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Abstract P1-11-03: VRN101099, Brain Permeable HER2 Kinase Inhibitor, Shows the Anti-tumor Activity in Preclinical Models of HER2-positive Cancers

Autor: Yikyung Ko, Jihye yoo, Hong-ryul Jung, Hyerim Lim, YeongDeok Lee, Se Hyuk Kim, Dong Guk Shin, Serin Cho, Myung hoe Heo, Haelee Kim, Ha Yeon Cho, Ah Reum Han, Eunhwa Ko, Hwan Geun Choi, Deakwon Kim, Sunghwan Kim

Publikováno v: Cancer Research. 83:P1-11

The brain is a common target organ for breast cancer metastasis, and the risk of brain metastasis is usually high for patients with HER2-positive breast cancer. While T-DXd showed positive results in HER2-positive breast cancer brain metastasis (BCBM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2312641c1587a804507c69288b933ae0
https://doi.org/10.1158/1538-7445.sabcs22-p1-11-03

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X-ray Crystal Structure-Guided Design and Optimization of 7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor

Autor: Seo Kyung Ah, Son Jung Beom, Ikyon Kim, Jun Goo Jee, Nam Doo Kim, Kim Hyunkyung, Haelee Kim, Eunhwa Ko, Hwan Geun Choi, Younho Lee, Ha Yeon Cho

Publikováno v: Journal of Medicinal Chemistry. 64:6985-6995

Triple-negative breast cancer (TNBC) is an aggressive breast-cancer subtype associated with poor prognosis and high relapse rates. Monopolar spindle 1 kinase (MPS1) is an apical dual-specificity protein kinase that is over-expressed in TNBC. We herei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efd1e225ff0d0ed781f23a424e08089d
https://doi.org/10.1021/acs.jmedchem.1c00542

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Abstract LB521: Antitumor activity of potent RAF inhibitors in solid tumors with activated RAS-RAF axis

Autor: Kwangwoo Hwang, SeoHyun Jo, Jieun Choi, Ga-young Choi, Jiseon Choi, Ji-Hye Kwon, Dong-Guk Shin, Jiyeon Kim, Se-Hyuk Kim, Haelee Kim, Ha Yeon Cho, Jung Beom Son, Nam Doo Kim, Hwan Geun Choi, Daekwon Kim, Sunghwan Kim

Publikováno v: Cancer Research. 82:LB521-LB521

FDA approved three RAF inhibitors for the treatment of tumors containing BRAFV600 mutations, but one of the major drawbacks of these type I RAF inhibitors is to activate MAPK signaling pathway, instead of inhibiting signaling, which is referred to as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eed613962e35bc81098d392570afd873
https://doi.org/10.1158/1538-7445.am2022-lb521

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X-ray Crystal Structure-Guided Design and Optimization of 7

Autor: Younho, Lee, Hyunkyung, Kim, Haelee, Kim, Ha Yeon, Cho, Jun-Goo, Jee, Kyung-Ah, Seo, Jung Beom, Son, Eunhwa, Ko, Hwan Geun, Choi, Nam Doo, Kim, Ikyon, Kim

Publikováno v: Journal of medicinal chemistry. 64(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5318148535a7bed12adc0dfbcf524041
https://pubmed.ncbi.nlm.nih.gov/33942608

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Structural basis for the substrate recognition of peptidoglycan pentapeptides by Enterococcus faecalis VanYB

Autor: Hyunggu Hahn, Dong Man Jang, Byung Woo Han, Hyoun Sook Kim, Ha Na Im, Se Won Suh, Jieun Kim, Haelee Kim, Ji Yeon Lee, Jang Mi Back

Publikováno v: International Journal of Biological Macromolecules. 119:335-344

Vancomycin resistance in Enterococci and its transfer to methicillin-resistant Staphylococcus aureus are challenging problems in health care institutions worldwide. High-level vancomycin resistance is conferred by acquiring either transposable elemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c2639f73e9a3305619b7206e722807
https://doi.org/10.1016/j.ijbiomac.2018.07.081

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