Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hae-Eun H. Park"'
Autor:
Eunah Kim, Andrea Annibal, Yujin Lee, Hae-Eun H. Park, Seokjin Ham, Dae-Eun Jeong, Younghun Kim, Sangsoon Park, Sujeong Kwon, Yoonji Jung, JiSoo Park, Sieun S. Kim, Adam Antebi, Seung-Jae V. Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Accumulating evidence indicates that mitochondria play crucial roles in immunity. However, the role of the mitochondrial Krebs cycle in immunity remains largely unknown, in particular at the organism level. Here we show that mitochondrial ac
Externí odkaz:
https://doaj.org/article/76ceadb6d9c14ef9a0dd85f7da8d2b66
Autor:
Hae-Eun H. Park, Wooseon Hwang, Seokjin Ham, Eunah Kim, Ozlem Altintas, Sangsoon Park, Heehwa G. Son, Yujin Lee, Dongyeop Lee, Won Do Heo, Seung-Jae V. Lee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Mutations in daf-2/insulin/IGF-1 receptor impair the growth and reproduction of C. elegans but conversely enhance immunity and lifespan. Here, the authors show that a missense mutation in the gene retains the effects on lifespan and immunity and impr
Externí odkaz:
https://doaj.org/article/4be13eaae3814a74aa5a5c7e9ff9e0a6
Publikováno v:
Translational Medicine of Aging, Vol 1, Iss , Pp 24-31 (2017)
RNA helicases are members of a large family of enzymes that function in unwinding RNA duplexes and modulating interactions between RNAs and proteins. RNA helicases participate in numerous cellular processes, including transcription, translation, mRNA
Externí odkaz:
https://doaj.org/article/714ad549a104438f8491de8b804337d3
Autor:
Sangsoon Park, Yoonji Jung, Seon Woo A. An, Heehwa G. Son, Wooseon Hwang, Dongyeop Lee, Murat Artan, Hae-Eun H. Park, Dae-Eun Jeong, Yujin Lee, Seung-Jae V. Lee
Publikováno v:
F1000Research, Vol 6 (2017)
Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of α-arrestins in the longevity of Caenorhabditi
Externí odkaz:
https://doaj.org/article/d778e6352493489fae62592a3b9798f3
Autor:
Sangsoon Park, Yoonji Jung, Seon Woo A. An, Heehwa G. Son, Wooseon Hwang, Dongyeop Lee, Murat Artan, Hae-Eun H. Park, Dae-Eun Jeong, Yujin Lee, Seung-Jae V. Lee
Publikováno v:
F1000Research, Vol 6 (2017)
Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of α-arrestins in the longevity of Caenorhabditi
Externí odkaz:
https://doaj.org/article/0e2ea24daffb419282d20c588166ab9d
Autor:
Seokjin Ham, Sieun S. Kim, Sangsoon Park, Eun Ji E. Kim, Sujeong Kwon, Hae-Eun H. Park, Yoonji Jung, Seung-Jae V. Lee
Publikováno v:
Genome Research. 32:2003-2014
Aging is associated with changes in a variety of biological processes at the transcriptomic level, including gene expression. Two types of aging occur during a lifetime: chronological and physiological aging. However, dissecting the difference betwee
Autor:
Yujin Lee, Ozlem Altintas, Seokjin Ham, Eunah Kim, Seung-Jae Lee, Won Do Heo, Hae-Eun H. Park, Wooseon Hwang, Dongyeop Lee, Sangsoon Park, Heehwa G. Son
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Insulin/IGF-1 signaling (IIS) regulates various physiological aspects in numerous species. In Caenorhabditis elegans, mutations in the daf-2/insulin/IGF-1 receptor dramatically increase lifespan and immunity, but generally impair motility, growth, an
Autor:
Seokjin, Ham, Sieun S, Kim, Sangsoon, Park, Eun Ji E, Kim, Sujeong, Kwon, Hae-Eun H, Park, Yoonji, Jung, Seung-Jae V, Lee
Publikováno v:
Genome research.
Aging is associated with changes in a variety of biological processes at the transcriptomic level, including gene expression. Two types of aging occur during life time: chronological and physiological aging. However, dissecting the difference between
Autor:
Sangsoon Park, Yunji Choi, Seung-Jae Lee, Murat Artan, Kyuhyung Kim, Dae-Eun Jeong, Hae-Eun H. Park, Yoonji Jung, Heehwa G. Son, Sieun S. Kim, Jin I. Lee
Publikováno v:
Aging Cell
Dietary restriction extends lifespan in various organisms by reducing the levels of both nutrients and non‐nutritional food‐derived cues. However, the identity of specific food‐derived chemical cues that alter lifespan remains unclear. Here, we
Autor:
Yujin Lee, Yoonji Jung, Seokjin Ham, Hae-Eun H. Park, Sujeong Kwon, Wooseon Hwang, Seung-Jae Lee, Jasmine Ashraf, Coleen T. Murphy, Dae-Eun Jeong
Publikováno v:
The Journal of Cell Biology
Immunosenescence, or immune aging, is a hallmark of aging. This study shows that inhibition of insulin/IGF-1 receptor reverses immunosenescence in the roundworm Caenorhabditis elegans through a feedback circuit comprising FOXO, HSF-1, and bZIP transc