The Effect of Difluoromethylornithine on Decreasing Prostate Size and Polyamines in Men: Results of a Year-Long Phase IIb Randomized Placebo-Controlled Chemoprevention Trial

Autor: Hoda Anton-Culver, Argyrios Ziogas, Christine E. McLaren, Ray Nagle, Eugene W. Gerner, Ronald Lieberman, Sharon Fujikawa-Brooks, Hagit F. Yerushalmi, Anne R. Simoneau, Frank L. Meyskens, Thomas E. Ahlering

Publikováno v: Simoneau, Anne R; Gerner, Eugene W; Nagle, Ray; Ziogas, Argyrios; Fujikawa-Brooks, Sharon; Yerushalmi, Hagit; et al.(2008). The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17(2), 292-299. doi: 10.1158/1055-9965.EPI-07-0658. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5qp5x7kk

Background: Prostate cancer is a major health issue, and prevention of prostate cancer and/or its progression will yield benefits for men. Difluoromethylornithine (DFMO) is an antiproliferative agent, inhibiting ornithine decarboxylase, the first enz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92942eed9ed251fcb06bcdb54b91a0c
https://doi.org/10.1158/1055-9965.epi-07-0658

Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival

Autor: Argyrios Ziogas, Hoda Anton-Culver, Natalia A. Ignatenko, Jason A. Zell, David G. Besselsen, Hagit F. Yerushalmi, Eugene W. Gerner

Publikováno v: Zell, Jason A; Ignatenko, Natalia A; Yerushalmi, Hagit F; Ziogas, Argyrios; Besselsen, David G; Gerner, Eugene W; et al.(2007). Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival. International Journal of Cancer, 120(3), 459-468. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2gj8z0zw

Elevated polyamine and nitric oxide levels (both derived from arginine) promote tumorigenesis, whereas non-steroidal anti-inflammatory drugs (NSAIDs) inhibit colorectal cancer (CRC) incidence in experimental and epidemiologic studies. We investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81461e5cd83ddea9629aba9773551960
http://www.escholarship.org/uc/item/2gj8z0zw

Role of polyamines in arginine-dependent colon carcinogenesis in Apc(Min) (/+) mice

Autor: David E. Stringer, Jose Guillen, Natalia A. Ignatenko, Karen A. Blohm-Mangone, Jose L. Padilla-Torres, Hagit F. Yerushalmi, Claire M. Payne, Eugene W. Gerner, Hana Holubec, David G. Besselsen

Publikováno v: Molecular carcinogenesis. 45(10)

We evaluated the role of polyamines in arginine-dependent intestinal tumorigenesis in ApcMin/+ mice. Arginine is a substrate for ornithine synthesis and thus can influence polyamine production. Supplementing the diet with arginine increased intestina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885753ba85039f10ba725bf0c8f95079
https://pubmed.ncbi.nlm.nih.gov/16705737

Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene

Autor: Kimberly E. Fultz, Maria Elena Martinez, Yongjun Guo, David S. Alberts, Hagit F. Yerushalmi, Janine G. Einspahr, David Boorman, Ning Qu, Eugene W. Gerner, Naveen Babbar, Thomas G. O'Brien

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 100(13)

Most sporadic colon adenomas acquire mutations in the adenomatous polyposis coli gene ( APC ) and show defects in APC -dependent signaling. APC influences the expression of several genes, including the c- myc oncogene and its antagonist Mad1 . Ornith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a6f1a1495821666f713ec02b5ec96b
https://pubmed.ncbi.nlm.nih.gov/12810952