Výsledky vyhledávání - "Hadya M. Khawaja"

ATP binding cassette C1 (ABCC1/MRP1)-mediated drug efflux contributes to disease progression in T-lineage acute lymphoblastic leukemia

Autor: Richard S. Larson, Jerec W. Ricci, Li Luo, Hadya M. Khawaja, Tasha Serna-Gallegos, Debbie M. Lovato, Stuart S. Winter, Natalie DeBassige

Publikováno v: Health. :41-50

Purpose: In acute lymphoblastic leukemia (ALL), multidrug resistance is often mediated by AT- Pase Binding Cassette (ABC) proteins, which principally involve ABCC1 (multidrug resistance protein 1, MRP1) and ABCB1 (multidrug resistance 1, MDR1). Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974eb777779316bc94e1ee17d1b8a687
https://doi.org/10.4236/health.2013.55a005

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High-Throughput Flow Cytometry to Detect Selective Inhibitors of ABCB1, ABCC1, and ABCG2 Transporters

Autor: Irena Ivnitski-Steele, Bruce S. Edwards, Hadya M. Khawaja, Tudor I. Oprea, Richard S. Larson, Stuart S. Winter, Debbie M. Lovato, Larry A. Sklar

Publikováno v: ASSAY and Drug Development Technologies. 6:263-276

Up-regulation of pump (transporter) expression and selection of resistant cancer cells result in cancer multidrug resistance to diverse substrates of these transporters. While more than 48 members of the ATP binding cassette (ABC) transporter superfa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb633ce68da236a5042652c71276268
https://doi.org/10.1089/adt.2007.107

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High-Throughput Screening for Daunorubicin-Mediated Drug Resistance Identifies Mometasone Furoate as a Novel ABCB1-Reversal Agent

Autor: Tudor I. Oprea, Richard S. Larson, Larry A. Sklar, Susan M. Young, Irena D. Steele, Hadya M. Khawaja, Debbie M. Lovato, Stuart S. Winter, Bruce S. Edwards

Publikováno v: SLAS Discovery. 13:185-193

The overexpression of P-glycoprotein, encoded by the ATP Binding Cassette B1 (ABCB1) gene, contributes to multidrug resistance (MDR) and is considered one of the major obstacles to successful cancer chemotherapy. The authors previously developed a T-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1154e9384d573e68ffa9f48fafbb4a3a
https://doi.org/10.1177/1087057108314610

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Genetic alterations determine chemotherapy resistance in childhood T-ALL: modelling in stage-specific cell lines and correlation with diagnostic patient samples

Autor: Richard S. Larson, Stuart S. Winter, David A. Estes, Hadya M. Khawaja, Debbie M. Lovato

Publikováno v: British Journal of Haematology. 139:20-30

Acquired drug resistance eventually leads to treatment failure in T-cell acute lymphoblastic leukaemia (T-ALL). Immunophenotypic and cytogenetic heterogeneities within T-ALL influence susceptibility to cytotoxic therapy, and little is known about the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559b5e39baebbdafaaa69bbd7c43c981
https://doi.org/10.1111/j.1365-2141.2007.06763.x

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Identification of genomic classifiers that distinguish induction failure in T-lineage acute lymphoblastic leukemia: a report from the Children's Oncology Group

Autor: Hadya M. Khawaja, Zeyu Jiang, Barbara L. Asselin, Timothy C. Griffin, Richard S. Larson, Meenakshi Devidas, Stuart S. Winter

Publikováno v: Blood. 110:1429-1438

The clinical and cytogenetic features associated with T-cell acute lymphoblastic leukemia (T-ALL) are not predictive of early treatment failure. Based on the hypothesis that microarrays might identify patients who fail therapy, we used the Affymetrix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115d307486129c8805bdcb0be28b40fc
https://doi.org/10.1182/blood-2006-12-059790

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De Novo Expression of ATP Binding Cassette C1 (ABCC1) on T-ALL Cells Confers Resistance to Vincristine Independent of an MDR1 Phenotype

Autor: Stuart S. Winter, Debbie M. Lovato, Richard S. Larson, Hadya M. Khawaja

Publikováno v: Blood. 110:2374-2374

Acquired drug resistance eventually leads to treatment failure in T-cell acute lymphoblastic leukemia (T-ALL). To define mechanisms of vincristine (VCR)-resistance, and to address whether inducible resistance in T-ALL might be mechanistically-depende

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b124ef58964f851e405e3f4ef9b587e
https://doi.org/10.1182/blood.v110.11.2374.2374

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Identification of Off-Patent Drugs That Reverse Daunorubicin Efflux Mediated by ABCB1 in T-ALL Cells

Autor: Bruce S. Edwards, Stuart S. Winter, Irena D. Steele, Tudor I. Oprea, Richard S. Larson, Hadya M. Khawaja, Susan M. Young, Debbie M. Lovato, Larry A. Sklar

Publikováno v: Blood. 108:2603-2603

In acute leukemias, the overexpression of P-glycoprotein, encoded by the ATP Binding Cassette B1 (ABCB1) gene contributes to multidrug resistance (MDR), and is considered one of the major obstacles to successful cancer chemotherapy. The identificatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3964cefb8100cffad3f38ee661eb8de
https://doi.org/10.1182/blood.v108.11.2603.2603

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Identification of Chemotherapy-Resistant Mechanisms in Childhood T-ALL Cell Lines: Correlation with Genetic Profiles in Patients Having Early Treatment Failure

Autor: David A. Estes, Richard S. Larson, Hadya M. Khawaja, Debbie M. Lovato, Stuart S. Winter

Publikováno v: Blood. 108:4376-4376

Acquisition of drug resistance in childhood T-cell acute lymphoblastic leukemia (T-ALL) is a major cause of treatment failure. Drug resistant cell lines are effective tools for elucidating mechanisms of acquired drug resistance. In this study, we dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::571756f546d56fa2c0b3af7c6514e8e1
https://doi.org/10.1182/blood.v108.11.4376.4376

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Identification of Genomic Classifiers That Distinguish Induction Failure in T-Lineage Acute Lymphoblastic Leukemia in COG Study 9404

Autor: Stuart S. Winter, Zeyu Jiang, Barbara L. Asselin, Richard S. Larson, Timothy C. Griffin, Hadya M. Khawaja

Publikováno v: Blood. 108:1826-1826

The clinical features of age, white count, and presence of extramedullary disease cannot predict risk for induction failure (IF) in patients who present with T-cell acute lymphoblastic leukemia (T-ALL). On the basis of recent observations that gene e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82f0d82fa6dacdb92af997e74fe57f2f
https://doi.org/10.1182/blood.v108.11.1826.1826

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Establishment and Indentification of Genetic Alterations in Chemotherapy-Resistant T-ALL Cell Lines

Autor: Hadya M. Khawaja, Rahul Poria, Richard S. Larson, Debbie M. Lovato, Stuart S. Winter, David A. Estes, Claudia L. Quan

Publikováno v: Blood. 106:4423-4423

Acquisition of drug resistance in tumor cells in children with T-cell acute lymphoblastic leukemia (T-ALL) during chemotherapy results in relapse and poor outcome. T-ALL cell lines that have acquired resistance to chemotherapeutics are therefore crit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5fb006dbc85920b26591bd1da154ccb
https://doi.org/10.1182/blood.v106.11.4423.4423

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