Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia

Autor: Smits, Willem K., Vermeulen, Carlo, Hagelaar, Rico, Kimura, Shunsuke, Vroegindeweij, Eric M., Buijs-Gladdines, Jessica G.C.A.M., van de Geer, Ellen, Verstegen, Marjon J.A.M., Splinter, Erik, van Reijmersdal, Simon V., Buijs, Arjan, Galjart, Niels, van Eyndhoven, Winfried, van Min, Max, Kuiper, Roland, Kemmeren, Patrick, Mullighan, Charles G., de Laat, Wouter, Meijerink, Jules P.P.

Publikováno v: In Cell Reports 25 April 2023 42(4)

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T-cell lymphoblastic lymphoma compared with T-cell acute lymphoblastic leukemia: similar subtypes and different fusions

Autor: Kroeze, Emma, Kleisman, Michelle M., Hagelaar, Rico, Bladergroen, Reno S., Kester, Lennart A., Scheijde-Vermeulen, Marijn A., van Dijk, Freerk, Meijerink, Jules P. P., Kuiper, Roland P., Loeffen, Jan L. C.

Publikováno v: In Blood Neoplasia September 2024 1(3)

STAT5 does not drive steroid resistance in T-cell acute lymphoblastic leukemia despite the activation of BCL2 and BCLXL following glucocorticoid treatment

Autor: van der Zwet, Jordy C. G., Cordo, Valentina, Buijs-Gladdines, Jessica G. C. A. M., Hagelaar, Rico, Smits, Willem K., Vroegindeweij, Eric, Graus, Laura T. M., Poort, Vera M., Nulle, Marloes, Pieters, Rob, Meijerink, Jules P. P.

Publikováno v: van der Zwet, J C G, Cordo, V, Buijs-Gladdines, J G C A M, Hagelaar, R, Smits, W K, Vroegindeweij, E, Graus, L T M, Poort, V M, Nulle, M, Pieters, R & Meijerink, J P P 2023, ' STAT5 does not drive steroid resistance in T-cell acute lymphoblastic leukemia despite the activation of BCL2 and BCLXL following glucocorticoid treatment ', Haematologica, vol. 108, no. 3, pp. 732-746 . https://doi.org/10.3324/haematol.2021.280405
Haematologica, 108(3), 732-746. Ferrata Storti Foundation

Physiological and pathogenic interleukin-7-receptor (IL7R)-induced signaling provokes glucocorticoid resistance in a subset of patients with pediatric T-cell acute lymphoblastic leukemia (T-ALL). Activation of downstream STAT5 has been suggested to c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cdf20d20fc1dbadc12cb3ebfc701a5a9
https://research.vumc.nl/en/publications/51885ecf-0a40-48a2-b234-4a13b67448e5

Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia.

Autor: Schneider, Pauline, Crump, Nicholas T., Arentsen-Peters, Susan T.C.J.M., Smith, Alastair L., Hagelaar, Rico, Adriaanse, Fabienne R.S., Bos, Romy S., de Jong, Anja, Nierkens, Stefan, Koopmans, Bianca, Milne, Thomas A., Pieters, Rob, Stam, Ronald W.

Publikováno v: Experimental Hematology & Oncology; 9/22/2023, Vol. 12 Issue 1, p1-13, 13p