Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Hacer, Karatas"'
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Hélène Adihou, Ranganath Gopalakrishnan, Tim Förster, Stéphanie M. Guéret, Raphael Gasper, Stefan Geschwindner, Carmen Carrillo García, Hacer Karatas, Ajaybabu V. Pobbati, Mercedes Vazquez‐Chantada, Paul Davey, Carola M. Wassvik, Jeremy Kah Sheng Pang, Boon Seng Soh, Wanjin Hong, Elisabetta Chiarparin, Dennis Schade, Alleyn T. Plowright, Eric Valeur, Malin Lemurell, Tom N. Grossmann, Herbert Waldmann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Targeting the interaction between transcription factor TEAD and its co-repressor VGL4 is an attractive strategy to chemically modulate Hippo signaling. Here, the authors develop a proteomimetic with stabilized tertiary structure that inhibits the TEA
Externí odkaz:
https://doaj.org/article/34105208594045348e3822ea97b488f7
Autor:
Guo, Yijing, Lei, Ienglam, Tian, Shuo, Gao, Wenbin, Hacer, Karatas **, Li, Yangbing **, Wang, Shaomeng **, Liu, Liu, Wang, Zhong
Publikováno v:
In Journal of Biological Chemistry 7 June 2019 294(23):9134-9146
Autor:
Süreyya Ölgen, Sevde Nur Biltekin Kaleli, Banu Taktak Karaca, Ural Ufuk Demirel, Hacer Karatas Bristow
Recent studies showed that the cooperation between c-SRC and EGFR is responsible for the more aggressive phenotype in diverse tumors, including glioblastomas and carcinomas of the colon, breast, and lung. Studies show that a combination of SRC and EG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r39c86a4b39b::685fd26b5aed5924b279b88ef6cc3d81
Autor:
Hacer Karatas, Essam Hamied Ahmed Hanashalshahaby, Unal Catal, Yasar Enes Butun, Elif Kurt, Sahin Gursel, Adil Kaya, Mustafa Guzel
Publikováno v:
Chemicke zvesti.
Favipiravir is a wide-spectrum antiviral generic drug that has received large attention during the recent COVID-19 pandemic. While there are synthetic strategies for favipiravir synthesis, economical procedures could contribute to industrial scale sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c23ad0a41891499a5cf28f4e80e7a2
https://pubmed.ncbi.nlm.nih.gov/36466109
https://pubmed.ncbi.nlm.nih.gov/36466109
TEAD-YAP Interaction Inhibitors and MDM2 Binders from DNA-Encoded Indole-Focused Ugi Peptidomimetics
Autor:
Marco Potowski, Alexander Dömling, Mateja Klika Škopić, Blaž Andlovic, Shabnam Shaabani, Roland Fried, Mohammad Akbarzadeh, Matthew Groves, Denise Dos Santos Smith, Hélène Adihou, Constantinos G. Neochoritis, Hacer Karatas, Andreas Brunschweiger, Tryfon Zarganes-Tzitzikas, Ran Zhang, Christian Ottmann, Verena B. K. Kunig, Stéphanie M. Guéret, Lukas Arendt, Jörg Rahnenführer, Ina Dormuth
Publikováno v:
Angewandte Chemie (International Ed. in English)
Angewandte Chemie-International Edition, 59(46), 20338-20342. Wiley
Angewandte Chemie (International ed. in English), 59(46), 20338-20342. WILEY-V C H VERLAG GMBH
Angewandte Chemie, 132(46), 20518-20522. Wiley-VCH Verlag
Angewandte Chemie International Edition
Angewandte Chemie-International Edition, 59(46), 20338-20342. Wiley
Angewandte Chemie (International ed. in English), 59(46), 20338-20342. WILEY-V C H VERLAG GMBH
Angewandte Chemie, 132(46), 20518-20522. Wiley-VCH Verlag
Angewandte Chemie International Edition
DNA-encoded combinatorial synthesis provides efficient and dense coverage of chemical space around privileged molecular structures. The indole side chain of tryptophan plays a prominent role in key, or ���hot spot���, regions of protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d406dc03f9c692763406bf3b95e514
https://research.rug.nl/en/publications/bad0555f-29a6-4aed-9e54-6c9780944773
https://research.rug.nl/en/publications/bad0555f-29a6-4aed-9e54-6c9780944773
Autor:
Stefan Geschwindner, Mercedes Vazquez-Chantada, Hacer Karatas, Carmen Carrillo García, Elisabetta Chiarparin, Dennis Schade, Malin Lemurell, Tom N. Grossmann, Paul R. J. Davey, Alleyn T. Plowright, Jeremy Kah Sheng Pang, Hélène Adihou, Boon Seng Soh, Stéphanie M. Guéret, Wanjin Hong, Carola M. Wassvik, Ranganath Gopalakrishnan, Eric Valeur, Tim Förster, Herbert Waldmann, Raphael Gasper, Ajaybabu V. Pobbati
