Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Hagit Eldar-Finkelman"'
Autor:
Dorit Farfara, Meital Sooliman, Limor Avrahami, Tabitha Grace Royal, Shoshik Amram, Lea Rozenstein-Tsalkovich, Dorit Trudler, Shani Blanga-Kanfi, Hagit Eldar-Finkelman, Jens Pahnke, Hanna Rosenmann, Dan Frenkel
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Background Alzheimer’s disease (AD) is the leading cause of dementia in the world. The pathology of AD is affiliated with the elevation of both tau (τ) and β-amyloid (Aβ) pathologies. Yet, the direct link between natural τ expression o
Externí odkaz:
https://doaj.org/article/36f940c1cd774042b9dbd3ca9047e489
Autor:
Amnon Wittenstein, Michal Caspi, Ido Rippin, Orna Elroy-Stein, Hagit Eldar-Finkelman, Sven Thoms, Rina Rosin-Arbesfeld
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002355 (2023)
The introduction of premature termination codons (PTCs), as a result of splicing defects, insertions, deletions, or point mutations (also termed nonsense mutations), lead to numerous genetic diseases, ranging from rare neuro-metabolic disorders to re
Externí odkaz:
https://doaj.org/article/326ee8ebb9fd4674935f832a707e601c
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Glycogen synthase kinase-3 (GSK-3) is a highly conserved serine/threonine protein kinase that plays a central role in a wide variety of cellular processes, cognition and behaviour. In a previous study we showed that its α and β isozymes are highly
Externí odkaz:
https://doaj.org/article/3b014bb0a18743af95c2b8b70997e9ae
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2022)
The protein kinase, GSK-3, participates in diverse biological processes and is now recognized a promising drug discovery target in treating multiple pathological conditions. Over the last decade, a range of newly developed GSK-3 inhibitors of diverse
Externí odkaz:
https://doaj.org/article/c86fe7868f0b41eabe4de6be5ca39431
Autor:
Ido Rippin, Katherina Bonder, Shirley Joseph, Ammar Sarsor, Lilach Vaks, Hagit Eldar-Finkelman
Publikováno v:
Neurobiology of Disease, Vol 154, Iss , Pp 105336- (2021)
In Huntington's disease (HD), the mutant huntingtin (mHtt) accumulates as toxic aggregates in the striatum tissue, with deleterious effects on motor-coordination and cognitive functions. Reducing the levels of mHtt is therefore a promising therapeuti
Externí odkaz:
https://doaj.org/article/046c34e9ec654364a9ccf8bd0fb54142
Publikováno v:
Cells, Vol 11, Iss 10, p 1618 (2022)
Over the last decade, there has been continuous progress in our understanding of the biology of the protein kinase GSK-3 [...]
Externí odkaz:
https://doaj.org/article/f2c894619e724a4a89f220efaa992334
Autor:
Ido Rippin, Hagit Eldar-Finkelman
Publikováno v:
Cells, Vol 10, Iss 2, p 262 (2021)
Neurodegenerative disorders are spreading worldwide and are one of the greatest threats to public health. There is currently no adequate therapy for these disorders, and therefore there is an urgent need to accelerate the discovery and development of
Externí odkaz:
https://doaj.org/article/5326eced31fb425a9da176ff501cd854
Autor:
Ido Rippin, Netaly Khazanov, Shirley Ben Joseph, Tania Kudinov, Eva Berent, Sara Melisa Arciniegas Ruiz, Daniele Marciano, Laura Levy, Arie Gruzman, Hanoch Senderowitz, Hagit Eldar-Finkelman
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8709 (2020)
The serine/threonine kinase, GSK-3, is a promising drug discovery target for treating multiple pathological disorders. Most GSK-3 inhibitors that were developed function as ATP competitive inhibitors, with typical limitations in specificity, safety a
Externí odkaz:
https://doaj.org/article/ff762e800dab45ae811f661ea1aa2c29
Autor:
Richard L. Watson, Aaron C. Spalding, Steven P. Zielske, Meredith Morgan, Alex C. Kim, Guido T. Bommer, Hagit Eldar-Finkelman, Thomas Giordano, Eric R. Fearon, Gary D. Hammer, Theodore S. Lawrence, Edgar Ben-Josef
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 5, Pp 357-365 (2010)
BACKGROUND: Knowledge of factors and mechanisms contributing to the inherent radioresistance of pancreatic cancer may improve cancer treatment. Irradiation inhibits glycogen synthase kinase 3β (GSK3β) by phosphorylation at serine 9. In turn, releas
Externí odkaz:
https://doaj.org/article/0f0e827a05184e858ae9e9f30ed296b7
Autor:
Nadav Elkoshi, Shivang Parikh, Hagar Malcov-Brog, Roma Parikh, Paulee Manich, Francesca Netti, Avishai Maliah, Hana Elkoshi, Majd Haj, Ido Rippin, Jacob Frand, Tomer Perluk, Rivi Haiat-Factor, Tamar Golan, Neta Regev-Rudzki, Edo Kiper, Ronen Brenner, Pinchas Gonen, Iris Dror, Hagai Levi, Ofir Hameiri, Mazal Cohen-Gulkar, Hagit Eldar-Finkelman, Gil Ast, Eran Nizri, Yael Ziv, Rani Elkon, Mehdi Khaled, Yuval Ebenstein, Yosef Shiloh, Carmit Levy
Publikováno v:
Journal of Investigative Dermatology.