Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Hagen Klett"'
Autor:
Christina Hartwig, Jan Müller, Hagen Klett, Dina Kouhestani, Anke Mittelstädt, Anna Anthuber, Paul David, Maximilian Brunner, Anne Jacobsen, Karolina Glanz, Izabela Swierzy, Lotta Roßdeutsch, Bettina Klösch, Robert Grützmann, Timo Wittenberger, Kai Sohn, Georg F. Weber
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-7 (2024)
Abstract Background Current diagnostics for the detection of pancreato-biliary cancers (PBCs) need to be optimized. We therefore propose that methylated cell-free DNA (cfDNA) derived from non-invasive liquid biopsies serves as a novel biomarker with
Externí odkaz:
https://doaj.org/article/9a79fe14ad154077ba918ec5b2bf60e4
Autor:
Christian K. Hirt, Tijmen H. Booij, Linda Grob, Patrik Simmler, Nora C. Toussaint, David Keller, Doreen Taube, Vanessa Ludwig, Alexander Goryachkin, Chantal Pauli, Daniela Lenggenhager, Daniel J. Stekhoven, Christian U. Stirnimann, Katharina Endhardt, Femke Ringnalda, Lukas Villiger, Alexander Siebenhüner, Sofia Karkampouna, Marta De Menna, Janette Beshay, Hagen Klett, Marianna Kruithof-de Julio, Julia Schüler, Gerald Schwank
Publikováno v:
Cell Genomics, Vol 2, Iss 2, Pp 100095- (2022)
Summary: Pancreatic cancer (PDAC) is a highly aggressive malignancy for which the identification of novel therapies is urgently needed. Here, we establish a human PDAC organoid biobank from 31 genetically distinct lines, covering a representative ran
Externí odkaz:
https://doaj.org/article/528029a5e0b440e9b617944420259540
Autor:
Hagen Klett, Yesilda Balavarca, Reka Toth, Biljana Gigic, Nina Habermann, Dominique Scherer, Petra Schrotz-King, Alexis Ulrich, Peter Schirmacher, Esther Herpel, Hermann Brenner, Cornelia M. Ulrich, Karin B. Michels, Hauke Busch, Melanie Boerries
Publikováno v:
Epigenetics, Vol 13, Iss 4, Pp 386-397 (2018)
DNA methylation is recognized as one of several epigenetic regulators of gene expression and as potential driver of carcinogenesis through gene-silencing of tumor suppressors and activation of oncogenes. However, abnormal methylation, even of promote
Externí odkaz:
https://doaj.org/article/ca5222ded48e4e4da6ecdf8d76412d05
Autor:
Milena N. Leseva, Richard J. Grand, Hagen Klett, Melanie Boerries, Hauke Busch, Alexandra M. Binder, Karin B. Michels
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract In humans the expression of lactase changes during post-natal development, leading to phenotypes known as lactase persistence and non-persistence. Polymorphisms within the lactase gene (LCT) enhancer, in particular the −13910C > T, but als
Externí odkaz:
https://doaj.org/article/2de50f8af6c74389afa70cd5b6b411af
Autor:
Hagen Klett, Hannah Fuellgraf, Ella Levit-Zerdoun, Saskia Hussung, Silke Kowar, Simon Küsters, Peter Bronsert, Martin Werner, Uwe Wittel, Ralph Fritsch, Hauke Busch, Melanie Boerries
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Late diagnosis and systemic dissemination essentially contribute to the invariably poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Therefore, the development of diagnostic biomarkers for PDAC are urgently needed to improve patient stratifi
Externí odkaz:
https://doaj.org/article/7676b7b973824581a3fe81105ce3ebeb
Autor:
Julia Schueler, Cordula Tschuch, Kerstin Klingner, Daniel Bug, Anne-Lise Peille, Leanne de Koning, Eva Oswald, Hagen Klett, Wolfgang Sommergruber
Publikováno v:
Cells, Vol 8, Iss 7, p 740 (2019)
In up to 30% of non-small cell lung cancer (NSCLC) patients, the oncogenic driver of tumor growth is a constitutively activated epidermal growth factor receptor (EGFR). Although these patients gain great benefit from treatment with EGFR tyrosine kina
Externí odkaz:
https://doaj.org/article/60af5e27fd674a39be230ddc5b6944c8
Autor:
Hagen Klett, Lonny Jürgensen, Patrick Most, Martin Busch, Fabian Günther, Gergana Dobreva, Florian Leuschner, David Hassel, Hauke Busch, Melanie Boerries
Publikováno v:
Biomolecules, Vol 9, Iss 1, p 11 (2018)
Heart diseases are the leading cause of death for the vast majority of people around the world, which is often due to the limited capability of human cardiac regeneration. In contrast, zebrafish have the capacity to fully regenerate their hearts afte
Externí odkaz:
https://doaj.org/article/748016a256a94432a5f8e55313f74a12
Autor:
Umberto Perron, Elena Grassi, Aikaterini Chatzipli, Marco Viviani, Emre Karakoc, Lucia Trastulla, Claudio Isella, Eugenia R Zanella, Hagen Klett, Ivan Molineris, Julia Schueler, Manel Esteller, Enzo Medico, Nathalie Conte, Ultan McDermott, Livio Trusolino, Andrea Bertotti, Francesco Iorio
Patient-derived xenografts (PDXs) are tumour fragments engrafted into mice for preclinical studies. PDXs offer clear advantages over simplerin vitrocancer models - such as cancer cell lines (CCLs) and organoids - in terms of structural complexity, he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7fd70cd9795d3f3f13ad5a535fef2c6
https://doi.org/10.1101/2023.01.24.525314
https://doi.org/10.1101/2023.01.24.525314
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 37(1)
Folate plays an important role in the modulation of one-carbon metabolism and DNA methylation through a complex biosynthesis pathway. Folate deficiency during pregnancy has been associated with an increased risk for birth defects. This study investig
Autor:
Martin Busch, Thien-Kim Bui, Lukas Adrian, Fabian Guenther, Mandy Rettel, Frank Stein, Jan Haas, Hagen Klett, Melanie Boerries, Benjamin Meder, Christoph Dieterich, Hugo A Katus, Patrick Most
Publikováno v:
Circulation Research. 131
Background and Hypothesis: Expression of the cardiomyocyte (CM) protein S100A1, which improves contractile performance of the heart, sharply increases during postnatal myocardial maturation but declines rapidly in failing hearts. We therefore hypothe