Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Haengsoon Park"'
Autor:
Jocelyn Rivera, Xiaoying Xu, Haengsoon Park, Lesley Schultz, Kamil Paruch, David A. Parry, Alvarez Carmen S, Emma Lees, Thierry O. Fischmann, Doll Ronald J, Tara M. Stauffer, Laura R. Rokosz, Chad E. Knutson, Wolfgang Seghezzi, Vincent S. Madison, Alan Hruza, Michael P. Dwyer, Ray Anthony James, Derek Wiswell, Mckittrick Brian A, Greg Tucker, Frances Shanahan, Nicole Sgambellone, Kerry Keertikar, Randall R. Rossman, Timothy J. Guzi, Vidyadhar M. Paradkar, Yaolin Wang, Quiao Zhou, Paul Kirschmeier, Amin A. Nomeir, Tin-Yau Chan, Courtney Brown
Publikováno v:
ACS Medicinal Chemistry Letters. 1:204-208
Inhibition of cyclin-dependent kinases (CDKs) has emerged as an attractive strategy for the development of novel oncology therapeutics. Herein is described the utilization of an in vivo screening approach with integrated efficacy and tolerability par
Autor:
Celia Kingsbury, Irina Neagu, Ming You, Haengsoon Park, Tsung H. Lin, Koc-Kan Ho, Elizabeth Quadros, Maria L. Webb, Michael Ohlmeyer, Yuefei Shao, Matthew Sills, Jeffrey J. Letourneau, Andrew G. Cole, Yingchun Lu, Earl F. Kimble, Jorge Quintero, Riviello Christopher, Ray Anthony James, Bojing Wang, Vidyadhar M. Paradkar, Adolph Bohnstedt, Kenneth C. Appell, David J. Diller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6788-6792
A novel class of Janus tyrosine kinase 3 (JAK3) inhibitors based on a 2-benzimidazoylpurinone core structure is described. Through substitution of the benzimidazoyl moiety and optimization of the N-9 substituent of the purinone, compound 24 was ident
Publikováno v:
Tetrahedron. 61:6352-6367
Only a limited number of ligands have been successfully employed for the Ni-catalyzed asymmetric hydrovinylation reaction. Diarylphosphinites, carrying b-acylamino groups prepared from readily available carbohydrates, in conjunction with highly disso
Publikováno v:
The Journal of Organic Chemistry. 68:8431-8446
Through a systematic examination of ligand and counterion effects, new protocols for a nearly quantitative and highly selective codimerization of ethylene and various functionalized vinylarenes have been discovered. In a typical reaction, 4-bromostyr
Autor:
Albert L. Casalnuovo, Nobuyoshi Nomura, Timothy A. Ayers, T. V. RajanBabu, Malay Nandi, Haengsoon Park, Jian Jin
Publikováno v:
Current Organic Chemistry. 7:301-316
In this era of heightened environmental awareness and ever-increasing demand for higher efficiency from chemical processes, one of the major challenges facing organic synthesis is the utilization of abundantly available carbon sources as precursors f
Publikováno v:
Chemistry - A European Journal. 5:1963-1968
New reaction conditions and stereochemical control elements for heterodimerization between ethylene (or propylene) and functionalized vinyl arenes are highlighted (see equation). For example, an enantioselective version of the hydrovinylation reactio
Publikováno v:
Inorganica Chimica Acta. 221:157-160
The isolation and characterization of the trimethylenesulfide-coordinated complex, [CpRu(PPh3)2(SC3H6)]CF3SO3, is reported. The structure of [CpRu(PPh3)2(SC3H6)]CF3SO3 was determined by X-ray diffraction techniques: monoclinic space group I2/a, a=23.
Publikováno v:
Inorganica Chimica Acta. 204:195-198
The isolation and characterization of two mercaptan complexes of the general formula [CpRu(PPh3)2(RSH)]BF4, where R=benzyl and phenethyl, were undertaken to model the substrate/catalyst interaction of the hydrode-sulfurization (HDS) process. The IR d
Publikováno v:
ChemInform. 29
Carbon-carbon bond forming reaction is arguably the most important type of bond construction in organic chemistry; yet, paucity of methods for the stereoselective incorporation of abundantly available carbon feedstocks such as CO, CO2, HCN, or simple
Publikováno v:
ChemInform. 33
The total synthesis of ustiloxin D, a highly potent inhibitor of microtubule assembly, has been achieved. Notable features are the use of nucleophilic aromatic substitution (SNAr) for the construction of a chiral tertiary alkyl-aryl ether linkage, Sh