Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Hadi Falahatpisheh"'
Autor:
Puja Sapra, Hans-Peter Gerber, Christopher J. O'Donnell, Frank Loganzo, Edward Rosfjord, Judy Lucas, Lioudmila Tchistiakova, Frank Barletta, Tracey Clark, Martin Finkelstein, Hadi Falahatpisheh, Magali Guffroy, George Hu, Cynthia M. Rohde, Christine Hosselet, Jonathon Golas, Manoj B. Charati, Eric M. Bennett, Jeffrey Casavant, Jack Bikker, L. Nathan Tumey, Sujiet Puthenveetil, Kimberly Marquette, Bitha Narayanan, Dangshe Ma, Matthew Sung, Edmund I. Graziani
Effects of Systemic Administration of Free Payload Compared with Conventional HER2-vc0101 on Indicators of Bone Marrow Toxicity and Bone Marrow Payload Levels in Rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d432b6130242412350911c126917be78
https://doi.org/10.1158/1535-7163.22520919.v1
https://doi.org/10.1158/1535-7163.22520919.v1
Autor:
Puja Sapra, Hans-Peter Gerber, Christopher J. O'Donnell, Frank Loganzo, Edward Rosfjord, Judy Lucas, Lioudmila Tchistiakova, Frank Barletta, Tracey Clark, Martin Finkelstein, Hadi Falahatpisheh, Magali Guffroy, George Hu, Cynthia M. Rohde, Christine Hosselet, Jonathon Golas, Manoj B. Charati, Eric M. Bennett, Jeffrey Casavant, Jack Bikker, L. Nathan Tumey, Sujiet Puthenveetil, Kimberly Marquette, Bitha Narayanan, Dangshe Ma, Matthew Sung, Edmund I. Graziani
The approval of ado-trastuzumab emtansine (T-DM1) in HER2+ metastatic breast cancer validated HER2 as a target for HER2-specific antibody–drug conjugates (ADC). Despite its demonstrated clinical efficacy, certain inherent properties within T-DM1 ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1b894a20379dc9a76f654d4811688b
https://doi.org/10.1158/1535-7163.c.6542832
https://doi.org/10.1158/1535-7163.c.6542832
Autor:
Puja Sapra, Hans-Peter Gerber, Christopher J. O'Donnell, Frank Loganzo, Edward Rosfjord, Judy Lucas, Lioudmila Tchistiakova, Frank Barletta, Tracey Clark, Martin Finkelstein, Hadi Falahatpisheh, Magali Guffroy, George Hu, Cynthia M. Rohde, Christine Hosselet, Jonathon Golas, Manoj B. Charati, Eric M. Bennett, Jeffrey Casavant, Jack Bikker, L. Nathan Tumey, Sujiet Puthenveetil, Kimberly Marquette, Bitha Narayanan, Dangshe Ma, Matthew Sung, Edmund I. Graziani
Immunohistochemical evaluation of HER2 expression in vivo cell line and patient-derived xenograft models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3ff9f7c862c417038a9aae79602e4f
https://doi.org/10.1158/1535-7163.22520937
https://doi.org/10.1158/1535-7163.22520937
Autor:
Puja Sapra, Hans-Peter Gerber, Christopher J. O'Donnell, Frank Loganzo, Edward Rosfjord, Judy Lucas, Lioudmila Tchistiakova, Frank Barletta, Tracey Clark, Martin Finkelstein, Hadi Falahatpisheh, Magali Guffroy, George Hu, Cynthia M. Rohde, Christine Hosselet, Jonathon Golas, Manoj B. Charati, Eric M. Bennett, Jeffrey Casavant, Jack Bikker, L. Nathan Tumey, Sujiet Puthenveetil, Kimberly Marquette, Bitha Narayanan, Dangshe Ma, Matthew Sung, Edmund I. Graziani
Includes Supplementary Materials and Methods, Data and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03aca1bc8d20f2fe143c7aa7d3d27294
https://doi.org/10.1158/1535-7163.22520934
https://doi.org/10.1158/1535-7163.22520934
Autor:
Nasir Khan, Martin Finkelstein, Hans-Peter Gerber, Richard Giovanelli, Sharon Sokolowski, Chunli Huang, Danielle Sullivan, William Reagan, Timothy Coskran, Germaine Boucher, Richard Goldstein, Karen Walters, Leslie Obert, John Kreeger, Kathleen Biddle, Hadi Falahatpisheh, Magali Guffroy
Legends of supplementary figures 1, 2 and 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbf035dae9167ca70ae2357d0baa953
https://doi.org/10.1158/1078-0432.22465505
https://doi.org/10.1158/1078-0432.22465505
Autor:
