Výsledky vyhledávání - "Hae Yong Pae"

Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms

Autor: Matthew McMillin, Hae Yong Pae, Gabriel Frampton, Sharon DeMorrow, Matthew A. Quinn, Cheryl Galindo

Publikováno v: Digestive and Liver Disease. 46:527-534

Background The blood brain barrier tightly regulates the passage of molecules into the brain and becomes leaky following obstructive cholestasis. The aim of this study was to determine if increased serum bile acids observed during cholestasis permeab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec4d2819c9c63d66d8180ae5e40a56fd
https://doi.org/10.1016/j.dld.2014.01.159

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Neuropeptide Y inhibits biliary hyperplasia of cholestatic rats by paracrine and autocrine mechanisms

Autor: Gabriel Frampton, Fanyin Meng, Romina Mancinelli, Paolo Onori, Kelly McDaniel, Julie Venter, Dinorah Leyva-Illades, Gianfranco Alpini, Matthew A. Quinn, Shannon Glaser, Antonio Franchitto, Eugenio Gaudio, Hae Yong Pae, Heather Francis, Sharon DeMorrow

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 305:G250-G257

Neuropeptide Y (NPY) exerts its functions through six subtypes of receptors (Y1–Y6). Biliary homeostasis is regulated by several factors through autocrine/paracrine signaling. NPY inhibits cholangiocarcinoma growth; however, no information exists r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d391d7babe535e462ad2e623eafe5d
https://doi.org/10.1152/ajpgi.00140.2013

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The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1

Autor: Cheryl Galindo, Matthew McMillin, Hae Yong Pae, Gabriel Frampton, Sharon DeMorrow, Matthew A. Quinn, Dinorah Leyva-Illades, Yoshiyuki Ueno

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 303:G1202-G1211

Progranulin (PGRN), a secreted growth factor, regulates the proliferation of various epithelial cells. Its mechanism of action is largely unknown. Sirtuin 1 (Sirt1) is a protein deacetylase that is known to regulate the transcriptional activity of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f523e5cffa839d8e0ff9018425e4279
https://doi.org/10.1152/ajpgi.00104.2012

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Suppression of the HPA axis during extrahepatic biliary obstruction induces cholangiocyte proliferation in the rat

Autor: Matthew A. Quinn, Matthew McMillin, Li Huang, Hae Yong Pae, Heather Francis, Sharon DeMorrow, Gabriel Frampton, Yoshiyuki Ueno, Cheryl Galindo, Darijana Horvat

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 302:G182-G193

Cholestatic patients often present with clinical features suggestive of adrenal insufficiency. In the bile duct-ligated (BDL) model of cholestasis, the hypothalamic-pituitary-adrenal (HPA) axis is suppressed. The consequences of this suppression on c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b135b658b594a088a8e438b3d85916
https://doi.org/10.1152/ajpgi.00205.2011

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Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism

Autor: Sharon DeMorrow, Brandon Cooper, Lorenza Rimassa, Cheryl Galindo, Darijana Horvat, Li Huang, Matthew A. Quinn, Matthew McMillin, Gabriel Frampton, Hae Yong Pae, Francesca Bernuzzi, Pietro Invernizzi

Publikováno v: Gut. 61:268-277

Background and objectives Cholangiocarcinoma is a devastating cancer of biliary origin with limited treatment options. The growth factor, progranulin, is overexpressed in a number of tumours. The study aims were to assess the expression of progranuli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aced780f78f88e8d1428b3dc6caf4f73
https://doi.org/10.1136/gutjnl-2011-300643

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Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor

Autor: Darijana Horvat, Hae Yong Pae, Jonathan Ramirez, Sharon DeMorrow, Li Huang, Lessie E. Golden, Gabriel Frampton, Li Jian Liang, Matthew A. Quinn

Publikováno v: Laboratory investigation; a journal of technical methods and pathology

Cholangiocarcinomas are devastating cancers of biliary origin with limited treatment options. It has previously been shown that the endocannabinoid anandamide exerts antiproliferative effects on cholangiocarcinoma independent of any known cannabinoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe4fa8ebc77f2b92eced1c754f172ec
https://doi.org/10.1038/labinvest.2011.62

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