Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hadiar Rahman"'
Autor:
Hadiar Rahman, Mark J. Ware, Andaleeb Sajid, Sabrina Lusvarghi, Stewart R. Durell, Suresh V. Ambudkar
Publikováno v:
Cancers, Vol 15, Iss 13, p 3459 (2023)
P-glycoprotein (P-gp, ABCB1) transports structurally dissimilar hydrophobic and amphipathic compounds, including anticancer drugs, thus contributing to multidrug-resistant cancer. Cryo-EM structures of human P-gp revealed that TMHs 4 and 10 contribut
Externí odkaz:
https://doaj.org/article/ddf860e3e9494dfc8195c0efca83152e
Autor:
Hadiar Rahman, Andrew Rudrow, Joshua Carneglia, Sister Stephen Patrick Joly, Dante Nicotera, Michael Naldrett, John Choy, Suresh V. Ambudkar, John Golin
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 1, Pp 357-369 (2020)
Analysis of synonymous mutations established that although the primary amino acid sequence remains unchanged, alterations in transcription and translation can result in significant phenotypic consequences. We report the novel observation that a serie
Externí odkaz:
https://doaj.org/article/89a77273814c4f0dae149e2d027f1d00
Publikováno v:
Molecular Microbiology. 118:3-15
A significant portion of clinically observed antifungal resistance is mediated by ATP-binding cassette (ABC) and major facilitator superfamily (MFS) transport pumps that reside in the plasma membrane. We review the mechanisms responsible for this phe
Autor:
Maryam Alhumaidi, Lea-Marie Nentwig, Hadiar Rahman, Lutz Schmitt, Andrew Rudrow, Andrzej Harris, Cierra Dillon, Lucas Restrepo, Erwin Lamping, Nidhi Arya, Suresh V. Ambudkar, John S. Choy, John Golin
Publikováno v:
Journal of Biological Chemistry. 298:102689
ATP-binding cassette (ABC) multidrug transporters are large, polytopic membrane proteins that exhibit astonishing promiscuity for their transport substrates. These transporters unidirectionally efflux thousands of structurally and functionally distin
Autor:
John Golin, Suresh V. Ambudkar, Sister Stephen Patrick Joly, Michael J. Naldrett, Hadiar Rahman, Andrew Rudrow, John S. Choy, Dante Nicotera, Joshua Carneglia
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 1, Pp 357-369 (2020)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
Analysis of synonymous mutations established that although the primary amino acid sequence remains unchanged, alterations in transcription and translation can result in significant phenotypic consequences. We report the novel observation that a serie
Autor:
Lutz Schmitt, Manuel Wagner, Suresh V. Ambudkar, Hadiar Rahman, John Golin, Nidhi Arya, Andrew Rudrow
Publikováno v:
Mol Microbiol
Resistance to antimicrobial and chemotherapeutic agents is a significant clinical problem. Overexpression of multidrug efflux pumps often creates broad-spectrum resistance in cancers and pathogens. We describe a mutation, A666G, in the yeast ABC tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a5a25caf55119687e38e7fa9579529
https://europepmc.org/articles/PMC6800772/
https://europepmc.org/articles/PMC6800772/
Publikováno v:
FEMS Yeast Research
Saccharomyces cerevisiae has sophisticated nutrient-sensing programs for responding to harsh environments containing limited nutrients. As a result, yeast cells can live in diverse environments, including animals, as a commensal or a pathogen. Becaus