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Delamanid Added to an Optimized Background Regimen in Children with Multidrug-Resistant Tuberculosis: Results of a Phase I/II Clinical Trial.

Autor: Garcia-Prats AJ; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, South Africa., Frias M; De La Salle Health Science Center, Cavite, Philippines., van der Laan L; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, South Africa., De Leon A; Lung Center of the Philippines, Quezon City, Philippines., Gler MT; De La Salle Health Science Center, Cavite, Philippines., Schaaf HS; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, South Africa., Hesseling AC; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, South Africa., Malikaarjun S; Otsuka Pharmaceutical Development & Commercialization, Rockville, Maryland, USA., Hafkin J; Otsuka Pharmaceutical Development & Commercialization, Rockville, Maryland, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2022 May 17; Vol. 66 (5), pp. e0214421. Date of Electronic Publication: 2022 Apr 11.

Population Pharmacokinetic and Concentration-QTc Analysis of Delamanid in Pediatric Participants with Multidrug-Resistant Tuberculosis.

Autor: Sasaki T; Otsuka Pharmaceutical Co., Ltd., Osaka, Japan., Svensson EM; Department of Pharmacy, Uppsala Universitygrid.8993.b, Uppsala, Sweden.; Department of Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands., Wang X; Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, Maryland, USA., Wang Y; Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, Maryland, USA., Hafkin J; Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, Maryland, USA., Karlsson MO; Department of Pharmacy, Uppsala Universitygrid.8993.b, Uppsala, Sweden., Mallikaarjun S; Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, Maryland, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2022 Feb 15; Vol. 66 (2), pp. e0160821. Date of Electronic Publication: 2021 Nov 29.

Cumulative Fraction of Response for Once- and Twice-Daily Delamanid in Patients with Pulmonary Multidrug-Resistant Tuberculosis.

Autor: Mallikaarjun S; Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, Maryland, USA., Chapagain ML; Baylor Research Institute, Dallas, Texas, USA.; Praedicare, Dallas, Texas, USA., Sasaki T; Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan., Hariguchi N; Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan., Deshpande D; Baylor Research Institute, Dallas, Texas, USA., Srivastava S; Baylor Research Institute, Dallas, Texas, USA.; University of Texas Health Science Center, Tyler, Texas, USA., Berg A; Critical Path Institute, Tucson, Arizona, USA., Hirota K; Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan., Inoue Y; Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan., Matsumoto M; Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan., Hafkin J; Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, Maryland, USA., Geiter L; Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, Maryland, USA., Wang X; Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, Maryland, USA., Gumbo T; Baylor Research Institute, Dallas, Texas, USA.; Praedicare, Dallas, Texas, USA., Liu Y; Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, Maryland, USA yongge.liu@otsuka-us.com.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Dec 16; Vol. 65 (1). Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2020).

TUPDB0204: Very early initiation of combination antiviral therapy results in normal levels of markers of immune activation

