Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hagit Shulman"'
Publikováno v:
Chemistry - A European Journal. 10:2159-2165
+ ) Incumbent of the Benno Gitter & Ilana Ben-Ami chair of Biotech- nology, Technion. Abstract: Aldolase antibody 24H6, which was obtained by reactive immu- nization against a 1,3-diketone hapten, is shown to catalyze additional reac- tions, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2c80a192c98cf3c3b8722d87c66dad
https://doi.org/10.1002/chem.200305034
https://doi.org/10.1002/chem.200305034
Publikováno v:
Chemistry - A European Journal. 8:229-239
Antibody 38C2 efficiently catalyzes deuterium-exchange reactions at the position of a variety of ketones and aldehydes, including substrates that have a variety of sensitive functional groups. In addition to the regio- and chemoselectivity of these r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611ae7b90eb0332fa40e772494720bb5
https://doi.org/10.1002/1521-3765(20020104)8:1<229::aid-chem229>3.0.co
https://doi.org/10.1002/1521-3765(20020104)8:1<229::aid-chem229>3.0.co
Publikováno v:
Journal of the American Chemical Society. 122:10743-10753
An aldolase antibody, 24H6, which was obtained from immunization with the large hapten 2, is shown to possess an active-site lysine residue with a perturbed pKa of 7.0. This antibody catalyzes both the aldol addition and the retrograde aldol fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bf7506818e501e7e3fd6ee2d7ad01bc
https://doi.org/10.1021/ja000616o
https://doi.org/10.1021/ja000616o
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::345628f470c703ef2035aa6d45852ade
https://doi.org/10.1002/chin.199847041
https://doi.org/10.1002/chin.199847041
Publikováno v:
ChemInform. 33
Antibody 38C2 efficiently catalyzes deuterium-exchange reactions at the position of a variety of ketones and aldehydes, including substrates that have a variety of sensitive functional groups. In addition to the regio- and chemoselectivity of these r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c45222eb50df8658d4305724dca1c30b
https://doi.org/10.1002/chin.200219066
https://doi.org/10.1002/chin.200219066
Autor:
Ehud Keinan, Hagit Shulman
Publikováno v:
Organic letters. 2(23)
Commercially available coals were found to be efficient heterogeneous catalysts of the Kemp elimination reaction in aqueous solutions. A pH-rate profile study suggests that catalysis originates from specific catalytic groups and not simply from the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71a0cdaaa3bd9184c0c1b191a3c9e92
https://pubmed.ncbi.nlm.nih.gov/11073691
https://pubmed.ncbi.nlm.nih.gov/11073691
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(20)
A highly sensitive, inexpensive, and facile bioluminescent assay for the detection of catalytic antibodies has been developed. This assay may be used for the early detection of antibody catalysis. The efficiency of this technique was exemplified by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cd9ead2ae5d7005caaa76deefe0e57
https://pubmed.ncbi.nlm.nih.gov/11055354
https://pubmed.ncbi.nlm.nih.gov/11055354
Autor:
Hagit Shulman, Ehud Keinan
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(13)
A structure-activity relationship study with a series of aldol substrates shows that the mechanism of the antibody 38C2-catalyzed retrograde aldol reaction depends on the nature of the substrate With electron-deficient substrates an early deprotonati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1fa2b73ca7963b426474babbecf92f
https://pubmed.ncbi.nlm.nih.gov/10406635
https://pubmed.ncbi.nlm.nih.gov/10406635
Publikováno v:
Chemical Communications. :1759-1760
Antibody 14D9, which catalyzes the stereoselective transformation of achiral enol ethers into the corresponding (S)-ketals, resolves a racemic mixture of structurally similar chiral enol ethers by selective conversion of the (R)-enol ether into the (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25d6fb5b15d85de571fc104ed474a0d7
https://doi.org/10.1039/a802374c
https://doi.org/10.1039/a802374c
Publikováno v:
Chemistry - A European Journal; 5/3/2004, Vol. 10 Issue 9, p2159-2165, 7p