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Adihou, H, Gopalakrishnan, R, Förster, T, Guéret, S M, Gasper, R, Geschwindner, S, Carrillo García, C, Karatas, H, Pobbati, A V, Vazquez-Chantada, M, Davey, P, Wassvik, C M, Pang, J K S, Soh, B S, Hong, W, Chiarparin, E, Schade, D, Plowright, A T, Valeur, E, Lemurell, M, Grossmann, T N & Waldmann, H 2020, ' A protein tertiary structure mimetic modulator of the Hippo signalling pathway ', Nature Communications, vol. 11, no. 1, 5425 . https://doi.org/10.1038/s41467-020-19224-8
Nature Communications, 11(1):5425. Nature Publishing Group
Nature Communications
Adihou, H, Gopalakrishnan, R, Förster, T, Guéret, S M, Gasper, R, Geschwindner, S, Carrillo García, C, Karatas, H, Pobbati, A V, Vazquez-Chantada, M, Davey, P, Wassvik, C M, Pang, J K S, Soh, B S, Hong, W, Chiarparin, E, Schade, D, Plowright, A T, Valeur, E, Lemurell, M, Grossmann, T N & Waldmann, H 2020, ' A protein tertiary structure mimetic modulator of the Hippo signalling pathway ', Nature Communications, vol. 11, no. 1, 5425 . https://doi.org/10.1038/s41467-020-19224-8
Nature Communications, 11(1):5425. Nature Publishing Group
Nature Communications
Transcription factors are key protein effectors in the regulation of gene transcription, and in many cases their activity is regulated via a complex network of protein–protein interactions (PPI). The chemical modulation of transcription factor acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a62c13a75607c3b0b4ec116b5e51b4
http://link.springer.com/article/10.1038/s41467-020-19224-8
http://link.springer.com/article/10.1038/s41467-020-19224-8
Autor:
Elizabeth Yihui Ng, Lara Dötsch, Wanjin Hong, Mohammad Akbarzadeh, Sasikala Thavam, Hélène Adihou, CongBao Kang, Sarah Zinken, Sonja Sievers, Axel Pahl, Ajaybabu V. Pobbati, Hacer Karatas, Christine Nowak, Gernot Hahne, Herbert Waldmann, Stéphanie M. Guéret, Malte Metz, Alexandra Friese
Publikováno v:
Journal of Medicinal Chemistry
Transcriptional enhanced associate domain (TEAD) transcription factors together with coactivators and corepressors modulate the expression of genes that regulate fundamental processes, such as organogenesis and cell growth, and elevated TEAD activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d188b53d24ea4b5125d0031211b3c2
https://doi.org/10.1021/acs.jmedchem.0c01275
https://doi.org/10.1021/acs.jmedchem.0c01275
Autor:
Mohammad Akbarzadeh, Jana Flegel, Sumersing Patil, Erchang Shang, Rishikesh Narayan, Marcel Buchholzer, Neda S. Kazemein Jasemi, Michael Grigalunas, Adrian Krzyzanowski, Daniel Abegg, Anton Shuster, Marco Potowski, Hacer Karatas, George Karageorgis, Niloufar Mosaddeghzadeh, Mia‐Lisa Zischinsky, Christian Merten, Christopher Golz, Lucas Brieger, Carsten Strohmann, Andrey P. Antonchick, Petra Janning, Alexander Adibekian, Roger S. Goody, Mohammad Reza Ahmadian, Slava Ziegler, Herbert Waldmann
Publikováno v:
Angewandte Chemie International Edition. 61
For the discovery of novel chemical matter generally endowed with bioactivity, strategies may be particularly efficient that combine previous insight about biological relevance, e.g., natural product (NP) structure, with methods that enable efficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18050fa1459aca99ac4d864826c82cd8
https://doi.org/10.1002/anie.202115193
https://doi.org/10.1002/anie.202115193
Autor:
Gernot Hahne, Sakshibeedu R. Bharath, Herbert Waldmann, Tom Mejuch, Stéphanie M. Guéret, Axel Pahl, Ernesto Guccione, Hacer Karatas, Haiwei Song, Ajaybabu V. Pobbati, Wanjin Hong, Sayan Chakraborty, Sonja Sievers, Pierre-Alexis Goy
Publikováno v:
ACS Chemical Biology. 14:2909-2921
The transcriptional co-regulators YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif) are the vertebrate downstream effectors of the Hippo signaling pathway that controls various physiological and pathological pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434aadaab449689f20748fc0260f63ce
https://doi.org/10.1021/acschembio.9b00786
https://doi.org/10.1021/acschembio.9b00786