Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Hae J Park"'
Autor:
Hae J Park, Mark A Gregory, Vadym Zaberezhnyy, Andrew Goodspeed, Craig T Jordan, Jeffrey S Kieft, James DeGregori
Publikováno v:
eLife, Vol 11 (2022)
While leukemic cells are susceptible to various therapeutic insults, residence in the bone marrow microenvironment typically confers protection from a wide range of drugs. Thus, understanding the unique molecular changes elicited by the marrow is of
Externí odkaz:
https://doaj.org/article/ea84268fcc014d5baa026f0532c4b188
Autor:
Hae J. Park, Mark A. Gregory
Publikováno v:
Aging and Cancer.
Autor:
James DeGregori, Angelo D’Alessandro, Kirk C. Hansen, Craig T. Jordan, Biniam Adane, Sarah Gehrke, Vadym Zaberezhnyy, Hae J. Park, Travis Nemkov, Mark A. Gregory
Purpose:Acute myeloid leukemia (AML) is a hematologic malignancy characterized by the accumulation of immature myeloid precursor cells. AML is poorly responsive to conventional chemotherapy and a diagnosis of AML is usually fatal. More effective and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f50f1cb7f49b0786b023d0bffbc36a
https://doi.org/10.1158/1078-0432.c.6527879.v1
https://doi.org/10.1158/1078-0432.c.6527879.v1
Autor:
James DeGregori, Angelo D’Alessandro, Kirk C. Hansen, Craig T. Jordan, Biniam Adane, Sarah Gehrke, Vadym Zaberezhnyy, Hae J. Park, Travis Nemkov, Mark A. Gregory
Figure S1. The glutaminase inhibitor CB-839 impairs glutathione metabolism in FLT3WT AML cells. Figure S2. The glutaminase inhibitor CB-839 decreases glutathione levels, but does not increase total cellular ROS levels in AML cells. Figure S3. Antioxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49be6a43542813bd64bae76d97a7a934
https://doi.org/10.1158/1078-0432.22471412.v1
https://doi.org/10.1158/1078-0432.22471412.v1
Autor:
Sarah Gehrke, Hae J. Park, Vadym Zaberezhnyy, James DeGregori, Kirk C. Hansen, Biniam Adane, Mark A. Gregory, Angelo D'Alessandro, Craig T. Jordan, Travis Nemkov
Publikováno v:
Clin Cancer Res
Purpose: Acute myeloid leukemia (AML) is a hematologic malignancy characterized by the accumulation of immature myeloid precursor cells. AML is poorly responsive to conventional chemotherapy and a diagnosis of AML is usually fatal. More effective and
Publikováno v:
Cancer Research. 81:1442-1442
Internal tandem duplication (ITD) mutations in FMS-like tyrosine kinase 3 (FLT3) are among the most common mutations in acute myeloid leukemia (AML) and are associated with poor prognosis. FLT3-ITD causes constitutive activation of FLT3, and the stro
Autor:
David H. Ellison, Bethzaida Yarbrough, Kayla J. Erspamer, Rebecca A. Lazelle, Chao Ling Yang, Mohammed Z. Ferdaus, James A. McCormick, Nicholas P. Meermeier, Andrew S. Terker, Hae J. Park
Publikováno v:
Journal of the American Society of Nephrology. 27:2436-2445
Excess aldosterone is an important contributor to hypertension and cardiovascular disease. Conversely, low circulating aldosterone causes salt wasting and hypotension. Aldosterone activates mineralocorticoid receptors (MRs) to increase epithelial sod
Publikováno v:
American Journal of Physiology-Renal Physiology. 305:F1687-F1696
The cation cotransporters Na+-K+-2Cl− cotransporter 1 and 2 (NKCC1 and NKCC2) and Na+-Cl cotransporter (NCC) are phosphorylated and activated by the kinases Ste20-related proline alanine-rich kinase (SPAK) and oxidative stress-responsive kinase (OS
Autor:
Hae J. Park, Gregory C. Finnigan, Glen E. Cronan, Tom H. Stevens, Shuba Srinivasan, Florante A. Quiocho
Publikováno v:
Journal of Biological Chemistry. 287:19487-19500
Subunit a of the yeast vacuolar-type, proton-translocating ATPase enzyme complex (V-ATPase) is responsible for both proton translocation and subcellular localization of this highly conserved molecular machine. Inclusion of the Vph1p isoform causes th