Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Hai Bin Luo"'
Autor:
Cheng-Mei Huang, Kai-Chao Wu, Krishan K. Verma, Hai-Bin Luo, Zhi-Nian Deng, Guo-Ying Shi, Hui-Qing Cao, Xing-Jian Wu, Li-Ping Ye, Yuan-Wen Wei, Lin Xu
Publikováno v:
Chemical and Biological Technologies in Agriculture, Vol 11, Iss 1, Pp 1-16 (2024)
Abstract Plant cellulose synthase is one of the important glycosyltransferases, which catalyzes the synthesis of the paracrystalline of H-bonded-β-(1,4)-glucose chains. This study isolated the cellulose synthase 3 (Ces3) sequence from sugarcane (Sac
Externí odkaz:
https://doaj.org/article/25bc3011606e4d9b9b4cac8ecf0f4110
Autor:
Xia Li, Shihao Song, Xiaohan Kong, Xiayu Chen, Zhuoxian Zhao, Zizi Lin, Yantao Jia, Yong Zhang, Hai-Bin Luo, Qiao-Ping Wang, Lian-Hui Zhang, Wei Qian, Yinyue Deng
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114223- (2024)
Summary: Quorum sensing (QS) is a cell-to-cell communication mechanism mediated by small diffusible signaling molecules. Previous studies showed that RpfR controls Burkholderia cenocepacia virulence as a cis-2-dodecenoic acid (BDSF) QS signal recepto
Externí odkaz:
https://doaj.org/article/20a12a148d864005b667279033d32328
Autor:
Qian Zhou, Meiling Le, Yiyi Yang, Wenjuan Wang, Yuqi Huang, Quan Wang, Yijing Tian, Meiyan Jiang, Yong Rao, Hai-Bin Luo, Yinuo Wu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 3, Pp 1180-1191 (2023)
Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therape
Externí odkaz:
https://doaj.org/article/89a692e5759540968ac18e77b2bc7922
Autor:
Zheng-Wei Zhang, Chun-Sheng Gao, Heng Zhang, Jian Yang, Ya-Ping Wang, Li-Bin Pan, Hang Yu, Chi-Yu He, Hai-Bin Luo, Zhen-Xiong Zhao, Xin-Bo Zhou, Yu-Li Wang, Jie Fu, Pei Han, Yu-Hui Dong, Gang Wang, Song Li, Yan Wang, Jian-Dong Jiang, Wu Zhong
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 8, Pp 3298-3312 (2022)
Morinda officinalis oligosaccharides (MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted
Externí odkaz:
https://doaj.org/article/550caaf00dce49ea8a24e4a2f2b15517
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 7, Pp 3103-3112 (2022)
Our previous study demonstrated that phosphodiesterase 8 (PDE8) could work as a potential target for vascular dementia (VaD) using a chemical probe 3a. However, compound 3a is a chiral compound which was obtained by chiral resolution on HPLC, restric
Externí odkaz:
https://doaj.org/article/41071af6cb6b437b842e31db8dbdb293
Autor:
Zhiwei Xiao, Huiyi Wei, Yi Xu, Ahmed Haider, Junjie Wei, Shiyu Yuan, Jian Rong, Chunyu Zhao, Guocong Li, Weibin Zhang, Huangcan Chen, Yuefeng Li, Lingling Zhang, Jiyun Sun, Shaojuan Zhang, Hai-Bin Luo, Sen Yan, Qijun Cai, Lu Hou, Chao Che, Steven H. Liang, Lu Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1963-1975 (2022)
As a member of cyclic nucleotide phosphodiesterase (PDE) enzyme family, PDE10A is in charge of the degradation of cyclic adenosine (cAMP) and guanosine monophosphates (cGMP). While PDE10A is primarily expressed in the medium spiny neurons of the stri
Externí odkaz:
https://doaj.org/article/dbe615a754e04340924e1a3797b18488
Autor:
Deyan Wu, Xuehua Zheng, Runduo Liu, Zhe Li, Zan Jiang, Qian Zhou, Yue Huang, Xu-Nian Wu, Chen Zhang, Yi-You Huang, Hai-Bin Luo
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 1351-1362 (2022)
Scaffold hopping refers to computer-aided screening for active compounds with different structures against the same receptor to enrich privileged scaffolds, which is a topic of high interest in organic and medicinal chemistry. However, most approache
Externí odkaz:
https://doaj.org/article/35e8bd3e764c47488baa224bfba360df
Autor:
Guoyou Xie, Xu-Nian Wu, Yuyi Ling, Yalan Rui, Deyan Wu, Jiawang Zhou, Jiexin Li, Shuibin Lin, Qin Peng, Zigang Li, Hongsheng Wang, Hai-Bin Luo
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 2, Pp 853-866 (2022)
N6-methyladenosine (m6A) modification is critical for mRNA splicing, nuclear export, stability and translation. Fat mass and obesity-associated protein (FTO), the first identified m6A demethylase, is critical for cancer progression. Herein, we develo
Externí odkaz:
https://doaj.org/article/4b8e146bd58b4541a8de83b4515af059
Autor:
Kai-Chao Wu, Cheng-Mei Huang, Krishan K. Verma, Zhi-Nian Deng, Hai-Rong Huang, Tian Pang, Hui-Qing Cao, Hai-Bin Luo, Sheng-Li Jiang, Lin Xu
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
Drought is the abiotic factor that adversely affects plant growth, development survival, and crop productivity, posing a substantial threat to sustainable agriculture worldwide, especially in warm and dry areas. However, the extent of damage depends
Externí odkaz:
https://doaj.org/article/e0b26828ed344ab0a8c6e81eb2287e27
Autor:
Yuncong Yang, Sirui Zhang, Qian Zhou, Chen Zhang, Yuqi Gao, Hao Wang, Zhe Li, Deyan Wu, Yinuo Wu, Yi-You Huang, Lei Guo, Hai-Bin Luo
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2339-2347 (2020)
Optimization efforts were devoted to discover novel PDE10A inhibitors in order to improve solubility and pharmacokinetics properties for a long-term therapy against pulmonary arterial hypertension (PAH) starting from the previously synthesized inhibi
Externí odkaz:
https://doaj.org/article/ccae75c50048476bb23a4e31a9cef74b