Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Hae J. Park"'
Autor:
Hae J. Park, Mark A. Gregory
Publikováno v:
Aging and Cancer, Vol 4, Iss 2, Pp 51-73 (2023)
Abstract Prior to the past few years, the development of new therapies for acute myeloid leukemia (AML) has been disappointingly slow. For several decades, the standard therapy for AML has consisted of intensive induction chemotherapy, and potentiall
Externí odkaz:
https://doaj.org/article/6984a81060784b0ea3a71f188d76cc5c
Autor:
James DeGregori, Angelo D’Alessandro, Kirk C. Hansen, Craig T. Jordan, Biniam Adane, Sarah Gehrke, Vadym Zaberezhnyy, Hae J. Park, Travis Nemkov, Mark A. Gregory
Purpose:Acute myeloid leukemia (AML) is a hematologic malignancy characterized by the accumulation of immature myeloid precursor cells. AML is poorly responsive to conventional chemotherapy and a diagnosis of AML is usually fatal. More effective and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f50f1cb7f49b0786b023d0bffbc36a
https://doi.org/10.1158/1078-0432.c.6527879.v1
https://doi.org/10.1158/1078-0432.c.6527879.v1
Autor:
James DeGregori, Angelo D’Alessandro, Kirk C. Hansen, Craig T. Jordan, Biniam Adane, Sarah Gehrke, Vadym Zaberezhnyy, Hae J. Park, Travis Nemkov, Mark A. Gregory
Figure S1. The glutaminase inhibitor CB-839 impairs glutathione metabolism in FLT3WT AML cells. Figure S2. The glutaminase inhibitor CB-839 decreases glutathione levels, but does not increase total cellular ROS levels in AML cells. Figure S3. Antioxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49be6a43542813bd64bae76d97a7a934
https://doi.org/10.1158/1078-0432.22471412.v1
https://doi.org/10.1158/1078-0432.22471412.v1
Autor:
Hae J Park, Mark A Gregory, Vadym Zaberezhnyy, Andrew Goodspeed, Craig T Jordan, Jeffrey S Kieft, James DeGregori
While leukemic cells are susceptible to various therapeutic insults, residence in the bone marrow microenvironment typically confers protection from a wide range of drugs. Thus, understanding the unique molecular changes elicited by the marrow is of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519d28214f76d0bdb0b8e1719708eb54
https://doi.org/10.1101/2022.02.14.480468
https://doi.org/10.1101/2022.02.14.480468
Autor:
Sarah Gehrke, Hae J. Park, Vadym Zaberezhnyy, James DeGregori, Kirk C. Hansen, Biniam Adane, Mark A. Gregory, Angelo D'Alessandro, Craig T. Jordan, Travis Nemkov
Publikováno v:
Clin Cancer Res
Purpose: Acute myeloid leukemia (AML) is a hematologic malignancy characterized by the accumulation of immature myeloid precursor cells. AML is poorly responsive to conventional chemotherapy and a diagnosis of AML is usually fatal. More effective and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d089603b84104eb32c9f4bc8ded63af
https://doi.org/10.1158/1078-0432.ccr-18-3223
https://doi.org/10.1158/1078-0432.ccr-18-3223
Publikováno v:
Cancer Research. 81:1442-1442
Internal tandem duplication (ITD) mutations in FMS-like tyrosine kinase 3 (FLT3) are among the most common mutations in acute myeloid leukemia (AML) and are associated with poor prognosis. FLT3-ITD causes constitutive activation of FLT3, and the stro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d18e8adc14d8b3b4859ffabb82d6c2f
https://doi.org/10.1158/1538-7445.am2021-1442
https://doi.org/10.1158/1538-7445.am2021-1442
Autor:
David H. Ellison, Bethzaida Yarbrough, Kayla J. Erspamer, Rebecca A. Lazelle, Chao Ling Yang, Mohammed Z. Ferdaus, James A. McCormick, Nicholas P. Meermeier, Andrew S. Terker, Hae J. Park
Publikováno v:
Journal of the American Society of Nephrology. 27:2436-2445
Excess aldosterone is an important contributor to hypertension and cardiovascular disease. Conversely, low circulating aldosterone causes salt wasting and hypotension. Aldosterone activates mineralocorticoid receptors (MRs) to increase epithelial sod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2b5722574ee48bd6e0c3388c6db558
https://doi.org/10.1681/asn.2015070815
https://doi.org/10.1681/asn.2015070815
Publikováno v:
American Journal of Physiology-Renal Physiology. 305:F1687-F1696
The cation cotransporters Na+-K+-2Cl− cotransporter 1 and 2 (NKCC1 and NKCC2) and Na+-Cl cotransporter (NCC) are phosphorylated and activated by the kinases Ste20-related proline alanine-rich kinase (SPAK) and oxidative stress-responsive kinase (OS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b7284e01f3578ccbbd0f7fbcf321cb
https://doi.org/10.1152/ajprenal.00211.2013
https://doi.org/10.1152/ajprenal.00211.2013
Autor:
Hae J. Park, Gregory C. Finnigan, Glen E. Cronan, Tom H. Stevens, Shuba Srinivasan, Florante A. Quiocho
Publikováno v:
Journal of Biological Chemistry. 287:19487-19500
Subunit a of the yeast vacuolar-type, proton-translocating ATPase enzyme complex (V-ATPase) is responsible for both proton translocation and subcellular localization of this highly conserved molecular machine. Inclusion of the Vph1p isoform causes th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8cffad19d74819b3d607146e98289c6
https://doi.org/10.1074/jbc.m112.343814
https://doi.org/10.1074/jbc.m112.343814