Inducing Receptor Degradation as a Novel Approach to Target CC Chemokine Receptor 2 (CCR2).

Autor: Ortiz Zacarías, Natalia V.¹ (AUTHOR) jeremybroekhuis@outlook.com, Röth, Sascha² (AUTHOR) sascha.roth@astrazeneca.com, Broekhuis, Jeremy D.^1,3 (AUTHOR) d.van.der.es@lacdr.leidenuniv.nl, van der Es, Daan¹ (AUTHOR) l.h.heitman@lacdr.leidenuniv.nl, Moreau, Kevin² (AUTHOR) kevin.moreau@astrazeneca.com, Heitman, Laura H.^1,3 (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 16, p8984. 22p.

Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds.

Autor: Nabuurs RJ; Department of Radiology CS2, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands., Kapoerchan VV; Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands., Metaxas A; Radionucleotide Laboratory, Free University, Amsterdam, Netherlands., Hafith S; Department of Radiology CS2, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands., de Backer M; Department of Radiology CS2, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands., Welling MM; Department of Radiology CS2, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands., Jiskoot W; Division of Drug Delivery Technology, Leiden Academic Center for Drug Research, Leiden University, Leiden, Netherlands., van den Nieuwendijk AM; Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands., Windhorst AD; Radionucleotide Laboratory, Free University, Amsterdam, Netherlands., Overkleeft HS; Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands., van Buchem MA; Department of Radiology CS2, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands., Overhand M; Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands., van der Weerd L; Department of Radiology CS2, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands. Electronic address: l.van_der_weerd@lumc.nl.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2016 Dec 01; Vol. 24 (23), pp. 6139-6148. Date of Electronic Publication: 2016 May 18.

Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2.

Autor: Zweemer AJ; Division of Medicinal Chemistry, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands (A.J.M.Z., I.N., H.V., S.H., M.L.J.D., H.d.V., A.P.IJ., L.H.H.); Vertex Pharmaceuticals, Inc., San Diego, California (J.A., R.G., D.S., J.S.); and Division of Medicinal Chemistry, VU University Amsterdam, Amsterdam, The Netherlands (M.J.S.)., Nederpelt I, Vrieling H, Hafith S, Doornbos ML, de Vries H, Abt J, Gross R, Stamos D, Saunders J, Smit MJ, Ijzerman AP, Heitman LH

Publikováno v: Molecular pharmacology [Mol Pharmacol] 2013 Oct; Vol. 84 (4), pp. 551-61. Date of Electronic Publication: 2013 Jul 22.

Determining the Sustainable Characteristic of the Iraq National Housing Policy 2010.

Autor: Hameed, Ali Majid, Dhumad, Kadhim F.

Publikováno v: International Review of Civil Engineering; Mar2024, Vol. 15 Issue 2, p161-171, 11p

Energy efficiency, carbon emissions, and thermal comfort comparisons between conventional and proposed clustered open courtyard housing using CEB blocks.

Autor: Fahmy, M., Mahmoud, S., Abdelkhalik, H., Abdelalim, M., Elshelfa, M.

Publikováno v: IOP Conference Series: Earth & Environmental Science; 2022, Vol. 1056 Issue 1, p1-7, 7p