Výsledky vyhledávání - "Hafid, Laayouni"

Akademický článek

Positive selection in admixed populations from Ethiopia

Autor: Sandra Walsh, Luca Pagani, Yali Xue, Hafid Laayouni, Chris Tyler-Smith, Jaume Bertranpetit

Publikováno v: BMC Genetics, Vol 21, Iss S1, Pp 1-17 (2020)

Abstract Background In the process of adaptation of humans to their environment, positive or adaptive selection has played a main role. Positive selection has, however, been under-studied in African populations, despite their diversity and importance

Externí odkaz: https://doaj.org/article/4589caab418949808b1f554bc32d94e7

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VCF2Networks: applying Genotype Networks to Single Nucleotide Variants data

Autor: Dall'Olio, Giovanni Marco, Vahdati, Ali R., Jaume, Bertranpetit, Andreas, Wagner, Hafid, Laayouni

Summary: Genotype networks are a method used in systems biology to study the innovability of a given phenotype, determining whether the phenotype is robust to mutations, and how do the genotypes associated to it are distributed in the genotype space.

Externí odkaz: http://arxiv.org/abs/1401.2016

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Akademický článek

Chromosome X-wide Analysis of Positive Selection in Human Populations: Common and Private Signals of Selection and its Impact on Inactivated Genes and Enhancers

Autor: Pablo Villegas-Mirón, Sandra Acosta, Jessica Nye, Jaume Bertranpetit, Hafid Laayouni

Publikováno v: Frontiers in Genetics, Vol 12 (2021)

The ability of detecting adaptive (positive) selection in the genome has opened the possibility of understanding the genetic basis of population-specific adaptations genome-wide. Here, we present the analysis of recent selective sweeps, specifically

Externí odkaz: https://doaj.org/article/9452adfc91f54e0a990eb8c62d0b7d8e

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Akademický článek

Gene connectivity and enzyme evolution in the human metabolic network

Autor: Begoña Dobon, Ludovica Montanucci, Juli Peretó, Jaume Bertranpetit, Hafid Laayouni

Publikováno v: Biology Direct, Vol 14, Iss 1, Pp 1-14 (2019)

Abstract Background Determining the factors involved in the likelihood of a gene being under adaptive selection is still a challenging goal in Evolutionary Biology. Here, we perform an evolutionary analysis of the human metabolic genes to explore the

Externí odkaz: https://doaj.org/article/0b6dcfd5c8e742efb1c7d84085e63499

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Akademický článek

Evaluating the Genetics of Common Variable Immunodeficiency: Monogenetic Model and Beyond

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency characterized by recurrent infections, hypogammaglobulinemia and poor response to vaccines. Its diagnosis is made based on clinical and immunological cr

Externí odkaz: https://doaj.org/article/101b88bc2f1f4640aaf1b70c55b35578

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Akademický článek

Influence of pathway topology and functional class on the molecular evolution of human metabolic genes.

Autor: Ludovica Montanucci, Hafid Laayouni, Begoña Dobon, Kevin L Keys, Jaume Bertranpetit, Juli Peretó

Publikováno v: PLoS ONE, Vol 13, Iss 12, p e0208782 (2018)

Metabolic networks comprise thousands of enzymatic reactions functioning in a controlled manner and have been shaped by natural selection. Thanks to the genome data, the footprints of adaptive (positive) selection are detectable, and the strength of

Externí odkaz: https://doaj.org/article/72aa11f27ee54eff9723eee8fcdb0337

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Akademický článek

Correction: Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples.

Autor: Rajendra Mandage, Marco Telford, Juan Antonio Rodríguez, Xavier Farré, Hafid Laayouni, Urko M Marigorta, Caitlin Cundiff, Jose Maria Heredia-Genestar, Arcadi Navarro, Gabriel Santpere

Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0196623 (2018)

[This corrects the article DOI: 10.1371/journal.pone.0179446.].

Externí odkaz: https://doaj.org/article/a21e2442bad242b18d7b386f2859ed21

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Enhancers with tissue-specific activity are enriched in intronic regions

Autor: Pablo Villegas-Mirón, Roderic Guigó, Jaume Bertranpetit, Sandra Acosta, Hafid Laayouni, Alba Segarra-Casas, Sílvia Pérez-Lluch, Isabel Turpin, Beatrice Borsari

Publikováno v: Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Genome Res
Digital.CSIC. Repositorio Institucional del CSIC
instname

Tissue function and homeostasis reflect the gene expression signature by which the combination of ubiquitous and tissue-specific genes contribute to the tissue maintenance and stimuli-responsive function. Enhancers are central to control this tissue-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604ad8b89073d59a64391fcdac2480f7
http://hdl.handle.net/2445/195705

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Signatures of genetic variation in human microRNAs point to processes of positive selection and population-specific disease risks

Autor: Yolanda Espinosa Parrilla, Pablo Villegas-Mirón, Jaume Bertranpetit, Hafid Laayouni, Alcia Gallego

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

The occurrence of natural variation in human microRNAs has been the focus of numerous studies during the last 20 years. Most of them have been focused on the role of specific mutations in disease, while a minor proportion seek to analyse microRNA div

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ebc185ab0a4275df3f75fcaaa69f01
https://pubmed.ncbi.nlm.nih.gov/35249174

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