Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Hadley D, Sikes"'
Publikováno v:
ACS Omega, Vol 9, Iss 41, Pp 42612-42612 (2024)
Externí odkaz:
https://doaj.org/article/0e5bcefa8e1541fe8906d0cf7b864a77
Autor:
Allison Sheen, Yash Agarwal, Keith M. Cheah, Sarah C. Cowles, Jordan A. Stinson, Joseph R. Palmeri, Hadley D. Sikes, K. Dane Wittrup
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102766- (2023)
Catalase is an antioxidant enzyme that catalyzes the rapid conversion of hydrogen peroxide to water and oxygen. Use of catalase as a cancer therapeutic has been proposed to reduce oxidative stress and hypoxia in the tumor microenvironment, both activ
Externí odkaz:
https://doaj.org/article/bdc02fa1657a4226b9e43defbfbf2f40
Autor:
Patthara Kongsuphol, Huan Jia, Hoi Lok Cheng, Yue Gu, Bhuvaneshwari D/O Shunmuganathan, Ming Wei Chen, Sing Mei Lim, Say Yong Ng, Paul Ananth Tambyah, Haziq Nasir, Xiaohong Gao, Dousabel Tay, Seunghyeon Kim, Rashi Gupta, Xinlei Qian, Mary M. Kozma, Kiren Purushotorman, Megan E. McBee, Paul A. MacAry, Hadley D. Sikes, Peter R. Preiser
Publikováno v:
Communications Medicine, Vol 1, Iss 1, Pp 1-12 (2021)
Kongsuphol et al. develop a paper-based, vertical flow assay to detect SARS-CoV-2 neutralizing antibodies. The point-of-care assay has comparable performance to lab-based tests and provides results in 10 min.
Externí odkaz:
https://doaj.org/article/663f8b27aead4a418e60988c13e46a00
Autor:
Hoi Lok Cheng, Sing Mei Lim, Huan Jia, Ming Wei Chen, Say Yong Ng, Xiaohong Gao, Jyoti Somani, Sharmila Sengupta, Dousabel M. Y. Tay, Patrina W. L. Chua, Abirami R., Sharon Y. H. Ling, Megan E. McBee, Barnaby E. Young, Hadley D. Sikes, Peter R. Preiser
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT As the COVID-19 pandemic continues, countries around the world are switching toward vaccinations and boosters to combat the pandemic. However, waning immunity against SARS-CoV-2 wild-type (WT) and variants have been widely reported. Booster
Externí odkaz:
https://doaj.org/article/6651f04433e54122ae0f8bff3b6af7b6
Cellular lensing and near infrared fluorescent nanosensor arrays to enable chemical efflux cytometry
Autor:
Soo-Yeon Cho, Xun Gong, Volodymyr B. Koman, Matthias Kuehne, Sun Jin Moon, Manki Son, Tedrick Thomas Salim Lew, Pavlo Gordiichuk, Xiaojia Jin, Hadley D. Sikes, Michael S. Strano
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The authors present nanosensor chemical cytometry, based on an array of nIR fluorescent single walled carbon nanotube integrated along a microfluidic channel. The lensing effect of the flowing cells allows for extracting information, and correlating
Externí odkaz:
https://doaj.org/article/76b3086d1f494823843a8f3065ef14f2
Autor:
Sing Mei Lim, Hoi Lok Cheng, Huan Jia, Patthara Kongsuphol, Bhuvaneshwari D/O Shunmuganathan, Ming Wei Chen, Say Yong Ng, Xiaohong Gao, Shuvan Prashant Turaga, Sascha P. Heussler, Jyoti Somani, Sharmila Sengupta, Dousabel M. Y. Tay, Megan E. McBee, Barnaby E. Young, Paul A. MacAry, Hadley D. Sikes, Peter R. Preiser
Publikováno v:
Bioengineering & Translational Medicine, Vol 7, Iss 2, Pp n/a-n/a (2022)
Abstract There is clinical need for a quantifiable point‐of‐care (PoC) SARS‐CoV‐2 neutralizing antibody (nAb) test that is adaptable with the pandemic's changing landscape. Here, we present a rapid and semi‐quantitative nAb test that uses f
Externí odkaz:
https://doaj.org/article/d63c818224ae4a54916797daab64c017
Autor:
Huan Jia, Nazirulmubin Abdul Moomen, Jeanette Leong, Patthara Kongsuphol, Zhi Feng Sherman Lim, Carmen Sze Min Pui, Yuxuan Tan, Ki-Joo Sung, Hadley D. Sikes
Publikováno v:
Sensors & Diagnostics. 2:627-631
Protein engineering approach enables effective immobilisation of thermostable affinity proteins onto polystyrene materials.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84bf33da111ae6d36c512dbe393c1ab5
https://doi.org/10.1039/d3sd00041a
https://doi.org/10.1039/d3sd00041a
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 9, p e1008202 (2020)
Hydrogen peroxide (H2O2) promotes a range of phenotypes depending on its intracellular concentration and dosing kinetics, including cell death. While this qualitative relationship has been well established, the quantitative and mechanistic aspects of
Externí odkaz:
https://doaj.org/article/e94eb91d5e5a445ba66241a27cefa7dd
Publikováno v:
Bioengineering & Translational Medicine, Vol 5, Iss 3, Pp n/a-n/a (2020)
Abstract Mitochondrial NADPH protects cells against mitochondrial oxidative stress by serving as an electron donor to antioxidant defense systems. However, due to technical challenges, it still remains unknown as to the pool size of mitochondrial NAD
Externí odkaz:
https://doaj.org/article/4e5285e322e34144b5b876cc9b2fc6a8
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Current sensors for intracellular H2O2 are not sensitive enough to detect all biologically relevant H2O2 fluctuations. Here the authors develop a peroxiredoxin-2-based FRET probe that is sensitive enough to measure changes in H2O2 concentration in re
Externí odkaz:
https://doaj.org/article/1ada60e3af9c4daab6f468fb7f0175c1