Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hagen R. Witzel"'
Autor:
Tiemo S. Gerber, Benjamin Goeppert, Anne Hausen, Hagen R. Witzel, Fabian Bartsch, Mario Schindeldecker, Lisa-Katharina Gröger, Dirk A. Ridder, Oscar Cahyadi, Irene Esposito, Matthias M. Gaida, Peter Schirmacher, Peter R. Galle, Hauke Lang, Wilfried Roth, Beate K. Straub
Publikováno v:
Cancers, Vol 14, Iss 13, p 3091 (2022)
Carcinomas of the pancreatobiliary system confer an especially unfavorable prognosis. The differential diagnosis of intrahepatic cholangiocarcinoma (iCCA) and its subtypes versus liver metastasis of ductal adenocarcinoma of the pancreas (PDAC) is cli
Externí odkaz:
https://doaj.org/article/505f756fee204a36a57ad04e4f01d573
Autor:
Philipp Mayer, Anne Kraft, Hagen R. Witzel, Nicole Marnet, Nina Hörner, Wilfried Roth, Stefan Heinrich, Thilo Hackert, Frank Bergmann, Hans-Ulrich Kauczor, Miriam Klauss, Matthias M. Gaida
Publikováno v:
Cancers, Vol 13, Iss 1, p 89 (2020)
Hypoxia is a hallmark of pancreatic cancer (PDAC) due to its compact and extensive fibrotic tumor stroma. Hypoxia contributes to high lethality of this disease, by inducing a more malignant phenotype and resistance to radiation and chemotherapy. Thus
Externí odkaz:
https://doaj.org/article/249a853748e94181a0409fc998e30c8e
Publikováno v:
Stem Cell Reports
Summary During development, cells respond rapidly to intra- and intercellular signals, which induce signaling cascades regulating the activity of transcription factors at the transcriptional and/or post-translational level. The transcription factor I
Publikováno v:
Scientific Reports
After initial formation, the heart tube grows by addition of second heart field progenitor cells to its poles. The transcription factor Isl1 is expressed in the entire second heart field in mouse, and Isl1-deficient mouse embryos show defects in arte
Autor:
Thomas Braun, Chong Pyo Choe, Benno Jungblut, Gergana Dobreva, Hagen R. Witzel, J. Gage Crump
Publikováno v:
Developmental Cell. 23(1):58-70
Summary Morphogenesis of the heart requires tight control of cardiac progenitor cell specification, expansion, and differentiation. Retinoic acid (RA) signaling restricts expansion of the second heart field (SHF), serving as an important morphogen in
Autor:
Gergana Dobreva, Sirisha Cheedipudi, Petros Kolovos, Thomas Braun, Mario Looso, Frank Grosveld, Karl-Ludwig Laugwitz, Sylvia M. Evans, Luca Caputo, Athina Mylona, Eric Soler, Hagen R. Witzel, Wilfred F. J. van IJcken
Publikováno v:
EUR Research Portal
Cell Stem Cell, 17(3), 287-299. Cell Press
Cell Stem Cell, 17(3), 287-299. Cell Press
Cardiac stem/progenitor cells hold great potential for regenerative therapies however the mechanisms regulating their expansion and differentiation remain insufficiently defined. Here we show that the multi-adaptor protein Ldb1 is a central regulator