Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Hai Ren Zhang"'
Autor:
Haiying Bao, Angela M. Lam, Shalini Bansal, Byoung-Kwon Chun, Michael J. Sofia, Holly M. Micolochick Steuer, Jinfa Du, Ying Jiang, Donghui Bao, Eisuke Murakami, Bruce S. Ross, Christine Espiritu, Michael J. Otto, Phillip A. Furman, Hai-Ren Zhang, P. Ganapati Reddy, Congrong Niu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5924-5929
The 3',5'-cyclic phosphate prodrug 9-[β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methylribofuranosyl]-2-amino-6-ethoxypurine, PSI-352938 1, has demonstrated promising anti-HCV efficacy in vitro and in human clinical trials. A structure-activity relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f3942cad5d386e93ff9eb0cf5dc9ab
https://doi.org/10.1016/j.bmcl.2012.07.066
https://doi.org/10.1016/j.bmcl.2012.07.066
Autor:
P. Ganapati Reddy, Darius Babusis, Angela M. Lam, Piyun B. Chao, Hai-Ren Zhang, Shalini Bansal, Yeojin Park, Phillip A. Furman, Eisuke Murakami, Wonsuk Chang, Congrong Niu, Haiying Bao, Michael J. Otto, Joseph Woolley, Adrian S. Ray, Li-Quan Wang, Tatiana Tolstykh, Jinfa Du, Michael J. Sofia
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:3767-3775
PSI-352938 is a novel cyclic phosphate prodrug of β- d -2′-deoxy-2′-α-fluoro-2′-β- C -methylguanosine-5′-monophosphate with potent anti-HCV activity. In order to inhibit the NS5B RNA-dependent RNA polymerase, PSI-352938 must be metabolized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da0bfffe81e52369ac0268db57f2fe8
https://doi.org/10.1128/aac.00530-12
https://doi.org/10.1128/aac.00530-12
Publikováno v:
The Journal of Organic Chemistry. 76:8311-8319
Prodrugs of therapeutic nucleoside monophosphates masked as phosphoramidate derivatives have become an increasingly important class of antiviral drugs in pharmaceutical research for delivering nucleotides in vitro and in vivo. Conventionally, phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be111622bb888beb7b2e90290cff94c3
https://doi.org/10.1021/jo201492m
https://doi.org/10.1021/jo201492m
Autor:
Holly M. Micolochick Steuer, Donghui Bao, Wonsuk Chang, Bruce S. Ross, Angela M. Lam, Shalini Bansal, Dhanapalan Nagarathnam, Michael J. Otto, P. Ganapati Reddy, Meg Keilman, Byoung-Kwon Chun, Congrong Niu, Hai-Ren Zhang, Rachakonda Suguna, Christine Espiritu, Phillip A. Furman, Jinfa Du, Michael J. Sofia
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7376-7380
A series of novel 2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs were synthesized and evaluated for their in vitro anti-HCV activity and safety. These prodrugs demonstrated a 10-100-fold greater potency than th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0894d7978cc2668811feded8aada3bad
https://doi.org/10.1016/j.bmcl.2010.10.035
https://doi.org/10.1016/j.bmcl.2010.10.035
Autor:
Jinfa Du, Angela M. Lam, Shalini Bansal, Rachakonda Suguna, Congrong Niu, Meg Keilman, Michael J. Otto, Donghui Bao, Bruce S. Ross, Peiyuan Wang, Dhanapalan Nagarathnam, Wonsuk Chang, Holly M. Micolochick Steuer, Michael J. Sofia, Hai-Ren Zhang, Phillip A. Furman, P. Ganapati Reddy, Christine Espiritu
Publikováno v:
Journal of Medicinal Chemistry. 53:7202-7218
Hepatitis C virus (HCV) is a global health problem requiring novel approaches for effective treatment of this disease. The HCV NS5B polymerase has been demonstrated to be a viable target for the development of HCV therapies. β-d-2'-Deoxy-2'-α-fluor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70b0f48ff595e61d3a04db4332b1530
https://doi.org/10.1021/jm100863x
https://doi.org/10.1021/jm100863x
Publikováno v:
The Journal of Organic Chemistry. 65:7977-7983
Treatment of 2-(1-alkynyl)phenyl isocyanates 6 with the iminophosphorane 14 produced in situ the benzoenynyl carbodiimides 15. Thermolysis of 15 under refluxing p-xylene furnished the 6H-indolo[2,3-b][1,6]naphthyridines 5, which could be regarded as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d6ad551fd96cdbb25f47c1c2059da1
https://doi.org/10.1021/jo000978e
https://doi.org/10.1021/jo000978e
Autor:
Kung K. Wang, Hai-Ren Zhang
Publikováno v:
The Journal of Organic Chemistry. 64:7996-7999
The C44H26 hydrocarbon 20 was synthesized in 13% overall yield in eight steps from acenaphthenequinone (6) and 2 equiv of 1-(2-ethynylphenyl)-2-phenylethyne. Condensation of the monoketal 7 with the lithium acetylide 8 afforded the benzoenediynyl pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00144cf571b54e782c81763d46eb5f5e
https://doi.org/10.1021/jo9911903
https://doi.org/10.1021/jo9911903
Publikováno v:
The Journal of Organic Chemistry. 64:1650-1656
Thermolysis of the benzoenyne-allene 20 in 1,4-cyclohexadiene (1,4-CHD) at 75 degrees C produced the cycloaromatized adduct 23 in 22% yield. The reaction presumably proceeds through a cascade sequence involving an initial Myers cyclization reaction t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e12450479e0bd255acfa9fa66699aec
https://doi.org/10.1021/jo982326k
https://doi.org/10.1021/jo982326k
Autor:
Ying Jiang, Jinfa Du, Hai-Ren Zhang, Christine Espiritu, Michael J. Sofia, Meg Keilman, Byoung-Kwon Chun, Phillip A. Furman, Wonsuk Chang, Donghui Bao, Bruce S. Ross, Holly M. Micolochick Steuer
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 30(11)
In order to support bioanalytical LC/MS method development and plasma sample analysis in preclinical and clinical studies of the anti-hepatitis C-virus nucleotides, PSI-7977 and PSI-352938, the corresponding stable isotope labeled forms were prepared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8220dcf677cd7fec510bfb2fdd8b18b
https://pubmed.ncbi.nlm.nih.gov/22060553
https://pubmed.ncbi.nlm.nih.gov/22060553
Autor:
Michael J. Sofia, Rachakonda Suguna, P. Ganapati Reddy, Byoung-Kwon Chun, Hai-Ren Zhang, Bruce S. Ross
Publikováno v:
The Journal of organic chemistry. 76(10)
PSI-352938 is a novel 2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug currently under investigation for the treatment of hepatitis C virus (HCV) infection. PSI-352938 demonstrated superior characteristics in vitro that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c540fb4f9d89857730dcde202e205b
https://pubmed.ncbi.nlm.nih.gov/21469736
https://pubmed.ncbi.nlm.nih.gov/21469736