Autor: Kyrychenko, T., Dubynska, G., Koval, T., Kaidashev, I., Korshenko, V., Rono, K., Kibuuka, H., Maganga, L., Kosgei, J., Sekiziyivu, A., Sanga, E., Ngetich, E., Bolen Valenzuela, A., Michael, N., Robb, M., Markowitz, M., Evering, T., Figueroa, A., Rodriguez, K., La Mar, M., Garmon, D., Sahi, V., Mohri, H., Asher, A., Santos, G.-M., Dokubo, E.K., Martin, J., Deeks, S., Tobler, L., Busch, M., Hunt, P., Page, K., Weber, R., Smith, C., Mannheimer, S., Wang, L., Tieu, H.V., del Rio, C., Buchbinder, S., Wilton, L., Glick, S., Cummings, V., Mayer, K.H., Hutchinson, A., Sansom, S., Farnham, P., Davis, R., Dzoro, S., Moyo, S., Gaseitsiwe, S., Musonda, R., Novitsky, V., Essex, M., Ouma, K., Basavaraju, S., Okonji, J., Williamson, J., Mills, L., Zeh, C., Vallabhaneni, S., Chandy, S., Heylen, E., Ekstrand, M.L., Manasa, J., McGrath, N., Lessells, R., Skingsley, A., Newell, M.-L., de Oliveira, T., Rawizza, H., Chaplin, B., Meloni, S., Okonkwo, P., Kanki, P., Gale, H., Gitterman, S., Gordin, F., Benator, D., Kan, V., Meya, D., Rajasingham, R., Rolfes, M., Birkenkamp, K., Boulware, D., Bulterys, P., Le, T., Quang, V.M., Nelson, K., Lloyd-Smith, J., Luetkemeyer, A.F., Rosenkranz, S.L., Lu, D., Lizak, P.S., Ive, P., Swindells, S., Benson, C.A., Grinsztejn, B., Sanne, I.M., Havlir, D.V., Aweeka, F., Sterling, T., Benson, C., Shang, N., Miro, J., Chaisson, R., Lucchetti, A., Sanchez, J., Scott, N., Villarino, E., McIlleron, H., Martinson, N., Denti, P., Mashabela, F., Hunt, J., Shembe, S., Hull, J., Haas, D.W., Msandiwa, R., Cohn, S., Dooley, K.E., Everitt, D., Winter, H., Egizi, E., Murray, S., Diacon, A., Dawson, R., Hutchings, J., Van Niekerk, C., Becker, P., Hafkin, J., Modongo, C., Newcomb, C., Lowenthal, E., MacGregor, R.R., Steenhoff, A., Friedman, H., Bisson, G., Fitzgerald, D., Jansen, P., Chipungu, C., Dindi, V., Fielder, J., Pfaff, C., Bygrave, H., Simons, S., Munyaradzi, D., Nyagadza, B., Metcalf, C., Ncube, K., Van Den Broucke, S., Mupfumi, L., Mason, P., Zinyowera, S., Mutetwa, R., Wallis, R.S., Diacon, A.H., Venter, A., Friedrich, S.O., Paige, D., Zhu, T., Silvia, A., Gobey, J., Ellery, C., Zhang, Y., Kadyszewski, E., Brust, J.C.M., Shah, N.S., van der Merwe, T.L., Bamber, S., Mngadi, A., Ning, Y., Heo, M., Moll, A.P., Loveday, M., Lalloo, U.G., Friedland, G.H., Gandhi, N.R., Hawkins, C., Christian, B., Ye, J., Nagu, T., Aris, E., Chalamilla, G., Spiegelman, D., Mugusi, F., Mehta, S., Fawzi, W., Lo Re, V., Tate, J., Kallan, M., Lim, J., Goetz, M., Klein, M., Rimland, D., Rodriguez-Barradas, M., Butt, A., Gibert, C., Brown, S., Kostman, J., Strom, B., Reddy, R., Justice, A., Localio, R., Amorosa, V., Umbleja, T., Johnson, V., Kang, M., Luetkemeyer, A., Bardin, M., Haas, D., Chung, R., Yesmin, S., Coughlin, K., Martinez, A., Adams, M.B., Alston-Smith, B., Tebas, P., Peters, M., Kahn, J., Xu, J., Kapogiannis, B., Rudy, B., Liu, N., Gonin, R., Wilson, C., Worrell, C., Squires, K., Kojic, E.M., Cespedes, M., Aberg, J., Allen, R., Grinsztein, B., Firnhaber, C., Webster-Cyriaque, J., Palefsky, J.M., Godfrey, C., Saah, A.J., Cu-Uvin, S., Rangaka, M.X., Boulle, A., Wilkinson, R.J., van Cutsem, G., Goemaere, E., Goliath, R., Titus, R., Mathee, S., Maartens, G., Shet, A., Holla, S., Raman, V., Dinakar, C., Ashok, M., Dufouil, C., Richert, L., Bruyand, M., Amieva, H., Dauchy, F.-A., Dartigues, J.-F., Neau, D., Dabis, F., Morlat, P., Bonnet, F., Chene, G., Nigo, M., Walker, A., Lucido, D., Shah, A., Skliut, M., Mildvan, D., Sahasrabuddhe, V., Castle, P., Follansbee, S., Borgonovo, S., LaMere, B., Tokugawa, D., Darragh, T., Boyle, S., Sadorra, M., Tang, S., Wentzensen, N., Mills, A., Podzamczer, D., Fätkenheuer, G., Leal, M., Than, S., Valluri, S.R., Craig, C., Vourvahis, M., Heera, J., Valdez, H., Brown, T., Rinehart, A., Portsmouth, S., Gallant, J., Koenig, E., Andrade-Villanueva, J., Chetchotisakd, P., Dejesus, E., Antunes, F., Arastéh, K., Moyle, G., Rizzardini, G., Fehr, J., Liu, Y.-P., Zhong, L., Callebaut, C., Ramanathan, S., Szwarcberg, J., Rhee, M., Cheng, A., Palella, F., Gazzard, B., Ruane, P., Shamblaw, D., Flamm, J., Fisher, M., van Lunzen, J., Ebrahimi, R., White, K., Guyer, B., Graham, H., Fralich, T., Elion, R., Molina, J.