Polydopamine Copolymers for Stable Drug Nanoprecipitation

Autor: Danna Niezni, Yuval Harris, Hagit Sason, Maytal Avrashami, Yosi Shamay

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 20, p 12420 (2022)

Polydopamine (PDA), a biomaterial inspired by marine mussels, has attracted interest in cancer nanomedicine due to its photothermal properties, nanoparticle coating, and pi-pi stacking-based drug encapsulation abilities. Despite numerous one-pot and

Externí odkaz: https://doaj.org/article/507734884655434caf3a5e1e5434878e

Extending the Boundaries of Cancer Therapeutic Complexity with Literature Data Mining

Autor: Danna Niezni, Hillel Taub-Tabib, Yuval Harris, Hagit Sason-Bauer, Yakir Amrusi, Dana Azagury, Maytal Avrashami, Shaked Launer-Wachs, Jon Borchardt, M Kusold, Aryeh Tiktinsky, Tom Hope, Yoav Goldberg, Yosi Shamay

Drug combination therapy is a main pillar of cancer therapy but the formation of an effective combinatorial standard of care (SOC) can take many years and its length of development is increasing with complexity of treatment. In this paper, we develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec39081c65122e24e8f7d4a83cc4f11b
https://doi.org/10.1101/2022.05.03.490286

Asc-1 transporter regulation of synaptic activity via the tonic release of D-serine in the forebrain

Autor: Hazem Safory, Eitan Kaplan, Jean-Marie Billard, Christoffer Bundgaard, Christian Thomsen, Avi Avital, Hagit Sason, Salman Zubedat, Samah Neame, Kenneth Vielsted Christensen, Dina Rosenberg, Claus Tornby Christoffersen, Garrick Paul Smith, Herman Wolosker, Veronika N. Foltyn

Publikováno v: Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2017, 27 (2), pp.1573-1587. ⟨10.1093/cercor/bhv350⟩
Cerebral Cortex, Oxford University Press (OUP), 2017, 27, pp.1573-1587. ⟨10.1177/0271678X15626718⟩

d-Serine is a co-agonist of NMDA receptors (NMDARs) whose activity is potentially regulated by Asc-1 (SLC7A10), a transporter that displays high affinity for d-serine and glycine. Asc-1 operates as a facilitative transporter and as an antiporter, tho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e811a43353d2e0dd0cbd67c9faf985c
https://hal-normandie-univ.archives-ouvertes.fr/hal-02325027

EnteropathogenicEscherichia coliSubverts Phosphatidylinositol 4,5-Bisphosphate and Phosphatidylinositol 3,4,5-Trisphosphate upon Epithelial Cell Infection

Autor: Tamas Balla, Aryeh Weiss, Ilan Rosenshine, Naomi Melamed-Book, Hagit Sason, Benjamin Aroeti, Sergio Grinstein, Steffen Backert, Michal Milgrom

Publikováno v: Molecular Biology of the Cell. 20:544-555

Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] are phosphoinositides (PIs) present in small amounts in the inner leaflet of the plasma membrane (PM) lipid bilayer of host target cells. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e526dfbedc0acd48a584e158f0796e
https://doi.org/10.1091/mbc.e08-05-0516

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

Autor: Rajesh Ambasudhan, Emily A. Holland, Yeon-Joo Kang, Evan T. Powers, Traci Fang-Newmeyer, Peng Xia, Amanda J. Roberts, James P. Solomon, Herman Wolosker, Nobuki Nakanishi, Xiaofei Zhang, Shichun Tu, Gustavo Dziewczapolski, Loren H. Parsons, Dongxian Zhang, Stephen F. Heinemann, Mohd Waseem Akhtar, H.-S. Vincent Chen, Juan C. Piña-Crespo, Alexander E. Pratt, Eliezer Masliah, Scott R. McKercher, James C. Parker, Gang Cao, Sarah Michael, Shu-ichi Okamoto, Sara Sanz-Blasco, Jeffery W. Kelly, Matthew W. Buczynski, Hagit Sason, Samuel Andrew Hires, Elena Molokanova, David G. Stouffer, Yuqiang Wang, Stuart A. Lipton, Gary Tong, Maria Talantova, Tomohiro Nakamura

Synaptic loss is the cardinal feature linking neuropathology to cognitive decline in Alzheimer’s disease (AD). However, the mechanism of synaptic damage remains incompletely understood. Here, using FRET-based glutamate sensor imaging, we show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a085ea362c8fc9ee8c5b6c9238fd8a18
https://europepmc.org/articles/PMC3704025/