Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Hae-Yong, Yoo"'
Autor:
Jin Hyun Kang, Seung Ho Lee, Jawon Lee, Murim Choi, Junhun Cho, Seok Jin Kim, Won Seog Kim, Young Hyeh Ko, Hae Yong Yoo
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background BCOR acts as a corepressor of BCL6, a potent oncogenic protein in cancers of the lymphoid lineage. We have found the recurrent somatic mutation of BCOR occurred in mature T-cell lymphoma (TCL). The role of BCOR mutation in lymphoi
Externí odkaz:
https://doaj.org/article/5c88070a7f0a4350b615e2809f19f99f
Autor:
Gyu Jin Lee, Yukyung Jun, Hae Yong Yoo, Yoon Kyung Jeon, Daekee Lee, Sanghyuk Lee, Jaesang Kim
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
A missense mutation in RHOA encoding p.Gly17 Val has been reported to occur frequently in angioimmunoblastic T-cell lymphoma (AITL). Here, we describe a murine model which expresses the human RHOA mutant gene product in a T-cell specific manner and d
Externí odkaz:
https://doaj.org/article/3d17cc0133224f0a988ebdea88222e0b
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4377 (2020)
Double-hit lymphoma (DHL) and double-expressor lymphoma (DEL) are aggressive forms of lymphoma that require better treatments to improve patient outcomes. CKD-581 is a new histone deacetylase (HDAC) inhibitor that exhibited a better safety profile in
Externí odkaz:
https://doaj.org/article/2c866506cdc143d58a8762de96824724
Autor:
Hae Yong Yoo, Pora Kim, Won Seog Kim, Seung Ho Lee, Sangok Kim, So Young Kang, Hye Yoon Jang, Jong-Eun Lee, Jaesang Kim, Seok Jin Kim, Young Hyeh Ko, Sanghyuk Lee
Publikováno v:
Haematologica, Vol 101, Iss 6 (2016)
CTLA4 and CD28 are co-regulatory receptors with opposite roles in T-cell signaling. By RNA sequencing, we identified a fusion between the two genes from partial gene duplication in a case of angioimmunoblastic T-cell lymphoma. The fusion gene, which
Externí odkaz:
https://doaj.org/article/0dc99a32ab6e42019f346ef2622c8790
Autor:
Young Hyeh Ko, Won Seog Kim, Inju Cho, Seok Jin Kim, Nara Yoon, Jiyeon Hyeon, Hae Yong Yoo, Jongmin Sim
Publikováno v:
Applied Immunohistochemistry & Molecular Morphology. 28:731-740
In the era of precision medicine, accurate and reproducible assignment of cell-of-origin (COO) in diffuse large B-cell lymphoma patients has become important. The Lymph2Cx assay is accurately determining COO by analyzing RNA expression of 20 selected
A highly recurrent novel missense mutation in CD28 among angioimmunoblastic T-cell lymphoma patients
Autor:
Seung Ho Lee, Ji Sun Kim, Jaesang Kim, Seok Jin Kim, Won Seog Kim, Sanghyuk Lee, Young Hyeh Ko, Hae Yong Yoo
Publikováno v:
Haematologica, Vol 100, Iss 12 (2015)
Externí odkaz:
https://doaj.org/article/5b5eddcd0f9b45698885f417d76f2834
Publikováno v:
The international journal of biochemistrycell biology. 143
MDC1, a mediator of DNA damage response, recruits other repair proteins on double-strand break (DSB) sites. MDC1 is necessary for activating checkpoint kinases Chk1 and Chk2. It is unclear whether Chk1 interacts with MDC1. MDC1 also comprises many di
Autor:
Seok Jin Kim, Mineui Hong, In-Gu Do, Seung Ho Lee, Kyung Ju Ryu, Hae Yong Yoo, Jung Yong Hong, Young Hyeh Ko, Won Seog Kim
Publikováno v:
Haematologica, Vol 100, Iss 3 (2015)
Externí odkaz:
https://doaj.org/article/3064cd49de7549c2910d44a1879abdb8
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126830 (2015)
Irinotecan, an analogue of camptothecin, is frequently used as a single agent or in combination with other anticancer drugs for the treatment of colorectal cancer. However, the drug resistance of tumors is a major obstacle to successful cancer treatm
Externí odkaz:
https://doaj.org/article/5dd0668e98ba4731bda57b85b45b89bb
Autor:
Daekee Lee, Yukyung Jun, Jaesang Kim, Gyu Jin Lee, Hae Yong Yoo, Yoon Kyung Jeon, Sanghyuk Lee
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
A missense mutation in RHOA encoding p.Gly17 Val has been reported to occur frequently in angioimmunoblastic T-cell lymphoma (AITL). Here, we describe a murine model which expresses the human RHOA mutant gene product in a T-cell specific manner and d