Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Hahk‐Soo Kang"'
Autor:
Yoon-Hee Chung, Hiyoung Kim, Chang-Hun Ji, Hyun-Woo Je, Dongho Lee, Sang Hee Shim, Hwang-Soo Joo, Hahk-Soo Kang
Publikováno v:
mSystems, Vol 6, Iss 4 (2021)
ABSTRACT The genus Streptomyces is one of the richest sources of secondary metabolite biosynthetic gene clusters (BGCs). Sequencing of a large number of genomes has provided evidence that this well-known bacterial genus still harbors a large number o
Externí odkaz:
https://doaj.org/article/5b828227cdd7428480e0ceae59f7e941
Autor:
Jin Won Choi, Yeonhee Lee, Jaekyeong Kim, Haeun Kwon, Stephen T. Deyrup, Jin Woo Lee, Dongho Lee, Hahk-soo Kang, Hwangsoo Joo, Sang Hee Shim
Publikováno v:
Journal of Natural Products. 86:947-957
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8439f1ae92f3c39019d2dfa3f5c4da23
https://doi.org/10.1021/acs.jnatprod.2c01151
https://doi.org/10.1021/acs.jnatprod.2c01151
Autor:
Hyeri, Ku, Yeonhee, Lee, Seungjin, Lee, Jin Woo, Lee, Hahk-Soo, Kang, Hwang-Soo, Joo, Sang Hee, Shim
Publikováno v:
The Journal of Antibiotics. 76:57-64
Two new berkeley meroterpenoids (1 and 2), along with seven known compounds (3‒9) were isolated from a fungus, Penicillium sp. SSW03M2 GY derived from a sediment at Seosan bay, South Korea. Chemical structures of the isolated compounds were elucida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f97545cd18044b7f9d80b50a30f427
https://doi.org/10.1038/s41429-022-00587-7
https://doi.org/10.1038/s41429-022-00587-7
Publikováno v:
ACS Synthetic Biology. 12:61-70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d2a5b1b5be20b977927b471cb67d3b9
https://doi.org/10.1021/acssynbio.2c00539
https://doi.org/10.1021/acssynbio.2c00539
Publikováno v:
Metabolic Engineering. 69:40-49
Secondary metabolites are produced at low titers by native producers due to tight regulations of their productions in response to environmental conditions. Synthetic biology provides a rational engineering principle for transcriptional optimization o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f534ba99e7c8dbb2ff404cf9275d440b
https://doi.org/10.1016/j.ymben.2021.10.013
https://doi.org/10.1016/j.ymben.2021.10.013
Autor:
Hahk-Soo Kang, Dongho Lee, Hiyoung Kim, Chang-Hun Ji, Sang Hee Shim, Yoon-Hee Chung, Hyun-Woo Je, Hwang-Soo Joo
Publikováno v:
mSystems
mSystems, Vol 6, Iss 4 (2021)
mSystems, Vol 6, Iss 4 (2021)
The genus Streptomyces is one of the richest sources of secondary metabolite biosynthetic gene clusters (BGCs). Sequencing of a large number of genomes has provided evidence that this well-known bacterial genus still harbors a large number of cryptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3794c638839df064b7e475e47db2ba11
http://europepmc.org/articles/PMC8407293
http://europepmc.org/articles/PMC8407293
Publikováno v:
ACS Synthetic Biology. 9:175-180
Multiplexed refactoring provides a tool for rapid transcriptional optimization of biosynthetic gene clusters (BGCs) through simultaneous replacement of multiple native promoters with synthetic counterparts. Here, we present the mpCRISTAR, a multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22af9ce81dd5260158b7a6ac5c438722
https://doi.org/10.1021/acssynbio.9b00382
https://doi.org/10.1021/acssynbio.9b00382
Publikováno v:
ACS Synthetic Biology. 8:577-586
Biosynthesis of secondary metabolites is a highly complex process that often requires tight control of their production, as overproduction of metabolites could be toxic and also may cause metabolic burden to their hosts. Tight control of metabolite p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa31ea82e67d469cceee2939cd375e1
https://doi.org/10.1021/acssynbio.9b00001
https://doi.org/10.1021/acssynbio.9b00001
Autor:
Eung-Soo Kim, Hahk-Soo Kang
Publikováno v:
Current opinion in biotechnology. 69
The heterologous expression of natural product biosynthetic gene clusters (BGCs) has traditionally been used as a genetic platform to link various natural product chemotypes to their corresponding genotypes. In recent years, heterologous expression h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fcacb449fcdd1bbf17a9bb06e52016
https://pubmed.ncbi.nlm.nih.gov/33445072
https://pubmed.ncbi.nlm.nih.gov/33445072
Publikováno v:
ACS Synthetic Biology. 7:1946-1955
Promoter engineering has emerged as a powerful tool to activate transcriptionally silent natural product biosynthetic gene clusters found in bacterial genomes. Since biosynthetic gene clusters are composed of multiple operons, their promoter engineer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e16b50c9f69689461831bd78eb7cae
https://doi.org/10.1021/acssynbio.8b00175
https://doi.org/10.1021/acssynbio.8b00175