Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hadi, Boukhatmi"'
Autor:
Mohamed H. Al-Sabri, Nourhane Ammar, Stanislava Korzh, Ahmed M. Alsehli, Kimia Hosseini, Robert Fredriksson, Jessica Mwinyi, Michael J. Williams, Hadi Boukhatmi, Helgi B. Schiöth
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Previously, we showed that fluvastatin treatment induces myofibrillar damage and mitochondrial phenotypes in the skeletal muscles of Drosophila. However, the sequential occurrence of mitochondrial phenotypes and myofibril damage remains elus
Externí odkaz:
https://doaj.org/article/f778552c72294911b629376c6860df04
Autor:
Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy Hin Yan Tong, Simonetta Andreazza, Juliette J. Lee, Lyudmila Nedyalkova, Matej Ušaj, Alexander J. Whitworth, Brenda J. Andrews, Jason Moffat, Chad L. Myers, Kris Gevaert, Charles Boone, Rui Gonçalo Martinho, Thomas Arnesen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)
Abstract Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-termina
Externí odkaz:
https://doaj.org/article/d00c6a73922e4ae69223e5ddad630fd5
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2024)
Three types of muscles, cardiac, smooth and skeletal muscles are classically distinguished in eubilaterian animals. The skeletal, striated muscles are innervated multinucleated syncytia, which, together with bones and tendons, carry out voluntary and
Externí odkaz:
https://doaj.org/article/12b5fdba51a84d9e88d49098c28f71c2
Autor:
Mohamed H. Al-Sabri, Neha Behare, Ahmed M. Alsehli, Samuel Berkins, Aadeya Arora, Eirini Antoniou, Eleni I. Moysiadou, Sowmya Anantha-Krishnan, Patricia D. Cosmen, Johanna Vikner, Thiago C. Moulin, Nourhene Ammar, Hadi Boukhatmi, Laura E. Clemensson, Mathias Rask-Andersen, Jessica Mwinyi, Michael J. Williams, Robert Fredriksson, Helgi B. Schiöth
Publikováno v:
Cells, Vol 11, Iss 22, p 3528 (2022)
The underlying mechanisms for statin-induced myopathy (SIM) are still equivocal. In this study, we employ Drosophila melanogaster to dissect possible underlying mechanisms for SIM. We observe that chronic fluvastatin treatment causes reduced general
Externí odkaz:
https://doaj.org/article/d87b7b6fdc5541df9494759d713adeac
Autor:
Hadi Boukhatmi
Publikováno v:
Cells, Vol 10, Iss 8, p 2112 (2021)
Muscle stem cells (MuSCs) are essential for muscle growth, maintenance and repair. Over the past decade, experiments in Drosophila have been instrumental in understanding the molecular and cellular mechanisms regulating MuSCs (also known as adult mus
Externí odkaz:
https://doaj.org/article/3393e91c50d04b0d81f66047487e9bee
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-19 (2017)
Abstract Background A stereotyped array of body wall muscles enables precision and stereotypy of animal movements. In Drosophila, each syncytial muscle forms via fusion of one founder cell (FC) with multiple fusion competent myoblasts (FCMs). The spe
Externí odkaz:
https://doaj.org/article/80bd34edc86a4653a02e45bd49a4c910
Autor:
Schiöth, Mohamed H. Al-Sabri, Neha Behare, Ahmed M. Alsehli, Samuel Berkins, Aadeya Arora, Eirini Antoniou, Eleni I. Moysiadou, Sowmya Anantha-Krishnan, Patricia D. Cosmen, Johanna Vikner, Thiago C. Moulin, Nourhene Ammar, Hadi Boukhatmi, Laura E. Clemensson, Mathias Rask-Andersen, Jessica Mwinyi, Michael J. Williams, Robert Fredriksson, Helgi B.
Publikováno v:
Cells; Volume 11; Issue 22; Pages: 3528
The underlying mechanisms for statin-induced myopathy (SIM) are still equivocal. In this study, we employ Drosophila melanogaster to dissect possible underlying mechanisms for SIM. We observe that chronic fluvastatin treatment causes reduced general
Autor:
Hadi Boukhatmi, Sarah Bray
Publikováno v:
eLife, Vol 7 (2018)
Adult stem cells are important for tissue maintenance and repair. One key question is how such cells are specified and then protected from differentiation for a prolonged period. Investigating the maintenance of Drosophila muscle progenitors (MPs) we
Externí odkaz:
https://doaj.org/article/021f5769e1cd46e7a3fdda78d1755513
Autor:
Domenica Lovero, Luca Giordano, René Massimiliano Marsano, Alvaro Sanchez-Martinez, Hadi Boukhatmi, Maik Drechsler, Marta Oliva, Alexander J Whitworth, Damiano Porcelli, Corrado Caggese
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201811 (2018)
Mitochondrial disorders associated with genetic defects of the ATP synthase are among the most deleterious diseases of the neuromuscular system that primarily manifest in newborns. Nevertheless, the number of established animal models for the elucida
Externí odkaz:
https://doaj.org/article/78dca27861864596b1b3c36e38056a8d
Autor:
Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy Hin Yan Tong, Simonetta Andreazza, Juliette J. Lee, Lyudmila Nedyalkova, Matej Ušaj, Alexander J. Whitworth, Brenda J. Andrews, Jason Moffat, Chad L. Myers, Kris Gevaert, Charles Boone, Rui Gonçalo Martinho, Thomas Arnesen
SUMMARYMost eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::472d7ebf86dfc87e0dd7981753ee3159
https://doi.org/10.1101/2022.09.01.505523
https://doi.org/10.1101/2022.09.01.505523