Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Hadi Al-Hasani"'
Autor:
André Nguyen Dietzsch, Hadi Al-Hasani, Joachim Altschmied, Katharina Bottermann, Jana Brendler, Judith Haendeler, Susanne Horn, Isabell Kaczmarek, Antje Körner, Kerstin Krause, Kathrin Landgraf, Diana Le Duc, Laura Lehmann, Stefan Lehr, Stephanie Pick, Albert Ricken, Rene Schnorr, Angela Schulz, Martina Strnadová, Akhil Velluva, Heba Zabri, Torsten Schöneberg, Doreen Thor, Simone Prömel
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide prevalence. Understanding the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological inter
Externí odkaz:
https://doaj.org/article/b3c4ff1f595a49f8b5c14bc0d3761921
Autor:
Linda Große-Segerath, Paula Follert, Kristina Behnke, Julia Ettich, Tobias Buschmann, Philip Kirschner, Sonja Hartwig, Stefan Lehr, Mortimer Korf-Klingebiel, Daniel Eberhard, Nadja Lehwald-Tywuschik, Hadi Al-Hasani, Wolfram Trudo Knoefel, Stefan Heinrich, Bodo Levkau, Kai C. Wollert, Jürgen Scheller, Eckhard Lammert
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Recently, we have shown that after partial hepatectomy (PHx), an increased hepatic blood flow initiates liver growth in mice by vasodilation and mechanically-triggered release of angiocrine signals. Here, we use mass spectrometry to identify
Externí odkaz:
https://doaj.org/article/b17a84beedaf4e2c841ebb07a602c275
Autor:
Aleksandra Nikolic, Pia Fahlbusch, Nele-Kathrien Riffelmann, Natalie Wahlers, Sylvia Jacob, Sonja Hartwig, Ulrike Kettel, Martina Schiller, Matthias Dille, Hadi Al-Hasani, Jörg Kotzka, Birgit Knebel
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109276- (2024)
Summary: Chronic stress episodes increase metabolic disease risk even after recovery. We propose that persistent stress detrimentally impacts hepatic metabolic reprogramming, particularly mitochondrial function. In male C57BL/6 mice chronic variable
Externí odkaz:
https://doaj.org/article/a9a910623fc54e229460d2c5afb0c984
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1910 (2024)
Impaired skeletal muscle glucose uptake is a key feature in the development of insulin resistance and type 2 diabetes. Skeletal muscle glucose uptake can be enhanced by a variety of different stimuli, including insulin and contraction as the most pro
Externí odkaz:
https://doaj.org/article/63a3d73016604dfe869d7310643a2cec
Autor:
Inka Rapöhn, Ivet Elias, Juliane Weiner, Anna Pujol, Stephanie Kehr, Alexandra Chadt, Hadi Al-Hasani, Ralph Burkhardt, Nora Klöting, Michael Stumvoll, Fatima Bosch, Peter Kovacs, John T. Heiker, Jana Breitfeld
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Adipose tissue inflammation and insulin resistance are hallmarks in the development of metabolic diseases resulting from overweight and obesity, such as type 2 diabetes and non-alcoholic fatty liver disease. In obesity, adipocytes predominantly secre
Externí odkaz:
https://doaj.org/article/f7e50b71dc074a71be474ae2dec1aff1
Autor:
Anna Rita Minafra, Alexandra Chadt, Puyan Rafii, Hadi Al-Hasani, Kristina Behnke, Jürgen Scheller
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
High level of interleukin 6 (IL-6), released by adipocytes in an obesity-induced, low grade inflammation state, is a regulator of insulin resistance and glucose tolerance. IL-6 has also regenerative, anti-inflammatory and anti-diabetogenic functions,
Externí odkaz:
https://doaj.org/article/8bd209574140489582ca3c78868f9e4c
Autor:
Nele Zoellner, Noémi Coesfeld, Frederik Henry De Vos, Jennifer Denter, Haifeng C. Xu, Elena Zimmer, Birgit Knebel, Hadi Al-Hasani, Sofie Mossner, Philipp A. Lang, Doreen M. Floss, Jürgen Scheller
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Type I interferons (IFNs) are potent inhibitors of viral replication. Here, we reformatted the natural murine and human type I interferon-α/β receptors IFNAR1 and IFNAR2 into fully synthetic biological switches. The transmembrane and intracellular
Externí odkaz:
https://doaj.org/article/a844187356564f8ba83cf36bff594e71
E96V Mutation in the Kdelr3 Gene Is Associated with Type 2 Diabetes Susceptibility in Obese NZO Mice
Autor:
Delsi Altenhofen, Jenny Minh-An Khuong, Tanja Kuhn, Sandra Lebek, Sarah Görigk, Katharina Kaiser, Christian Binsch, Kerstin Griess, Birgit Knebel, Bengt-Frederik Belgardt, Sandra Cames, Samaneh Eickelschulte, Torben Stermann, Axel Rasche, Ralf Herwig, Jürgen Weiss, Heike Vogel, Annette Schürmann, Alexandra Chadt, Hadi Al-Hasani
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 845 (2023)
Type 2 diabetes (T2D) represents a multifactorial metabolic disease with a strong genetic predisposition. Despite elaborate efforts in identifying the genetic variants determining individual susceptibility towards T2D, the majority of genetic factors
Externí odkaz:
https://doaj.org/article/44ad1a367d59404983c913b62385a243
Autor:
Andrea Icks, Dan Ziegler, Alexander Strom, Gidon J Bönhof, Michael Roden, Christian Herder, Klaus Strassburger, Claudia Reule, Oliver Kuss, Gundega Sipola, Birgit Knebel, Jan-Christoph Wollmann, Hadi Al-Hasani
Publikováno v:
BMJ Open, Vol 12, Iss 2 (2022)
Introduction Diabetic sensorimotor polyneuropathy (DSPN) affects approximately 30% of people with diabetes, while around half of cases are symptomatic. Currently, there are only few pathogenetically oriented pharmacotherapies for DSPN, one of which i
Externí odkaz:
https://doaj.org/article/38ccbf1649494763b4f3a710d6222396
Autor:
Pia Fahlbusch, Aleksandra Nikolic, Sonja Hartwig, Sylvia Jacob, Ulrike Kettel, Cornelia Köllmer, Hadi Al-Hasani, Stefan Lehr, Dirk Müller-Wieland, Birgit Knebel, Jörg Kotzka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6873 (2022)
Alterations in mitochondrial function are an important control variable in the progression of metabolic dysfunction-associated fatty liver disease (MAFLD), while also noted by increased de novo lipogenesis (DNL) and hepatic insulin resistance. We hyp
Externí odkaz:
https://doaj.org/article/1784ba2a84ea419eaeab7d52d619b49b