-M., Arribas-Lopez, J.-R., Cooper, D., Maggiolo, F., Wilkins, E., Conway, B., Margot, N., Raffi, F., Rachlis, A., Stellbrink, H.-J., Hardy, W.D., Torti, C., Orkin, C., Bloch, M., Pokrovsky, V., Almond, S., Margolis, D., Min, S., Karasi, J.-C., Musonera, F., Iranyumviye, K., Servais, J.-Y., Devaux, C., Binagwaho, A., Arendt, V., Shafer, R., Zolopa, A., Schmit, J.-C., Rimsky, L., Van Eygen, V., Vingerhoets, J., Thys, K., Aerssens, J., Stevens, M., Picchio, G., van Zyl, G., Claassen, M., Engelbrecht, S., Preiser, W., Wood, N., Travers, S., Charpentier, C., Landman, R., Laouénan, C., Joly, V., Hamet, G., Damond, F., Brun-Vézinet, F., Mentré, F., Descamps, D., Yeni, P., De Castro, N., Arnold, V., Veloso, V., Morgado, M., Pilotto, J.H., Brites, C., Madruga, J.V., Barcellos, N., Riegel Santos, B., Vorsatz, C., Grondin, C., Santini-Oliveira, M., Patey, O., Delaugerre, C., Chêne, G., Venuto, C., Mollan, K., Ma, Q., Daar, E., Sax, P., Fischl, M., Collier, A., Smith, K., Tierney, C., Morse, G., Acosta, E., Vardhanabhuti, S., Ribaudo, H., Severe, P., Lalloo, U., Kumarasamy, N., Taulo, F., Kabanda, J., Oneko, O., Sambarey, P., Chan, E., Hitti, J., McMahon, D., Gandhi, M., Greenblatt, R., Bacchetti, P., Jin, C., Cohen, M., Dehovitz, J., Anastos, K., Gange, S., Liu, C., Hanson, S., Aouizerat, B., Gervasoni, C., Baldelli, S., Cerea, M., Meraviglia, P., Landonio, S., Simioni, M., Gazzaniga, A., Galli, M., Clementi, E., Cattaneo, D., Hosseinipour, M., Eron, J., Chen, Y.Q., Ou, S.-S., Anderson, M., McCauley, M., Gamble, T., Hakim, J., Kumwenda, J., Pilotto, J., Godbole, S., Chariyalertsak, S., Santos, B., Mayer, K., Eshleman, S., Piwowar-Manning, E., Cottle, L., Makhema, J., Panchia, R., Sanne, I., Elharrar, V., Havlir, D., Cohen, M.S., Kanki, P.J., Chang, C., Jolayemi, T., Banigbe-Aluko, B., Rewari, B.B., Shaukat, M., Kabra, S., Srikantiah, P., Lundgren, J., Colombero, C., Rocco, C., Mecikovsky, D., Bologna, R., Aulicino, P., Sen, L., Mangano, A., Nielsen-Saines, K., Mirochnick, M., Kumwenda, N., Joao, E.C., Kreitchmann, R., Pinto, J., Parsons, T., Richardson, P., Taha, T., Mofenson, L., Sato, P., Kearney, B., Fowler, M.G., Hazra, R., Viani, R., Zheng, N., Alvero, C., O'Gara, E., Petzold, E., Heckman, B., Steimers, D., Song, I., Piscitelli, S., Wiznia, A., Cotton, M., Cassim, H., Pavía-Ruz, N., Ross, L., Ford, S., Givens, N., Cheng, K., Sievers, J., Tudor-Williams, G., Cahn, P., Chokephaibulkit, K., Fourie, J., Karatzios, C., Dincq, S., Kakuda, T.N., Nijs, S., Tambuyzer, L., Tomaka, F., Nachman, S., Teppler, H., Homony, B., Xu, X., Handelsman, E., Graham, B., Toye, M., Miruka, A., Achieng, R., Aoko, A., Tarus, J., Sigei, C., Yegon, P., Maswai, J., Sawe, F., Shaffer, D., Crawford, K., Kanjanavanit, S., Puthanakit, T., Kosalaraksa, P., Hansudewechakul, R., Ngampiyaskul, C., Pinyakorn, S., Luesomboon, W., Vonthanak, S., Ananworanich, J., Ruxrungtham, K., Miller, T.L., Wang, J., Jacobson, D.L., Takemoto, J.K., Sharma, T., Geffner, M.E., Libutti, D.E., Siminski, S., Dooley, L., Somarriba, G., Graham, P., Gerschenson, M., van Ramshorst, M., Struthers, H., McIntyre, J.A., Peters, R.P.H., Himes, S., Scheidweiler, K., Tassiopoulos, K., Kacanek, D., Rich, K., Huestis, M., O'Brien, M., Nardi, M.A., Montenont, E., Valdes, V., Hu, L., Merolla, M., Gettenberg, G., Bhardwaj, N., Berger, J.S., Kelesidis, T., Kendall, M., Yang, O., Currier, J., McComsey, G.A., Kitch, D., Sax, P.E., Jahed, N.C., Melbourne, K., Ha, B., Brown, T.T., Bloom, A., Fedarko, N., Daar, E.S., Schouten, J., Wit, F.W., Stolte, I.G., van der Valk, M., Geerlings, S.E., de Wolf, F., Prins, M., Reiss, P., Sypek, A., Morris, B., Losina, E., Paltiel, A.D., Seage, G., Walensky, R., Weinstein, M., Freedberg, K.

Publikováno v: Journal of the International AIDS Society

Background Toll-like receptors (TLRs) are transmembrane receptors that activate cells of the innate immune systems upon recognition of pathogen-associated molecular patterns. The TLR4 is an essential component of the innate immune response to various

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df134f05f40609b3ca3748f60a46f47
http://europepmc.org/articles/PMC3499900