Effect of N-acetyltransferase 2 genetic polymorphism on 4,4'-methylenebis(2-chloroaniline)-induced genotoxicity and oxidative stress.

Autor: Habil MR; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, 505 S. Hancock Street, CTR Rm 303, Louisville, KY, 40202, USA., Salazar-González RA; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, 505 S. Hancock Street, CTR Rm 303, Louisville, KY, 40202, USA., Doll MA; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, 505 S. Hancock Street, CTR Rm 303, Louisville, KY, 40202, USA., Hein DW; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, 505 S. Hancock Street, CTR Rm 303, Louisville, KY, 40202, USA. david.hein@louisville.edu.

Publikováno v: Archives of toxicology [Arch Toxicol] 2023 Jun; Vol. 97 (6), pp. 1773-1781. Date of Electronic Publication: 2023 May 04.

N-acetyltransferase 2 acetylator genotype-dependent N-acetylation and toxicity of the arylamine carcinogen β-naphthylamine in cryopreserved human hepatocytes.

Autor: Habil MR; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, 505 S. Hancock Street, CTR Rm 303, Louisville, KY, 40202, USA., Salazar-González RA; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, 505 S. Hancock Street, CTR Rm 303, Louisville, KY, 40202, USA., Doll MA; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, 505 S. Hancock Street, CTR Rm 303, Louisville, KY, 40202, USA., Hein DW; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, 505 S. Hancock Street, CTR Rm 303, Louisville, KY, 40202, USA. david.hein@louisville.edu.

Publikováno v: Archives of toxicology [Arch Toxicol] 2022 Dec; Vol. 96 (12), pp. 3257-3263. Date of Electronic Publication: 2022 Sep 16.

Acetyl coenzyme A kinetic studies on N -acetylation of environmental carcinogens by human N -acetyltransferase 1 and its NAT1*14B variant.

Autor: Habil MR; Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY, United States., Doll MA; Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY, United States., Hein DW; Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2022 Oct 28; Vol. 13, pp. 931323. Date of Electronic Publication: 2022 Oct 28 (Print Publication: 2022).

Expression of arylamine N-acetyltransferase 2 activity in immortalized human bronchial epithelial cells.

Autor: Wise JTF; Department of Pharmacology & Toxicology and Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40202, USA., Salazar-González RA; Department of Pharmacology & Toxicology and Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40202, USA., Habil MR; Department of Pharmacology & Toxicology and Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40202, USA., Doll MA; Department of Pharmacology & Toxicology and Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40202, USA., Hein DW; Department of Pharmacology & Toxicology and Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40202, USA. Electronic address: david.hein@louisville.edu.

Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2022 May 01; Vol. 442, pp. 115993. Date of Electronic Publication: 2022 Mar 27.

Identification and characterization of potent, selective, and efficacious inhibitors of human arylamine N-acetyltransferase 1.

Autor: Leggett CS; Department of Pharmacology and Toxicology, University of Louisville Health Science Center, University of Louisville, Kosair Charities Clinical and Translational Research Building Room 303, 505 South Hancock Street, Louisville, KY, 40202-1617, USA.; UofL Health Brown Cancer Center, University of Louisville, Louisville, KY, USA.; Executive Office of the President of the United States of AmericaOffice of Management and Budget, , Office of Information and Regulatory Affairs, Washington, DC, USA., Doll MA; Department of Pharmacology and Toxicology, University of Louisville Health Science Center, University of Louisville, Kosair Charities Clinical and Translational Research Building Room 303, 505 South Hancock Street, Louisville, KY, 40202-1617, USA.; UofL Health Brown Cancer Center, University of Louisville, Louisville, KY, USA., Salazar-González RA; Department of Pharmacology and Toxicology, University of Louisville Health Science Center, University of Louisville, Kosair Charities Clinical and Translational Research Building Room 303, 505 South Hancock Street, Louisville, KY, 40202-1617, USA.; UofL Health Brown Cancer Center, University of Louisville, Louisville, KY, USA., Habil MR; Department of Pharmacology and Toxicology, University of Louisville Health Science Center, University of Louisville, Kosair Charities Clinical and Translational Research Building Room 303, 505 South Hancock Street, Louisville, KY, 40202-1617, USA.; UofL Health Brown Cancer Center, University of Louisville, Louisville, KY, USA., Trent JO; UofL Health Brown Cancer Center, University of Louisville, Louisville, KY, USA.; Department of Medicine, University of Louisville, Louisville, KY, USA., Hein DW; Department of Pharmacology and Toxicology, University of Louisville Health Science Center, University of Louisville, Kosair Charities Clinical and Translational Research Building Room 303, 505 South Hancock Street, Louisville, KY, 40202-1617, USA. d.hein@louisville.edu.; UofL Health Brown Cancer Center, University of Louisville, Louisville, KY, USA. d.hein@louisville.edu.; Department of Medicine, University of Louisville, Louisville, KY, USA. d.hein@louisville.edu.

Publikováno v: Archives of toxicology [Arch Toxicol] 2022 Feb; Vol. 96 (2), pp. 511-524. Date of Electronic Publication: 2021 Nov 16.