Characterization of therapeutic antibody efficacy against multiple SARS-CoV-2 variants in the hamster model

Autor: Cong, Yu, Dixit, Saurabh, Perry, Donna L., Huzella, Louis M., Kollins, Erin, Byrum, Russell, Anthony, Scott M., Drawbaugh, David, Lembirik, Sanae, Postnikova, Elena, Eaton, Brett, Murphy, Michael, Kocher, Gregory, Hadley, Kyra, Marketon, Anthony E., Bernbaum, Rebecca M., Hischak, Amanda M.W., Hart, Randy, Vaughan, Nick, Wada, Jiro, Qin, Jing, St Claire, Marisa C., Schmaljohn, Connie S., Holbrook, Michael R.

Publikováno v: In Antiviral Research October 2024 230

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Antiviral innate immunity is diminished in the upper respiratory tract of severe COVID-19 patients.

Autor: Ramos-Benitez MJ; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD.; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.; Postdoctoral Research Associate Training Program, National Institute of General Medical Sciences, Bethesda, MD 20892.; Ponce Health Science University and Ponce Research Institute, Department of Basic Sciences, School of Medicine, Ponce, Puerto Rico, USA., Strich JR; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD.; The United States Public Health Service Commissioned Corps, Rockville, MD, USA., Alehashemi S; Translational Autoinflammatory Diseases Section (TADS), Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy, and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA., Stein S; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD.; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Rastegar A; Translational Autoinflammatory Diseases Section (TADS), Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy, and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA., de Jesus AA; Translational Autoinflammatory Diseases Section (TADS), Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy, and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA., Bhuyan F; Translational Autoinflammatory Diseases Section (TADS), Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy, and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA., Ramelli S; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD., Babyak A; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD.; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Perez-Valencia L; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD.; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Vannella KM; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD.; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Grubbs G; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD., Khurana S; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD., Gross R; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD., Hadley K; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD., Liang J; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD., Mazur S; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD., Postnikova E; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD., Warner S; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD., Holbrook MR; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD., Busch LM; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD., Warner B; Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA., Applefeld W; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD., Warner S; The United States Public Health Service Commissioned Corps, Rockville, MD, USA., Kadri SS; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD., Davey RT; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Goldbach-Mansky R; Translational Autoinflammatory Diseases Section (TADS), Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy, and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA., Chertow DS; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD.; The United States Public Health Service Commissioned Corps, Rockville, MD, USA.; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2022 Nov 13. Date of Electronic Publication: 2022 Nov 13.