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Autor:
John H. Connor, Sailen Barik, Shirish Shenolikar, Jianhong Zheng, Hai N. Quan, John F. Cannon, Lifang Zhang, Ernest Y.C. Lee, Nadja T. Ramaswamy
Publikováno v:
The Journal of biological chemistry. 273(42)
Inhibitor-1 (I-1), a cyclic AMP-regulated phosphoprotein, inhibits protein phosphatase-1 (PP1) activity in response to hormones. The molecular mechanism for PP1 inhibition by I-1 remains unknown. Mutation of nine acidic residues lining a proposed I-1