Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hadeel Khamis"'
Publikováno v:
Nucleic Acids Research
The interaction of transcription factors with their response elements in DNA is emerging as a highly complex process, whose characterization requires measuring the full distribution of binding and dissociation times in a well-controlled assay. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78652aa33a62a8ce88e0c765a45aa33d
https://doi.org/10.1093/nar/gkab843
https://doi.org/10.1093/nar/gkab843
Publikováno v:
Proceedings of the National Academy of Sciences. 116:12161-12166
The structure of promoter chromatin determines the ability of transcription factors (TFs) to bind to DNA and therefore has a profound effect on the expression levels of genes. However, the role of spontaneous nucleosome movements in this process is n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cafc901b1f588d615795f94daf8709
https://doi.org/10.1073/pnas.1815424116
https://doi.org/10.1073/pnas.1815424116
Publikováno v:
Molecular cell. 81(16)
Chromatosomes play a fundamental role in chromatin regulation, but a detailed understanding of their structure is lacking, partially due to their complex dynamics. Using single-molecule DNA unzipping with optical tweezers, we reveal that linker histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc63ba47616197b488a67863114415cf
https://pubmed.ncbi.nlm.nih.gov/34192510
https://pubmed.ncbi.nlm.nih.gov/34192510
Publikováno v:
Nucleic Acids Research
Retroviral reverse transcriptase catalyses the synthesis of an integration-competent dsDNA molecule, using as a substrate the viral RNA. Using optical tweezers, we follow the Murine Leukemia Virus reverse transcriptase as it performs strand-displacem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d125f0d7d3c4f623970dd797a9014b78
https://doi.org/10.1093/nar/gkx1168
https://doi.org/10.1093/nar/gkx1168
Publikováno v:
Nucleic Acids Research
Reverse transcriptase (RT) catalyzes the conversion of the viral RNA into an integration-competent double-stranded DNA, with a variety of enzymatic activities that include the ability to displace a non-template strand concomitantly with polymerizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7313ff13209ecd3440f1961abef7cc8d
http://europepmc.org/articles/PMC5737391
http://europepmc.org/articles/PMC5737391
Autor:
Sergei Rudnizky, Amit Meller, Philippa Melamed, Allison H. Squires, Omri Malik, Ariel Kaplan, Hadeel Khamis
Publikováno v:
Nucleic Acids Research
Most functional transcription factor (TF) binding sites deviate from their “consensus” recognition motif, although their sites and flanking sequences are often conserved across species. Here, we used single-molecule DNA unzipping with optical twe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd20a70a827f2f1a4fa7d1a9dc9596a
https://pubmed.ncbi.nlm.nih.gov/29253225
https://pubmed.ncbi.nlm.nih.gov/29253225
Nucleosomes, the basic building block of chromatin, regulate the accessibility of the transcription machinery to DNA. Recent studies have revealed that the nucleosome's spontaneous, thermally driven positional dynamics are modulated by different fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9766b90de2fb9afd1e44626b050759bb
Autor:
Sergei Rudnizky, Ariel Kaplan, Omri Malik, Melamed Philippa, Allison H. Squires, Amit Meller, Hadeel Khamis
Publikováno v:
Biophysical Journal. 114:683a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1812b7a9b74ec26923ed43dd5b77ab4d
https://doi.org/10.1016/j.bpj.2017.11.3686
https://doi.org/10.1016/j.bpj.2017.11.3686