Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hai Qiu Wu"'
Publikováno v:
Biochemical Society Transactions
Biochemical Society Transactions, 48(2), 479-497. PORTLAND PRESS LTD
Biochemical Society Transactions, 48(2), 479-497. PORTLAND PRESS LTD
Eukaryotic life depends upon the interplay between vast networks of signaling pathways composed of upwards of 109–1010 proteins per cell. The integrity and normal operation of the cell requires that these proteins act in a precise spatial and tempo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1365d74b0f4f4bf74d5980fd2f8242d0
https://hdl.handle.net/1887/3181189
https://hdl.handle.net/1887/3181189
Autor:
Hai-Qiu Wu, Changchun Wang
Publikováno v:
Langmuir. 32:6211-6225
Nanogels (or nanohydrogels) have been extensively investigated as one of the most promising nanoparticulate biomedical platforms owing to their advantageous properties that combine the characteristics of hydrogel systems with nanoparticles. Among the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa98492321a67dec6cce58eff87b96b8
https://doi.org/10.1021/acs.langmuir.6b00842
https://doi.org/10.1021/acs.langmuir.6b00842
Autor:
Fen-Er Chen, Erik De Clercq, Christophe Pannecouque, Jin Yao, Wen-Xue Chen, Hai-Qiu Wu, Qiu-Qin He, Dirk Daelemans
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:624-631
A series of new DAPY-DPEs hybrids, combined the important pharmacophores of DAPYs and DPEs, has been synthesized and biologically evaluated for their anti-HIV activities against wild-type HIV-1 strain IIIB, double RT mutant (K103N+Y181C) strain RES05
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34601d495a86ce6859e5b27548fec71
https://doi.org/10.1016/j.bmc.2014.11.032
https://doi.org/10.1016/j.bmc.2014.11.032
Autor:
Hai-Qiu Wu, Wen-Xue Chen, Fen-Er Chen, Yan Wu, Zi-Hong Yan, Hu-Ri Piao, Qiu-Qin He, Erik De Clercq, Christophe Pannecouque
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:3220-3226
A series of new diarylpyrimidines (DAPYs) characterized by a halogen atom on the methylene linker between wing I and the central pyrimidine ring was synthesized and evaluated for their anti-HIV activity in MT-4 cell cultures. The two most promising c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f071a7bfa82d254a25eae8ab4187a79
https://doi.org/10.1016/j.bmc.2014.03.020
https://doi.org/10.1016/j.bmc.2014.03.020
Publikováno v:
Biochemical Society Transactions; Apr2020, Vol. 48 Issue 2, p479-497, 19p
Autor:
Wen-Xue Chen, Zi-Hong Yan, Jan Balzarini, Christophe Pannecouque, Fen-Er Chen, Hai-Qiu Wu, Erik De Clercq, Qiu-Qin He, Dirk Daelemans
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:6477-6483
A series of C6-rigid S-DABO analogs characterized by a substituted benzoyl group at C6 position of the pyrimidine ring has been synthesized and biological evaluation as NNRTIs against wild-type HIV-1 strain IIIB, double RT mutant (K103N + Y181C) stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6867634b0943d361fcb24c780bcf0dfe
https://doi.org/10.1016/j.bmc.2013.08.040
https://doi.org/10.1016/j.bmc.2013.08.040
Publikováno v:
SAR and QSAR in environmental research. 25(10)
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) play a significant role in anti-HIV drug development. A series of naphthyl-substituted diarylpyrimidines with most EC50 values in the nanomolar range was reported as potent NNRTIs by our lab. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a13ade5402959fcac0069a188727016
https://pubmed.ncbi.nlm.nih.gov/25242254
https://pubmed.ncbi.nlm.nih.gov/25242254
Autor:
Xiayun Huang, Wen-Xue Chen, Zi-Hong Yan, Christophe Pannecouque, Fen-Er Chen, Hai-Qiu Wu, Erik De Clercq, Qiu-Qin He
Publikováno v:
Bioorganicmedicinal chemistry. 22(8)
A series of CR 2 (OH)-diarylpyrimidine derivatives (CR 2 (OH)-DAPYs) featuring a hydrophobic group at CH(OH) linker between wing I and the central pyrimidine were synthesized and evaluated for their anti-HIV activity in MT-4 cell cultures. All the ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef278922c676d7bcb8bc0263997b379d
https://pubmed.ncbi.nlm.nih.gov/24680058
https://pubmed.ncbi.nlm.nih.gov/24680058
Autor:
Hai-Qiu Wu, Liu-Meng Yang, Xuan Zhang, Yong-Tang Zheng, Shuang-Xi Gu, Fen-Er Chen, Qiu-Qin He, Xiao-Dong Ma
Publikováno v:
Bioorganicmedicinal chemistry. 19(18)
A series of new 5-hydroxylquinolone-3-carboxylic acids (HQCAs) with various aryl or benzyl substituents on N-1 position were synthesized and evaluated for their anti-HIV activity in C8166 cell culture. Most of the target compounds displayed activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0108ee580b3ddf161719700ac2d9d00
https://pubmed.ncbi.nlm.nih.gov/21862337
https://pubmed.ncbi.nlm.nih.gov/21862337
Autor:
Fen-Er Chen, Hai-Qiu Wu, Liu-Meng Yang, Xuan Zhang, Yong-Tang Zheng, Qiu-Qin He, Jia Liu, Shuang-Xi Gu
Publikováno v:
Bioorganicmedicinal chemistry. 19(16)
A series of new quinolone-3-carboxylic acids featuring a hydroxyl group at C-5 position were synthesized and evaluated for their in vitro activity against HIV in C8166 cell culture. All the compounds showed anti-HIV-1 activity with low micromolar to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced23e1ba92a3b7eb01b6fcb62c74b1c
https://pubmed.ncbi.nlm.nih.gov/21763149
https://pubmed.ncbi.nlm.nih.gov/21763149