Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma.

Autor: Barone TA; Department of Neuro-oncology, Roswell Park Cancer Institute, Buffalo, New York, USA., Burkhart CA; Buffalo Biolabs, LLC, Buffalo, New York, USA., Safina A; Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, USA., Haderski G; Buffalo Biolabs, LLC, Buffalo, New York, USA., Gurova KV; Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, USA., Purmal AA; Incuron, LLC, Buffalo, New York, USA.; Cleveland Biolabs, Inc., Buffalo, New York, USA., Gudkov AV; Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, USA.; Cleveland Biolabs, Inc., Buffalo, New York, USA., Plunkett RJ; Department of Neuro-oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.

Publikováno v: Neuro-oncology [Neuro Oncol] 2017 Feb 01; Vol. 19 (2), pp. 186-196.

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.

Autor: Carter DR; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia. School of Women's and Children's Health, UNSW Australia, Randwick, New South Wales 2031, Australia., Murray J; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Cheung BB; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia. School of Women's and Children's Health, UNSW Australia, Randwick, New South Wales 2031, Australia., Gamble L; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Koach J; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Tsang J; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Sutton S; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Kalla H; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Syed S; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Gifford AJ; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia. Department of Anatomical Pathology (SEALS), Prince of Wales Hospital, Randwick, New South Wales 2031, Australia., Issaeva N; Department of Surgery, Otolaryngology, and Yale Cancer Center, Yale University, New Haven, CT 06511, USA., Biktasova A; Department of Surgery, Otolaryngology, and Yale Cancer Center, Yale University, New Haven, CT 06511, USA., Atmadibrata B; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Sun Y; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Sokolowski N; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Ling D; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Kim PY; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Webber H; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Clark A; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Ruhle M; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Liu B; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia., Oberthuer A; Department of Pediatric Oncology and Hematology, Children's Hospital, University of Cologne, 50931 Cologne, Germany. Department of Neonatology and Pediatric Intensive Care Medicine, Children's Hospital, University of Cologne, 50931 Cologne, Germany., Fischer M; Department of Pediatric Oncology and Hematology, Children's Hospital, University of Cologne, 50931 Cologne, Germany. Max Planck Institute for Metabolism Research, 50931 Cologne, Germany., Byrne J; Children's Cancer Research Unit, Kids Research Institute, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, New South Wales 2145, Australia. University of Sydney Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, New South Wales 2145, Australia., Saletta F; Children's Cancer Research Unit, Kids Research Institute, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, New South Wales 2145, Australia., Thwe le M; Children's Cancer Research Unit, Kids Research Institute, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, New South Wales 2145, Australia. University of Sydney Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, New South Wales 2145, Australia., Purmal A; Incuron, LLC, Buffalo, NY 14203, USA., Haderski G; Buffalo BioLabs, LLC, Buffalo, NY 14203, USA., Burkhart C; Buffalo BioLabs, LLC, Buffalo, NY 14203, USA., Speleman F; Center for Medical Genetics (CMGG), Ghent University, Medical Research Building (MRB1), De Pintelaan 185, 9000 Ghent, Belgium., De Preter K; Center for Medical Genetics (CMGG), Ghent University, Medical Research Building (MRB1), De Pintelaan 185, 9000 Ghent, Belgium., Beckers A; Center for Medical Genetics (CMGG), Ghent University, Medical Research Building (MRB1), De Pintelaan 185, 9000 Ghent, Belgium., Ziegler DS; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia. School of Women's and Children's Health, UNSW Australia, Randwick, New South Wales 2031, Australia. Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales 2031, Australia., Liu T; Center for Medical Genetics (CMGG), Ghent University, Medical Research Building (MRB1), De Pintelaan 185, 9000 Ghent, Belgium., Gurova KV; Incuron, LLC, Buffalo, NY 14203, USA. Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA., Gudkov AV; Incuron, LLC, Buffalo, NY 14203, USA. Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA., Norris MD; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia. University of New South Wales Centre for Childhood Cancer Research, Randwick, New South Wales 2031, Australia., Haber M; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia. g.marshall@unsw.edu.au mhaber@ccia.unsw.edu.au., Marshall GM; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia. Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales 2031, Australia. g.marshall@unsw.edu.au mhaber@ccia.unsw.edu.au.

Publikováno v: Science translational medicine [Sci Transl Med] 2015 Nov 04; Vol. 7 (312), pp. 312ra176.

Histone chaperone SSRP1 is required for apoptosis inhibition and mitochondrial function in HCC via transcriptional promotion of TRAP1.

Autor: Chen, Xuyang, Li, Mengxin, Wang, Ding, Wang, Qian, Wei, Xiaodong, Liu, Xiaorui, Yang, Jiaying, Kalvakolanu, Dhan V., Guo, Baofeng gbf@jlu.edu.cn, Zhang, Ling zhangling3@jlu.edu.cn

Publikováno v: Biochemistry & Cell Biology. 2023, Vol. 101 Issue 4, p361-376. 16p.

The FACT-targeted drug CBL0137 enhances the effects of rituximab to inhibit B-cell non-Hodgkin's lymphoma tumor growth by promoting apoptosis and autophagy.

Autor: Lv, Yan¹ (AUTHOR), Du, Yuxin¹ (AUTHOR) yuxindu0408@gmail.com, Li, Kening² (AUTHOR), Ma, Xiao³ (AUTHOR), Wang, Juan¹ (AUTHOR), Du, Tongde¹ (AUTHOR), Ma, Yuxin¹ (AUTHOR), Teng, Yue¹ (AUTHOR), Tang, Weiyan¹ (AUTHOR), Ma, Rong¹ (AUTHOR), Wu, Jianqiu¹ (AUTHOR), Wu, Jianzhong¹ (AUTHOR), Feng, Jifeng¹ (AUTHOR) jifengfeng2021@gmail.com

Publikováno v: Cell Communication & Signaling. 1/23/2023, Vol. 21 Issue 1, p1-17. 17p.

Therapeutic targeting the oncogenic driver EWSR1::FLI1 in Ewing sarcoma through inhibition of the FACT complex.

Autor: Mo J; Research Center of Translational medicine, Shanghai children's hospital, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.; Shanghai Key Laboratory of Reproductive Medicine, Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China., Tan K; Department of General Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, 200062, Shanghai, China., Dong Y; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China., Lu W; Shanghai Key Laboratory of Reproductive Medicine, Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China., Liu F; Research Center of Translational medicine, Shanghai children's hospital, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China., Mei Y; Research Center of Translational medicine, Shanghai children's hospital, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China., Huang H; Department of Hepatic Surgery and Liver Transplantation Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 200127, Shanghai, China., Zhao K; Research Center of Translational medicine, Shanghai children's hospital, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China., Lv Z; Department of General Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, 200062, Shanghai, China. zhibaolyu@163.com., Ye Y; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. youqiong.ye@shsmu.edu.cn., Tang Y; Research Center of Translational medicine, Shanghai children's hospital, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China. yujietang@shsmu.edu.cn.; Shanghai Key Laboratory of Reproductive Medicine, Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China. yujietang@shsmu.edu.cn.

Publikováno v: Oncogene [Oncogene] 2023 Jan; Vol. 42 (1), pp. 11-25. Date of Electronic Publication: 2022 Nov 10.