphingosine-1-phosphate G-protein-coupled receptors (S1P1-5). The interaction of S1P with these S1P receptors has a fundamental role in many physiological processes in the vascular and immune systems
Autor:
Mian Gao, David J. Shuster, Hai-Yun Xiao, Christine B. Goldstine, Jing Chen, Zhonghui Lu, Victor R. Guarino, Khehyong Ngu, Lisa M. Kopcho, Deepa Calambur, Kurt R. Gregor, Andrew J. Tebben, Jingwu Duan, Luisa Salter-Cid, Hao Lu, Joseph A. Tino, Ning Li, John Hynes, James R. Burke, Joseph Yanchunas, John E. Macor, Steven Sheriff, Dauh-Rurng Wu, Bin Jiang, Patrick J. Shaw, ChiehYing Y. Chang, Jenny Xie, Vojkan Susulic, T. G. Murali Dhar
Publikováno v:
Journal of Medicinal Chemistry. 63:15050-15071
Scaffold hopping and structure-based drug design were employed to identify substituted 4-aminoquinolines and 4-aminonaphthyridines as potent, small molecule inhibitors of tumor necrosis factor alpha (TNFα). Structure-activity relationships in both t
Autor:
John L. Gilmore, Kim W. McIntyre, Lois D. Lehman-McKeeman, David Marcoux, Hai-Yun Xiao, Georgia Cornelius, Alaric J. Dyckman, Mary Ellen Cvijic, Jenny Xie, Yang Michael G, T. G. Murali Dhar, Zili Xiao, Tracy L. Taylor, Anthony M. Marino, Ding Ren Shen, Percy H. Carter, Paul Levesque, Arvind Mathur, Huadong Sun, Hong Shi
Publikováno v:
ACS Med Chem Lett
[Image: see text] Efforts aimed at increasing the in vivo potency and reducing the elimination half-life of 1 and 2 led to the identification of aryl ether and thioether-derived bicyclic S1P(1) differentiated modulators 3–6. The effects of analogs
Autor:
Roshan G. Bhaskar, T. G. Murali Dhar, Martin P. Rauch, Hai Yun Xiao, Eric M. Simmons, Trevor C. Sherwood, Serge Zaretsky, Robert R. Knowles
Publikováno v:
The Journal of Organic Chemistry. 84:8360-8379
An intramolecular arene alkylation reaction has been developed using the organic photocatalyst 4CzIPN, visible light, and N-(acyloxy)phthalimides as radical precursors. Reaction conditions were optimized via high-throughput experimentation, and elect
Autor:
Lloyd Lecureux, Elizabeth M. Heimrich, Rochelle Thomas, Lois D. Lehman-McKeeman, Hai-Yun Xiao, Georgia Cornelius, Zheng Yang, Alaric J. Dyckman, Anuradha Gupta, Percy H. Carter, Yu-Wen Li, Paul Levesque, Tracy L. Taylor, Zili Xiao, Mary Ellen Cvijic, Arvind Mathur, John L. Gilmore, Lei Gong, Jenny Xie, Marta Dabros, Ding Ren Shen, Xiaoxia Yang, T. G. Murali Dhar, Xia D. Zhou, Yang Michael G, Bala Pragalathan, Huadong Sun, Anthony M. Marino, Hong Shi, Dauh-Rurng Wu, Richard Rampulla, Kim W. McIntyre, Cliff Chen, Luisa Salter-Cid, Bethanne M. Warrack, Celia D’Arienzo, Virna Borowski
Publikováno v:
Journal of Medicinal Chemistry. 62:2265-2285
Recently, our research group reported the identification of BMS-986104 (2) as a differentiated S1P1 receptor modulator. In comparison to fingolimod (1), a full agonist of S1P1 currently marketed for the treatment of relapse remitting multiple scleros
Autor:
John L, Gilmore, Hai-Yun, Xiao, T G Murali, Dhar, Michael, Yang, Zili, Xiao, Xiaoxia, Yang, Tracy L, Taylor, Kim W, McIntyre, Bethanne M, Warrack, Hong, Shi, Paul C, Levesque, Anthony M, Marino, Georgia, Cornelius, Arvind, Mathur, Ding Ren, Shen, Jian, Pang, Mary Ellen, Cvijic, Lois D, Lehman-McKeeman, Huadong, Sun, Jenny, Xie, Luisa, Salter-Cid, Percy H, Carter, Alaric J, Dyckman
Publikováno v:
Journal of medicinal chemistry. 64(3)
Sphingosine-1-phosphate (S1P) binds to a family of sphingosine-1-phosphate G-protein-coupled receptors (S1P
Autor:
Alaric Dyckman, Jenny Xie, Lois D Lehman-McKeeman, Marn Ellen Cvijic, Ding Ren Shen, Dauh-Rurng Wu, Arvind Mathur, Georgia Cornelius, Anthony Marino, Paul Levesque, Hong Shi, Andres Hernandez, David Marcoux, Michael Yang, T. G. Murali Dhar, Hai-Yun Xiao, John Lodge Gilmore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f19bf75ab5a1d51b52f15362ce3665
https://doi.org/10.1021/scimeetings.0c02440
https://doi.org/10.1021/scimeetings.0c02440
Autor:
Marta Dabros, Paul Levesque, Elizabeth M. Heimrich, Arvind Mathur, Percy H. Carter, Richard Rampulla, Anuradha Gupta, Lois D. Lehman-McKeeman, Huadong Sun, David Marcoux, Ding Ren Shen, Xiaoxia Yang, Xia D. Zhou, Hai-Yun Xiao, Dauh-Rurng Wu, Louis J. Lombardo, Hong Shi, Zheng Yang, Mary Ellen Cvijic, Alaric J. Dyckman, Kim W. McIntyre, Luisa Salter-Cid, Celia D’Arienzo, Anthony M. Marino, Bala Pragalathan, Georgia Cornelius, Jenny Xie, T. G. Murali Dhar, Tracy L. Taylor, Rochelle Thomas
Publikováno v:
MedChemComm. 8:725-729
Recently, our research group reported the identification of prodrug amino-alcohol 2 as a potent and efficacious S1P1 receptor modulator. This molecule is differentiated preclinically over the marketed drug fingolimod (Gilenya 1), whose active phospha
Autor:
Ding Ren Shen, Mary Ellen Cvijic, Hai-Yun Xiao, Alaric J. Dyckman, Yu-Wen Li, Bala Pragalathan, Joel C. Barrish, Georgia Cornelius, Peng Li, Tracy L. Taylor, Zili Xiao, Lois D. Lehman-McKeeman, Jianlin Feng, Dauh-Rurng Wu, John L. Gilmore, Percy H. Carter, David Marcoux, Zheng Yang, Arvind Mathur, Elizabeth M. Heimrich, Kim W. McIntyre, Bethanne M. Warrack, Anuradha Gupta, Yang Michael G, Luisa Salter-Cid, Praveen Balimane, Virna Borowski, Jenny Xie, T. G. Murali Dhar, Alda Fernandes, Anthony M. Marino
Publikováno v:
Journal of Medicinal Chemistry. 59:11138-11147
We describe a highly efficient route for the synthesis of 4a (BMS-986104). A key step in the synthesis is the asymmetric hydroboration of trisubstituted alkene 6. Particularly given the known difficulties involved in this type of transformation (6