Zobrazeno 1 - 10
of 2 344
pro vyhledávání: '"Hagen S"'
Farnesyltransferase-inhibitors exert in vitro immunosuppressive capacity by inhibiting human B-cells
Autor:
Shilei Xu, Sebastian Dolff, Nils Mülling, Hagen S. Bachmann, Yang Dai, Monika Lindemann, Ming Sun, Oliver Witzke, Andreas Kribben, Benjamin Wilde
Publikováno v:
Frontiers in Transplantation, Vol 2 (2023)
ObjectivesFarnesyltransferase inhibitors (FTI), which inhibit the prenylation of Ras GTPases, were developed as anti-cancer drugs. As additional target proteins for prenylation were identified in the past, it is likely that FTI have potential value f
Externí odkaz:
https://doaj.org/article/4f21b1f33ef84b54905aebb329722c2d
Autor:
Dominik Jung, Hagen S. Bachmann
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114915- (2023)
Prenyltransferases (PTases) are known to play a role in embryonic development, normal tissue homeostasis and cancer by posttranslationally modifying proteins involved in these processes. They are being discussed as potential drug targets in an increa
Externí odkaz:
https://doaj.org/article/402d849a4e7146408881ebd69d6703b2
Autor:
Reeves, J. N., Braito, V., Luminari, A., Porquet, D., Laurenti, M., Matzeu, G., Lobban, A., Hagen, S.
PG 1448+273 is a luminous, nearby ($z=0.0645$), narrow line Seyfert 1 galaxy, which likely accretes close to the Eddington limit. Previous X-ray observations of PG 1448 with XMM-Newton in 2017 and NuSTAR in 2022 revealed the presence of an ultra fast
Externí odkaz:
http://arxiv.org/abs/2408.15095
Autor:
Arndt Büssing, Alexander Lindeberg, Beate Stock-Schröer, David Martin, Christian Scheffer, Hagen S. Bachmann
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2022)
Introduction: During the first lockdown of the COVID-19 pandemic, several medical students volunteered as assistants in hospitals, public health departments, and other healthcare services to support and substitute permanent staff. The underlying moti
Externí odkaz:
https://doaj.org/article/055c6e512d594a7fb60663ac9b7b5881
Autor:
Stefanie Klenke, Neval Akdeli, Patrick Stelmach, Lukas Heukamp, Johannes H. Schulte, Hagen S. Bachmann
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 has become a treatmen
Externí odkaz:
https://doaj.org/article/a3fc921c2113459caafeb6ba760322e7
Autor:
Veresvarska, M., Scaringi, S., Hagen, S., De Martino, D., Done, C., Ilkiewicz, K., Knigge, C., Littlefield, C.
The classical nova CP Puppis has been observed to have particularly puzzling and peculiar properties. In particular, this classical nova displays occasional bursts in its long-term ASAS-SN light curve. Here we report on 5 sectors of TESS data display
Externí odkaz:
http://arxiv.org/abs/2402.14068
Autor:
Sonali Pechlivanis, Susanne Moebus, Nils Lehmann, Raimund Erbel, Amir A Mahabadi, Per Hoffmann, Karl-Heinz Jöckel, Markus M Nöthen, Hagen S Bachmann, Heinz Nixdorf Recall Study Investigative Group
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232735 (2020)
BACKGROUND:Atherosclerosis is the primary cause of coronary artery disease (CAD). Several observational studies have examined the association of traditional CAD risk factors with the progression of coronary artery calcification (CAC). In our study we
Externí odkaz:
https://doaj.org/article/b3c758b4d07344198c9f6d8ab45348c6
Autor:
Kemal Mese, Oskar Bunz, Wolfram Volkwein, Sahithya P. B. Vemulapalli, Wenli Zhang, Sebastian Schellhorn, Kristin Heenemann, Antje Rueckner, Andreas Sing, Thomas W. Vahlenkamp, Anna-Lena Severing, Jian Gao, Malik Aydin, Dominik Jung, Hagen S. Bachmann, Kurt S. Zänker, Ulrich Busch, Armin Baiker, Christian Griesinger, Anja Ehrhardt
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10075 (2021)
Previous studies reported on the broad-spectrum antiviral function of heparin. Here we investigated the antiviral function of magnesium-modified heparin and found that modified heparin displayed a significantly enhanced antiviral function against hum
Externí odkaz:
https://doaj.org/article/1fc12fc74423454e851f3e7bb818137f