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Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies.

Autor: Easton A; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Jensen ML; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, Hørsholm DK 2970, Denmark., Wang C; Roche Pharma Research and Early Development, Neuroscience and Rare Disease Discovery and Translational Area, Roche Innovation Center Basel, 4070 Basel, Switzerland., Hagedorn PH; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, Hørsholm DK 2970, Denmark., Li Y; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Weed M; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Meredith JE; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Guss V; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Jones K; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Gill M; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Krause C; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Brown JM; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Hunihan L; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Natale J; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Fernandes A; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Lu Y; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Polino J; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Bookbinder M; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Cadelina G; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Benitex Y; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Sane R; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Morrison J; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Drexler D; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Mercer SE; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Bon C; Roche Pharma Research and Early Development, Neuroscience and Rare Disease Discovery and Translational Area, Roche Innovation Center Basel, 4070 Basel, Switzerland., Pandya NJ; Roche Pharma Research and Early Development, Neuroscience and Rare Disease Discovery and Translational Area, Roche Innovation Center Basel, 4070 Basel, Switzerland., Jagasia R; Roche Pharma Research and Early Development, Neuroscience and Rare Disease Discovery and Translational Area, Roche Innovation Center Basel, 4070 Basel, Switzerland., Ou Yang TH; Roche Pharma Research and Early Development, pREDi Data Science, Roche Innovation Center New York, Little Falls, NJ 07424, USA., Distler T; Roche Pharma Research and Early Development, Neuroscience and Rare Disease Discovery and Translational Area, Roche Innovation Center Basel, 4070 Basel, Switzerland., Grüninger F; Roche Pharma Research and Early Development, Neuroscience and Rare Disease Discovery and Translational Area, Roche Innovation Center Basel, 4070 Basel, Switzerland., Meldgaard M; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, Hørsholm DK 2970, Denmark., Terrigno M; Roche Pharma Research and Early Development, Neuroscience and Rare Disease Discovery and Translational Area, Roche Innovation Center Basel, 4070 Basel, Switzerland., Macor JE; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Albright CF; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Loy J; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Hoeg AM; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, Hørsholm DK 2970, Denmark., Olson RE; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA., Cacace AM; Bristol Myers Squibb Research and Development, Cambridge, MA 02142, USA.

Publikováno v: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2022 Aug 04; Vol. 29, pp. 625-642. Date of Electronic Publication: 2022 Aug 04 (Print Publication: 2022).

Characterization of Escherichia coli RNase H Discrimination of DNA Phosphorothioate Stereoisomers.

Autor: Kiełpiński ŁJ; Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, Hørsholm, Denmark., Funder ED; Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, Hørsholm, Denmark., Schmidt S; Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, Hørsholm, Denmark., Hagedorn PH; Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, Hørsholm, Denmark.

Publikováno v: Nucleic acid therapeutics [Nucleic Acid Ther] 2021 Dec; Vol. 31 (6), pp. 383-391. Date of Electronic Publication: 2021 Oct 07.

Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides.

Autor: Anderson BR; Bristol-Myers Squibb Research and Development, 3551 Lawrenceville Rd, Princeton, NJ 08540, USA. Electronic address: brian.anderson@bms.com., Jensen ML; RNA Therapeutics Research, Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, Hørsholm, Denmark., Hagedorn PH; RNA Therapeutics Research, Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, Hørsholm, Denmark., Little SC; Bristol-Myers Squibb Research and Development, 3551 Lawrenceville Rd, Princeton, NJ 08540, USA., Olson RE; Bristol-Myers Squibb Research and Development, 3551 Lawrenceville Rd, Princeton, NJ 08540, USA., Ammar R; Bristol-Myers Squibb Research and Development, 3551 Lawrenceville Rd, Princeton, NJ 08540, USA., Kienzle B; Bristol-Myers Squibb Research and Development, 3551 Lawrenceville Rd, Princeton, NJ 08540, USA., Thompson J; Bristol-Myers Squibb Research and Development, 3551 Lawrenceville Rd, Princeton, NJ 08540, USA., McDonald I; Bristol-Myers Squibb Research and Development, 3551 Lawrenceville Rd, Princeton, NJ 08540, USA., Mercer S; Bristol-Myers Squibb Research and Development, 3551 Lawrenceville Rd, Princeton, NJ 08540, USA., Vikesaa J; RNA Therapeutics Research, Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, Hørsholm, Denmark., Nordbo B; RNA Therapeutics Research, Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, Hørsholm, Denmark., Iben L; Bristol-Myers Squibb Research and Development, 3551 Lawrenceville Rd, Princeton, NJ 08540, USA., Cao Y; Bristol-Myers Squibb Research and Development, 3551 Lawrenceville Rd, Princeton, NJ 08540, USA., Natale J; Bristol-Myers Squibb Research and Development, 3551 Lawrenceville Rd, Princeton, NJ 08540, USA., Dalton-Kay G; Bristol-Myers Squibb Research and Development, 3551 Lawrenceville Rd, Princeton, NJ 08540, USA., Cacace A; Bristol-Myers Squibb Research and Development, 3551 Lawrenceville Rd, Princeton, NJ 08540, USA., Hansen BR; RNA Therapeutics Research, Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, Hørsholm, Denmark., Hedtjärn M; RNA Therapeutics Research, Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, Hørsholm, Denmark., Koch T; RNA Therapeutics Research, Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, Hørsholm, Denmark., Bristow LJ; Bristol-Myers Squibb Research and Development, 3551 Lawrenceville Rd, Princeton, NJ 08540, USA.

Publikováno v: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2020 Mar 06; Vol. 19, pp. 1290-1298. Date of Electronic Publication: 2020 Jan 21.