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pro vyhledávání: '"Hague, James P"'
Autor:
Hague, James P.
Understanding of vascular organization is a long-standing problem in quantitative biology and biophysics and is essential for the growth of large cultured tissues. Approaches are needed that (1) make predictions of optimal arteriovenous networks in o
Externí odkaz:
http://arxiv.org/abs/2308.02700
The technique presented here identifies tethered mould designs, optimised for growing cultured tissue with very highly-aligned cells. It is based on a microscopic biophysical model for polarised cellular hydrogels. There is an unmet need for tools to
Externí odkaz:
http://arxiv.org/abs/2306.13435
The interactions between cells and the extracellular matrix are vital for the self-organisation of tissues. In this paper we present proof-of-concept to use machine learning tools to predict the role of this mechanobiology in the self-organisation of
Externí odkaz:
http://arxiv.org/abs/2303.18017
Autor:
Hague, James P., Keelan, Jonathan, Beishon, Lucy, Swienton, David, Robinson, Thompson G., Chung, Emma M. L.
There is a need to develop Monte Carlo simulations of stroke to run in-silico trials to replace animal models, explore clinical scenarios to develop hypotheses for clinical studies and for interpreting clinical monitoring. We perform three-dimensiona
Externí odkaz:
http://arxiv.org/abs/2110.15141
Autor:
Keelan, Jonathan, Hague, James P.
We examine the role of complexity on arterial tree structures, determining globally optimal vessel arrangements using the Simulated AnneaLing Vascular Optimization (SALVO) algorithm, which we have previously used to reproduce features of cardiac and
Externí odkaz:
http://arxiv.org/abs/2007.07039
The cerebral arteries are difficult to reproduce from first principles, featuring interwoven territories, and intricate layers of grey and white matter with differing metabolic demand. The aim of this study was to identify the ideal configuration of
Externí odkaz:
http://arxiv.org/abs/1807.11513
Autor:
Patel, Nikil, Banahan, Caroline, Janus, Justyna, Horsfield, Mark A., Cox, Anthony, Marshall, David, Colman, Jordan, Morlese, John, Evans, David H., Hannon, Claire, Egan, Vincent, Garrard, Peter, Hague, James P., Chung, Emma M.L.
Publikováno v:
In Journal of the Neurological Sciences 15 September 2020 416
Does the complex processes of angiogenesis during organism development ultimately lead to a near optimal coronary vasculature in the organs of adult mammals? We examine this hypothesis using a powerful and universal method, built on physical and phys
Externí odkaz:
http://arxiv.org/abs/1403.6450
Autor:
Hague, James P.1 (AUTHOR) Jim.Hague@open.ac.uk, Keelan, Jonathan1 (AUTHOR), Beishon, Lucy2 (AUTHOR), Swienton, David3 (AUTHOR), Robinson, Thompson G.4 (AUTHOR), Chung, Emma M. L.2,5,6 (AUTHOR)
Publikováno v:
Scientific Reports. 2/21/2023, Vol. 13 Issue 1, p1-9. 9p.