Scott J. Dylla, Hans-Peter Gerber, Puja Sapra, Hadi Falahatpisheh, Frank Barletta, Robert Stull, Johannes Hampl, Orit Foord, Kathryn Loving, Timothy Nichols, Justin Lucas, Judy Lucas, Erik Upeslacis, Wenyan Zhong, Marybeth Pysz, Jeffrey Bernstein, Paul Escarpe, Elana Ernstoff, Virginia Pulito, Kiran Khandke, Sarah Fong, Monette Aujay, Marianne Santaguida, Wade Anderson, Jorge Aguilar, Albert Park, Alexander Bankovich, Marc Damelin
Purpose: Triple-negative breast cancer (TNBC) and ovarian cancer each comprise heterogeneous tumors, for which current therapies have little clinical benefit. Novel therapies that target and eradicate tumor-initiating cells (TIC) are needed to signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2ad6d27feffc9b7ae90f84aa16d05e
https://doi.org/10.1158/1078-0432.c.6523641.v1
https://doi.org/10.1158/1078-0432.c.6523641.v1
Autor:
Nasir Khan, Martin Finkelstein, Hans-Peter Gerber, Richard Giovanelli, Sharon Sokolowski, Chunli Huang, Danielle Sullivan, William Reagan, Timothy Coskran, Germaine Boucher, Richard Goldstein, Karen Walters, Leslie Obert, John Kreeger, Kathleen Biddle, Hadi Falahatpisheh, Magali Guffroy
There were no significant PF-0259-related changes in IL-6 throughout the study. Data are represented as mean ratios to baseline {plus minus} 1 standard deviation (SD).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4523f4e1f2d816c34671e67e6877ac
https://doi.org/10.1158/1078-0432.22465496.v1
https://doi.org/10.1158/1078-0432.22465496.v1
Autor:
Nasir Khan, Martin Finkelstein, Hans-Peter Gerber, Richard Giovanelli, Sharon Sokolowski, Chunli Huang, Danielle Sullivan, William Reagan, Timothy Coskran, Germaine Boucher, Richard Goldstein, Karen Walters, Leslie Obert, John Kreeger, Kathleen Biddle, Hadi Falahatpisheh, Magali Guffroy
PF-0259 did not induce platelet sequestration in spleen. Monkeys were dosed intravenously with vehicle or PF-0259 at 6 mg/m2/dose once every 3 weeks and were necropsied on Day 3 (at the time of platelet nadirs) or on Day 63 (at the end of the 3rd cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c80e160deb6d6434747f378503ea81
https://doi.org/10.1158/1078-0432.22465499.v1
https://doi.org/10.1158/1078-0432.22465499.v1
Autor:
Scott J. Dylla, Hans-Peter Gerber, Puja Sapra, Hadi Falahatpisheh, Frank Barletta, Robert Stull, Johannes Hampl, Orit Foord, Kathryn Loving, Timothy Nichols, Justin Lucas, Judy Lucas, Erik Upeslacis, Wenyan Zhong, Marybeth Pysz, Jeffrey Bernstein, Paul Escarpe, Elana Ernstoff, Virginia Pulito, Kiran Khandke, Sarah Fong, Monette Aujay, Marianne Santaguida, Wade Anderson, Jorge Aguilar, Albert Park, Alexander Bankovich, Marc Damelin
Supplementary Figures 1-4. Supplementary Figure 1. Analysis of EFNA4 copy number in breast and hepatocellular carcinoma. Supplementary Figure 2. Characterization of PF-06647263 conjugates. Supplementary Figure 3. Biomarkers of PF-06647263 activity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d14fed96e16e890f6829719918e5df
https://doi.org/10.1158/1078-0432.22457655.v1
https://doi.org/10.1158/1078-0432.22457655.v1
Autor:
Nasir Khan, Martin Finkelstein, Hans-Peter Gerber, Richard Giovanelli, Sharon Sokolowski, Chunli Huang, Danielle Sullivan, William Reagan, Timothy Coskran, Germaine Boucher, Richard Goldstein, Karen Walters, Leslie Obert, John Kreeger, Kathleen Biddle, Hadi Falahatpisheh, Magali Guffroy
PF-0259 did not induce platelet sequestration in kidney or lung. Monkeys were necropsied 48 hours after a single intravenous administration of vehicle or PF-0259 at 6 mg/m2. CD41 IHC for platelets was performed on kidney and lung samples from vehicle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f6476874c45a0d82ba4f2108f1dee9
https://doi.org/10.1158/1078-0432.22465502.v1
https://doi.org/10.1158/1078-0432.22465502.v1