Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Hai Bing Zhou"'
Autor:
Yubo Wang, Jian Min, Xiangping Deng, Tian Feng, Hebing Hu, Xinyi Guo, Yan Cheng, Baohua Xie, Yu Yang, Chun-Chi Chen, Rey-Ting Guo, Chune Dong, Hai-Bing Zhou
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 12, Pp 4963-4982 (2023)
Endocrine-resistance remains a major challenge in estrogen receptor α positive (ERα+) breast cancer (BC) treatment and constitutively active somatic mutations in ERα are a common mechanism. There is an urgent need to develop novel drugs with new m
Externí odkaz:
https://doaj.org/article/f84e6d8203d24831bb9c9b09d3cda2b2
Publikováno v:
Cell Insight, Vol 2, Iss 3, Pp 100092- (2023)
Proteolysis targeting chimera (PROTAC) degradation of pathogenic proteins by hijacking of the ubiquitin-proteasome-system has become a promising strategy in drug design. The overwhelming advantages of PROTAC technology have ensured a rapid and wide u
Externí odkaz:
https://doaj.org/article/df2437e043c9498a8d0019586d0ffaa6
Autor:
Zhichao Xu, Xinjin Liu, Xiaoyu Ma, Wenting Zou, Qi Chen, Feifei Chen, Xiaofei Deng, Jinsen Liang, Chune Dong, Ke Lan, Shuwen Wu, Hai-Bing Zhou
Publikováno v:
Cell Insight, Vol 1, Iss 3, Pp 100030- (2022)
Annual and sporadic influenza outbreaks pose a great threat to human health and the economy worldwide. Moreover, the frequent mutation of influenza viruses caused by antigen drift complicates the application of antiviral therapeutics. As such, there
Externí odkaz:
https://doaj.org/article/f54635140a86469d871bf761905de2e3
Autor:
Qi Tang, Zhichao Xu, Fan Zhang, Yang Cai, Yinuo Chen, Baojing Lu, Hai-bing Zhou, Ke Lan, Shuwen Wu
Publikováno v:
Cell Insight, Vol 1, Iss 2, Pp 100016- (2022)
Enterovirus 71 (EV-A71) infection causes severe hand-foot-and-mouth disease that leads to cardiopulmonary complications and death in young children under 5 years of age. Although there are available vaccines for EV-A71 C4, however, there are no effic
Externí odkaz:
https://doaj.org/article/bd8367c05f39493b903f0a99e8da58ac
Autor:
Baohua Xie, Zhinang Yin, Zhiye Hu, Junhui Lv, Chuanqian Du, Xiangping Deng, Yuan Huang, Qiuzi Li, Jian Huang, Kaiwei Liang, Hai-Bing Zhou, Chune Dong
Publikováno v:
Journal of Medicinal Chemistry. 66:6631-6651
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e3ffdb46fbe03af5a4dda7686a25cdb
https://doi.org/10.1021/acs.jmedchem.2c02032
https://doi.org/10.1021/acs.jmedchem.2c02032
Autor:
Min Qiu, Zhinang Yin, Honghong Wang, Lingyu Lei, Conghui Li, Yali Cui, Rong Dai, Peiyuan Yang, Ying Xiang, Qiuzi Li, Junhui Lv, Zhuang Hu, Min Chen, Hai-Bing Zhou, Pingping Fang, Ruijing Xiao, Kaiwei Liang
Publikováno v:
Science Advances. 9
Cyclin-dependent kinase 12 (CDK12) interacts with cyclin K to form a functional nuclear kinase that promotes processive transcription elongation through phosphorylation of the C-terminal domain of RNA polymerase II (Pol II). To gain a comprehensive u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f34e9497f2b4bf10a5cd7f663fc8d9e0
https://doi.org/10.1126/sciadv.adf8698
https://doi.org/10.1126/sciadv.adf8698
Autor:
Jerome C Nwachukwu, Sathish Srinivasan, Yangfan Zheng, Song Wang, Jian Min, Chune Dong, Zongquan Liao, Jason Nowak, Nicholas J Wright, René Houtman, Kathryn E Carlson, Jatinder S Josan, Olivier Elemento, John A Katzenellenbogen, Hai‐Bing Zhou, Kendall W Nettles
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 4, Pp 1-14 (2016)
Abstract Some estrogen receptor‐α (ERα)‐targeted breast cancer therapies such as tamoxifen have tissue‐selective or cell‐specific activities, while others have similar activities in different cell types. To identify biophysical determinants
Externí odkaz:
https://doaj.org/article/cf1c1a8640554626b04f8b7d235ebf06
Autor:
Xinjin Liu, Jinsen Liang, Yongshi Yu, Xin Han, Lei Yu, Feifei Chen, Zhichao Xu, Qi Chen, Mengyu Jin, Chune Dong, Hai-Bing Zhou, Ke Lan, Shuwen Wu
Publikováno v:
Journal of Medicinal Chemistry. 65:3814-3832
Influenza A viruses possess a high antigenic shift, and the approved anti-influenza drugs are extremely limited, which makes the development of novel anti-influenza drugs for the clinical treatment and prevention of influenza outbreaks imperative. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2f298827f436c37b31fc6bcf1488cb
https://doi.org/10.1021/acs.jmedchem.1c01257
https://doi.org/10.1021/acs.jmedchem.1c01257
Publikováno v:
ACS Sensors. 7:109-115
Estrogen receptor β (ERβ) is associated with many diseases, and ERβ probes can help to reveal the complex role of ERβ and promote the development of ERβ-targeted therapy. Herein, we designed and synthesized the first ERβ-targeted near-infrared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52f1b4d82c2b86c1439c508ce97cf31
https://doi.org/10.1021/acssensors.1c01771
https://doi.org/10.1021/acssensors.1c01771
Publikováno v:
Biochemical and Biophysical Research Communications. 573:69-75
Breast cancer (BRCA) is one of the most threatening cancer types, especially among the female population. 70% of breast cancer are estrogen receptor α (ERα) positive and endocrine therapy is effective to decrease breast cancer risk. Autophagy, a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4295be1961b35b86b1904c30f8f8eda6
https://doi.org/10.1016/j.bbrc.2021.08.013
https://doi.org/10.1016/j.bbrc.2021.08.013